• Gene id: 54981

Gene Summary

• Gene Symbol: NMRK1   Gene   UCSC   Ensembl
• Aliases: C9orf95, NRK1, bA235O14.2
• Gene name: nicotinamide riboside kinase 1
• Alternate names: nicotinamide riboside kinase 1, NRK 1, RNK 1, nicotinic acid riboside kinase 1, nmR-K 1, ribosylnicotinamide kinase 1, ribosylnicotinic acid kinase 1,
• Gene location: 9q21.13 (75088318: 75060576)     Exons: 13     NC_000009.12
• Gene summary(Entrez): Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the
• OMIM: 608704

Protein Summary

• Protein general information: Q9NWW6  
  • Name: Nicotinamide riboside kinase 1 (NRK 1) (NmR K 1) (EC 2.7.1.22) (Nicotinic acid riboside kinase 1) (EC 2.7.1.173) (Ribosylnicotinamide kinase 1) (RNK 1) (Ribosylnicotinic acid kinase 1)
  • Length: 199  
  • Mass: 23193
• Sequence:

  MKTFIIGISGVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESEIETDKNGFLQYDVLEALNMEKMMSAISCWME
  SARHSVVSTDQESAEEIPILIIEGFLLFNYKPLDTIWNRSYFLTIPYEECKRRRSTRVYQPPDSPGYFDGHVWPM
  YLKYRQEMQDITWEVVYLDGTKSEEDLFLQVYEDLIQELAKQKCLQVTA

• Structural information:
  • Interpro: IPR027417  
  • PDB: 2P0E 2QG6 2QL6 2QSY 2QSZ 2QT0 2QT1
  • PDBsum: 2P0E 2QG6 2QL6 2QSY 2QSZ 2QT0 2QT1
  • STRING: ENSP00000354387
• Other Databases: GeneCards:  NMRK1  Malacards:  NMRK1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016301	kinase activity	IBA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0019363	pyridine nucleotide biosynthetic process	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0050262	ribosylnicotinamide kinase activity	IEA	molecular function
GO:0050262	ribosylnicotinamide kinase activity	EXP	molecular function
GO:0050262	ribosylnicotinamide kinase activity	EXP	molecular function
GO:0061769	ribosylnicotinate kinase activity	EXP	molecular function
GO:0061769	ribosylnicotinate kinase activity	EXP	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0019674	NAD metabolic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0009435	NAD biosynthetic process	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00760	Nicotinate and nicotinamide metabolism

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)