|
Gene id |
54763 |
| Gene Summary Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
ROPN1 Gene UCSC Ensembl |
|
Aliases |
CT91, ODF6, RHPNAP1, ROPN1A, ropporin |
|
Gene name |
rhophilin associated tail protein 1 |
|
Alternate names |
ropporin-1A, cancer/testis antigen 91, outer dense fiber of sperm tails 6, rhophilin-associated protein 1A, ropporin, rhophilin associated protein 1, testis secretory sperm-binding protein Li 239w, |
|
Gene location |
3q21.1 (123992169: 123968520) Exons: 8 NC_000016.10
|
|
Gene summary(Entrez) |
The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosp
|
|
OMIM |
611757 |
|
| Associated diseases |
References |
| Apoplexy | GAD: 20107840 |
| Causes defects in murine sperm motility | MIK: 23303679 |
| Male factor infertility | MIK: 25704993 |
| Asthenozoospermia | MIK: 29247344 |
| Asthenozoospermia | MIK: 25704993 |
| Asthenozoospermia | MIK: 25704993 |
| Male infertility | MIK: 29247344 |
| Causes defects in murine sperm motility | MIK: 23303679 |
| Hypospermatogenesis | MIK: 28361989 |
| Non obstructive azoospermia | MIK: 24012201 |
| Spermatogenic defects | MIK: 31037746 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 29247344 |
Asthenozoo
spermia, M
ale infert
ility
|
|
Caucasi
an
|
120 (60 normozo
ospermic and 60
asthenozoosper
mic)
|
Male infertility |
ROPN1
CABYR
|
Show abstract |
| 25704993 |
Asthenozoo
spermia, M
ale infert
ility
|
|
|
24 infertile as
thenozoospermia
men
|
Male infertility |
|
Show abstract |
| 23303679 |
Causes def
ects in mu
rine sperm
motility
|
|
|
|
Male infertility |
|
Show abstract |
| 24012201 |
Non obstru
ctive azoo
spermia
|
|
|
31 (4 controls,
27 cases)
|
Male infertility |
GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 28361989 |
Hyposperma
togenesis
|
|
|
6 (3 controls,
3 Klienfelter s
yndrome
|
Male infertility |
Microarray
|
Show abstract |
| 31037746 |
Spermatoge
nic defect
s
|
|
|
16 (1 control,
15 cases)
|
Male infertility |
GSE6023 analyzed using GEO2R
|
Show abstract |
|