• Gene id: 54734

Gene Summary

• Gene Symbol: RAB39A   Gene   UCSC   Ensembl
• Aliases: RAB39
• Gene name: RAB39A, member RAS oncogene family
• Alternate names: ras-related protein Rab-39A, RAB39, member RAS oncogene family, rab-39, rab-related GTP-binding protein,
• Gene location: 11q22.3 (107928447: 107963481)     Exons: 8     NC_000011.10

Protein Summary

• Protein general information: Q14964  
  • Name: Ras related protein Rab 39A (Rab 39)
  • Length: 217  
  • Mass: 25007
• Sequence:

  METIWIYQFRLIVIGDSTVGKSCLLHRFTQGRFPGLRSPACDPTVGVDFFSRLLEIEPGKRIKLQLWDTAGQERF
  RSITRSYYRNSVGGFLVFDITNRRSFEHVKDWLEEAKMYVQPFRIVFLLVGHKCDLASQRQVTREEAEKLSADCG
  MKYIETSAKDATNVEESFTILTRDIYELIKKGEICIQDGWEGVKSGFVPNTVHSSEEAVKPRKECFC

• Structural information:
  • Interpro: IPR027417  IPR041818  IPR005225  IPR001806  
  • Prosite: PS51419
  • CDD: cd04111
  • DIP: 60521
  • STRING: ENSP00000322594
• Other Databases: GeneCards:  RAB39A  Malacards:  RAB39A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006886	intracellular protein transport	IBA	biological process
GO:0003924	GTPase activity	IBA	molecular function
GO:0012505	endomembrane system	IBA	cellular component
GO:0032482	Rab protein signal transduction	IBA	biological process
GO:0045335	phagocytic vesicle	IDA	cellular component
GO:0090385	phagosome-lysosome fusion	IMP	biological process
GO:0090383	phagosome acidification	IMP	biological process
GO:0003924	GTPase activity	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0032482	Rab protein signal transduction	IEA	biological process
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0005764	lysosome	IEA	cellular component
GO:0005525	GTP binding	IEA	molecular function
GO:0015031	protein transport	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0006914	autophagy	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005764	lysosome	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0030670	phagocytic vesicle membrane	IEA	cellular component
GO:0045335	phagocytic vesicle	IEA	cellular component
GO:0005525	GTP binding	NAS	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881