|
Gene id |
5469 |
| Gene Summary KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
MED1 Gene UCSC Ensembl |
|
Aliases |
CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2 |
|
Gene name |
mediator complex subunit 1 |
|
Alternate names |
mediator of RNA polymerase II transcription subunit 1, ARC205, PPAR-binding protein, PPARG binding protein, TR-interacting protein 2, TRIP-2, activator-recruited cofactor 205 kDa component, p53 regulatory protein RB18A, peroxisome proliferator-activated receptor-, |
|
Gene location |
17q12 (39451280: 39404284) Exons: 17 NC_000013.11
|
|
Gene summary(Entrez) |
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. T
|
|
OMIM |
604311 |
|
| Pathway id | Pathway name |
|---|
| hsa04919 | Thyroid hormone signaling pathway | | hsa01522 | Endocrine resistance | | hsa04919 | Thyroid hormone signaling pathway | | hsa01522 | Endocrine resistance | |
|
| Associated diseases |
References |
| Cancer (breast) | GAD: 17117180 |
| Cancer (breast) | GAD: 17117180 |
| Cancer (prostate) | GAD: 19255064 |
| Gestational diabetes mellitus | GAD: 15095040 |
| Diabetes | GAD: 15095040 |
| Spermatogenesis defects | MIK: 25778538 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Cryptorchidism | MIK: 28606200 |
| Regulates meiotic progression during spermatogenesis | MIK: 25778538 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 25778538 |
Regulates
meiotic pr
ogression
during spe
rmatogenes
is
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
| 28606200 |
Cryptorchi
dism
|
|
|
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
|