• Gene id: 54969

Gene Summary

• Gene Symbol: HPF1   Gene   UCSC   Ensembl
• Aliases: C4orf27
• Gene name: histone PARylation factor 1
• Alternate names: histone PARylation factor 1, UPF0609 protein C4orf27,
• Gene location: 4q33 (169757943: 169729469)     Exons: 8     NC_000004.12
• OMIM: 602861

Protein Summary

• Protein general information: Q9NWY4  
  • Name: Histone PARylation factor 1
  • Length: 346  
  • Mass: 39436
• Sequence:

  MVGGGGKRRPGGEGPQCEKTTDVKKSKFCEADVSSDLRKEVENHYKLSLPEDFYHFWKFCEELDPEKPSDSLSAS
  LGLQLVGPYDILAGKHKTKKKSTGLNFNLHWRFYYDPPEFQTIIIGDNKTQYHMGYFRDSPDEFPVYVGINEAKK
  NCIIVPNGDNVFAAVKLFLTKKLREITDKKKINLLKNIDEKLTEAARELGYSLEQRTVKMKQRDKKVVTKTFHGA
  GLVVPVDKNDVGYRELPETDADLKRICKTIVEAASDEERLKAFAPIQEMMTFVQFANDECDYGMGLELGMDLFCY
  GSHYFHKVAGQLLPLAYNLLKRNLFAEIIEEHLANRSQENIDQLAA

• Structural information:
  • Interpro: IPR019361  
  • STRING: ENSP00000406598
• Other Databases: GeneCards:  HPF1  Malacards:  HPF1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042393	histone binding	IBA	molecular function
GO:0018312	peptidyl-serine ADP-ribosylation	IBA	biological process
GO:0008270	zinc ion binding	IBA	molecular function
GO:0072572	poly-ADP-D-ribose binding	IBA	molecular function
GO:0010835	regulation of protein ADP-ribosylation	IBA	biological process
GO:0006974	cellular response to DNA damage stimulus	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0042393	histone binding	IDA	molecular function
GO:0018312	peptidyl-serine ADP-ribosylation	IDA	biological process
GO:0018312	peptidyl-serine ADP-ribosylation	IMP	biological process
GO:0006974	cellular response to DNA damage stimulus	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0010835	regulation of protein ADP-ribosylation	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006974	cellular response to DNA damage stimulus	IMP	biological process
GO:0010835	regulation of protein ADP-ribosylation	IMP	biological process
GO:0005634	nucleus	IDA	cellular component
GO:0042393	histone binding	IBA	molecular function
GO:0018312	peptidyl-serine ADP-ribosylation	IBA	biological process
GO:0008270	zinc ion binding	IBA	molecular function
GO:0072572	poly-ADP-D-ribose binding	IBA	molecular function
GO:0010835	regulation of protein ADP-ribosylation	IBA	biological process
GO:0006974	cellular response to DNA damage stimulus	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0042393	histone binding	IDA	molecular function
GO:0018312	peptidyl-serine ADP-ribosylation	IDA	biological process
GO:0018312	peptidyl-serine ADP-ribosylation	IMP	biological process
GO:0006974	cellular response to DNA damage stimulus	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0010835	regulation of protein ADP-ribosylation	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006974	cellular response to DNA damage stimulus	IMP	biological process
GO:0010835	regulation of protein ADP-ribosylation	IMP	biological process
GO:0005634	nucleus	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881