• Gene id: 54878

Gene Summary

• Gene Symbol: DPP8   Gene   UCSC   Ensembl
• Aliases: DP8, DPRP-1, DPRP1, MST097, MSTP097, MSTP135, MSTP141
• Gene name: dipeptidyl peptidase 8
• Alternate names: dipeptidyl peptidase 8, DPP VIII, dipeptidyl peptidase IV-related protein 1, dipeptidyl peptidase VIII, prolyl dipeptidase DPP8,
• Gene location: 15q22.31 (65517712: 65442462)     Exons: 23     NC_000015.10
• Gene summary(Entrez): This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expr
• OMIM: 606819

Protein Summary

• Protein general information: Q6V1X1  
  • Name: Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase IV related protein 1) (DPRP 1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8)
  • Length: 898  
  • Mass: 103,358
• Sequence:

  MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYM
  MAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSR
  EEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADP
  DWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILR
  ILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGV
  EYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIH
  DIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRH
  GSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLY
  KLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQ
  LVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVG
  IHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRL
  LLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI

• Structural information:
  • Interpro: IPR029058  IPR001375  IPR002469  IPR038554  
  • PDB: 6EOO 6EOP 6EOS 6EOT
  • PDBsum: 6EOO 6EOP 6EOS 6EOT
  • STRING: ENSP00000339208
• Other Databases: GeneCards:  DPP8  Malacards:  DPP8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	NAS	cellular component
GO:0006508	proteolysis	NAS	biological process
GO:0006955	immune response	TAS	biological process
GO:0008236	serine-type peptidase activity	IEA	molecular function
GO:0008239	dipeptidyl-peptidase activity	NAS	molecular function
GO:0004177	aminopeptidase activity	IEA	molecular function
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	NAS	cellular component
GO:0006508	proteolysis	IEA	biological process
GO:0006508	proteolysis	IEA	biological process
GO:0006508	proteolysis	NAS	biological process
GO:0006955	immune response	TAS	biological process
GO:0008233	peptidase activity	IEA	molecular function
GO:0008236	serine-type peptidase activity	IEA	molecular function
GO:0008236	serine-type peptidase activity	IEA	molecular function
GO:0008239	dipeptidyl-peptidase activity	NAS	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	NAS	cellular component
GO:0006508	proteolysis	NAS	biological process
GO:0006955	immune response	TAS	biological process
GO:0008239	dipeptidyl-peptidase activity	NAS	molecular function

Diseases

Associated diseases	References
Male factor infertility	MIK: 16110352
Spermatogenesis defects	MIK: 16110352
Male fertility	MIK: 16110352
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
16110352	Spermatogenesis, male fertility				Male infertility
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)