• Gene id: 54826

Gene Summary

• Gene Symbol: GIN1   Gene   UCSC   Ensembl
• Aliases: GIN-1, TGIN1, ZH2C2
• Gene name: gypsy retrotransposon integrase 1
• Alternate names: gypsy retrotransposon integrase-like protein 1, Ty3/Gypsy integrase 1, zinc finger H2C2 domain-containing protein,
• Gene location: 5q21.1 (103120148: 103085999)     Exons: 9     NC_000005.10

Protein Summary

• Protein general information: Q9NXP7  
  • Name: Gypsy retrotransposon integrase like protein 1 (GIN 1) (Ty3/Gypsy integrase 1) (Zinc finger H2C2 domain containing protein)
  • Length: 522  
  • Mass: 59842
  • Tissue specificity: Widely expressed. Also found in tumors originating from parathyroid gland, colon, stomach, bladder, uterus and prostate. {ECO
• Sequence:

  MVRSGKNGDLHLKQIAYYKRTGEYHSTTLPSERSGIRRAAKKFVFKEKKLFYVGKDRKQNRLVIVSEEEKKKVLR
  ECHENDSGAHHGISRTLTLVESNYYWTSVTNDVKQWVYACQHCQVAKNTVIVAPKQHLLKVENPWSLVTVDLMGP
  FHTSNRSHVYAIIMTDLFTKWIVILPLCDVSASEVSKAIINIFFLYGPPQKIIMDQRDEFIQQINIELYRLFGIK
  QIVISHTSGTVNPTESTPNTIKAFLSKHCADHPNNWDDHLSAVSFAFNVTHLEPTKNTPYFQMFSRNPYMPETSD
  SLHEVDGDNTSMFAKILDAIKEADKIMENKTTSLGQMENNNLDELNKSKIIVKKKPKQLNPFHLKVGHEVLRQRK
  NWWKDGRFQSEWVGPCVIDYITESGCAVLRDNTGVRLKRPIKMSHLKPYIRESSEQESLYLLQGSVVADHDYIGL
  PEIPIGAYQANILVEDATIGIVDNELLTSSKDRELLEYRNTKISPLIDDHSSLEKQTFSLLDSSNQVLEYLS

• Structural information:
  • Protein Domains: (135..29-)
    (/note="Integrase-catalytic)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00457"-)
  • Interpro: IPR001584  IPR041588  IPR012337  IPR036397  
  • Prosite: PS50994
  • STRING: ENSP00000381970
• Other Databases: GeneCards:  GIN1  Malacards:  GIN1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0015074	DNA integration	IEA	biological process
GO:0003676	nucleic acid binding	IEA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)