• Gene id: 54629

Gene Summary

• Gene Symbol: MINDY2   Gene   UCSC   Ensembl
• Aliases: FAM63B
• Gene name: MINDY lysine 48 deubiquitinase 2
• Alternate names: ubiquitin carboxyl-terminal hydrolase MINDY-2, MINDY deubiquitinase 2, deubiquitinating enzyme MINDY-2, family with sequence similarity 63 member B, protein FAM63B,
• Gene location: 15q21.3-q22.1 (58771257: 58861899)     Exons: 10     NC_000015.10
• OMIM: 618408

Protein Summary

• Protein general information: Q8NBR6  
  • Name: Ubiquitin carboxyl terminal hydrolase MINDY 2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY 2) (Protein FAM63B)
  • Length: 621  
  • Mass: 67106
• Sequence:

  MESSPESLQPLEHGVAAGPASGTGSSQEGLQETRLAAGDGPGVWAAETSGGNGLGAAAARRSLPDSASPAGSPEV
  PGPCSSSAGLDLKDSGLESPAAAEAPLRGQYKVTASPETAVAGVGHELGTAGDAGARPDLAGTCQAELTAAGSEE
  PSSAGGLSSSCSDPSPPGESPSLDSLESFSNLHSFPSSCEFNSEEGAENRVPEEEEGAAVLPGAVPLCKEEEGEE
  TAQVLAASKERFPGQSVYHIKWIQWKEENTPIITQNENGPCPLLAILNVLLLAWKVKLPPMMEIITAEQLMEYLG
  DYMLDAKPKEISEIQRLNYEQNMSDAMAILHKLQTGLDVNVRFTGVRVFEYTPECIVFDLLDIPLYHGWLVDPQI
  DDIVKAVGNCSYNQLVEKIISCKQSDNSELVSEGFVAEQFLNNTATQLTYHGLCELTSTVQEGELCVFFRNNHFS
  TMTKYKGQLYLLVTDQGFLTEEKVVWESLHNVDGDGNFCDSEFHLRPPSDPETVYKGQQDQIDQDYLMALSLQQE
  QQSQEINWEQIPEGISDLELAKKLQEEEDRRASQYYQEQEQAAAAAAAASTQAQQGQPAQASPSSGRQSGNSERK
  RKEPREKDKEKEKEKNSCVIL

• Structural information:
  • Interpro: IPR007518  IPR033979  
  • STRING: ENSP00000452885
• Other Databases: GeneCards:  MINDY2  Malacards:  MINDY2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0071944	cell periphery	IBA	cellular component
GO:0016807	cysteine-type carboxypeptidase activity	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:1990380	Lys48-specific deubiquitinase activity	IBA	molecular function
GO:0071108	protein K48-linked deubiquitination	IBA	biological process
GO:0071795	K11-linked polyubiquitin modification-dependent protein binding	IDA	molecular function
GO:0071796	K6-linked polyubiquitin modification-dependent protein binding	IDA	molecular function
GO:0016807	cysteine-type carboxypeptidase activity	IDA	molecular function
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	IDA	molecular function
GO:0036435	K48-linked polyubiquitin modification-dependent protein binding	IDA	molecular function
GO:1990380	Lys48-specific deubiquitinase activity	IDA	molecular function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	IEA	molecular function
GO:1990380	Lys48-specific deubiquitinase activity	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008234	cysteine-type peptidase activity	IEA	molecular function
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IEA	molecular function
GO:0005654	nucleoplasm	IDA	cellular component
GO:0008150	biological_process	ND	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq