• Gene id: 54814

Gene Summary

• Gene Symbol: QPCTL   Gene   UCSC   Ensembl
• Aliases: gQC
• Gene name: glutaminyl-peptide cyclotransferase like
• Alternate names: glutaminyl-peptide cyclotransferase-like protein, glutaminyl cyclase-like, golgi-resident glutaminyl-peptide cyclotransferase, isoQC,
• Gene location: 19q13.32 (45692399: 45703986)     Exons: 7     NC_000019.10

Protein Summary

• Protein general information: Q9NXS2  
  • Name: Glutaminyl peptide cyclotransferase like protein (EC 2.3.2.5) (Golgi resident glutaminyl peptide cyclotransferase) (isoQC) (gQC)
  • Length: 382  
  • Mass: 42924
• Sequence:

  MRSGGRGRPRLRLGERGLMEPLLPPKRRLLPRVRLLPLLLALAVGSAFYTIWSGWHRRTEELPLGRELRVPLIGS
  LPEARLRRVVGQLDPQRLWSTYLRPLLVVRTPGSPGNLQVRKFLEATLRSLTAGWHVELDPFTASTPLGPVDFGN
  VVATLDPRAARHLTLACHYDSKLFPPGSTPFVGATDSAVPCALLLELAQALDLELSRAKKQAAPVTLQLLFLDGE
  EALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIELFMLLDLLGAPNPTFYSHFPRTVRWFHRLRSIEKRLH
  RLNLLQSHPQEVMYFQPGEPFGSVEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLCRILAVF
  LAEYLGL

• Structural information:
  • Interpro: IPR037457  IPR007484  
  • CDD: cd03880
  • PDB: 3PB4 3PB6 3PB7 3PB8 3PB9
  • PDBsum: 3PB4 3PB6 3PB7 3PB8 3PB9
  • STRING: ENSP00000012049
• Other Databases: GeneCards:  QPCTL  Malacards:  QPCTL

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008270	zinc ion binding	IBA	molecular function
GO:0016603	glutaminyl-peptide cyclotransferase activity	IBA	molecular function
GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase	IBA	biological process
GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase	IDA	biological process
GO:0016603	glutaminyl-peptide cyclotransferase activity	IDA	molecular function
GO:0008270	zinc ion binding	IDA	molecular function
GO:0016603	glutaminyl-peptide cyclotransferase activity	IEA	molecular function
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016746	transferase activity, transferring acyl groups	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016603	glutaminyl-peptide cyclotransferase activity	IEA	molecular function
GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase	IDA	biological process
GO:0016603	glutaminyl-peptide cyclotransferase activity	IDA	molecular function
GO:0005794	Golgi apparatus	IDA	cellular component
GO:0000139	Golgi membrane	IEA	cellular component
GO:0005794	Golgi apparatus	IDA	cellular component
GO:0016020	membrane	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881