• Gene id: 54625

Gene Summary

• Gene Symbol: PARP14   Gene   UCSC   Ensembl
• Aliases: ARTD8, BAL2, PARP-14, pART8
• Gene name: poly(ADP-ribose) polymerase family member 14
• Alternate names: protein mono-ADP-ribosyltransferase PARP14, ADP-ribosyltransferase diphtheria toxin-like 8, B-aggressive lymphoma 2, b aggressive lymphoma protein 2, collaborator of STAT6, poly [ADP-ribose] polymerase 14,
• Gene location: 3q21.1 (21043408: 20999595)     Exons: 14     NC_000017.11
• Gene summary(Entrez): This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety
• OMIM: 610028

Protein Summary

• Protein general information: Q460N5  
  • Name: Protein mono ADP ribosyltransferase PARP14 (EC 2.4.2. ) (ADP ribosyltransferase diphtheria toxin like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP ribose] polymerase 14) (PARP 14)
  • Length: 1801  
  • Mass: 202800
  • Tissue specificity: Expressed in macrophages. {ECO
• Sequence:

  MAVPGSFPLLVEGSWGPDPPKNLNTKLQMYFQSPKRSGGGECEVRQDPRSPSRFLVFFYPEDVRQKVLERKNHEL
  VWQGKGTFKLTVQLPATPDEIDHVFEEELLTKESKTKEDVKEPDVSEELDTKLPLDGGLDKMEDIPEECENISSL
  VAFENLKANVTDIMLILLVENISGLSNDDFQVEIIRDFDVAVVTFQKHIDTIRFVDDCTKHHSIKQLQLSPRLLE
  VTNTIRVENLPPGADDYSLKLFFENPYNGGGRVANVEYFPEESSALIEFFDRKVLDTIMATKLDFNKMPLSVFPY
  YASLGTALYGKEKPLIKLPAPFEESLDLPLWKFLQKKNHLIEEINDEMRRCHCELTWSQLSGKVTIRPAATLVNE
  GRPRIKTWQADTSTTLSSIRSKYKVNPIKVDPTMWDTIKNDVKDDRILIEFDTLKEMVILAGKSEDVQSIEVQVR
  ELIESTTQKIKREEQSLKEKMIISPGRYFLLCHSSLLDHLLTECPEIEICYDRVTQHLCLKGPSADVYKAKCEIQ
  EKVYTMAQKNIQVSPEIFQFLQQVNWKEFSKCLFIAQKILALYELEGTTVLLTSCSSEALLEAEKQMLSALNYKR
  IEVENKEVLHGKKWKGLTHNLLKKQNSSPNTVIINELTSETTAEVIITGCVKEVNETYKLLFNFVEQNMKIERLV
  EVKPSLVIDYLKTEKKLFWPKIKKVNVQVSFNPENKQKGILLTGSKTEVLKAVDIVKQVWDSVCVKSVHTDKPGA
  KQFFQDKARFYQSEIKRLFGCYIELQENEVMKEGGSPAGQKCFSRTVLAPGVVLIVQQGDLARLPVDVVVNASNE
  DLKHYGGLAAALSKAAGPELQADCDQIVKREGRLLPGNATISKAGKLPYHHVIHAVGPRWSGYEAPRCVYLLRRA
  VQLSLCLAEKYKYRSIAIPAISSGVFGFPLGRCVETIVSAIKENFQFKKDGHCLKEIYLVDVSEKTVEAFAEAVK
  TVFKATLPDTAAPPGLPPAAAGPGKTSWEKGSLVSPGGLQMLLVKEGVQNAKTDVVVNSVPLDLVLSRGPLSKSL
  LEKAGPELQEELDTVGQGVAVSMGTVLKTSSWNLDCRYVLHVVAPEWRNGSTSSLKIMEDIIRECMEITESLSLK
  SIAFPAIGTGNLGFPKNIFAELIISEVFKFSSKNQLKTLQEVHFLLHPSDHENIQAFSDEFARRANGNLVSDKIP
  KAKDTQGFYGTVSSPDSGVYEMKIGSIIFQVASGDITKEEADVIVNSTSNSFNLKAGVSKAILECAGQNVERECS
  QQAQQRKNDYIITGGGFLRCKNIIHVIGGNDVKSSVSSVLQECEKKNYSSICLPAIGTGNAKQHPDKVAEAIIDA
  IEDFVQKGSAQSVKKVKVVIFLPQVLDVFYANMKKREGTQLSSQQSVMSKLASFLGFSKQSPQKKNHLVLEKKTE
  SATFRVCGENVTCVEYAISWLQDLIEKEQCPYTSEDECIKDFDEKEYQELNELQKKLNINISLDHKRPLIKVLGI
  SRDVMQARDEIEAMIKRVRLAKEQESRADCISEFIEWQYNDNNTSHCFNKMTNLKLEDARREKKKTVDVKINHRH
  YTVNLNTYTATDTKGHSLSVQRLTKSKVDIPAHWSDMKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIER
  IQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTYFAVNANYSAND
  TYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFR
  K

• Structural information:
  • Protein Domains: (791..97-)
    (/note="Macro-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00490-)
    (1003..119-)
    (/note="Macro-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00490-)
    (1216..138-)
    (/note="Macro-3)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU0-)
  • Interpro: IPR002589  IPR012677  IPR034517  IPR012317  IPR004170   IPR037197  
  • Prosite: PS51154 PS51059 PS50918
  • CDD: cd12543
  • PDB: 3GOY 3Q6Z 3Q71 3SE2 3SMI 3SMJ 3VFQ 4ABK 4ABL 4D86 4F1L 4F1Q 4PY4 5LXP 5LYH 5NQE 5O2D 5QHT 5QHU 5QHV 5QHW 5QHX 5QHY 5QHZ 5QI0 5QI1 5QI2 5QI3 5QI4 5QI5 5QI6 5QI7 5QI8 5QI9 5QIA 5V7T 5V7W 6FYM 6FZM 6G0W
  • PDBsum: 3GOY 3Q6Z 3Q71 3SE2 3SMI 3SMJ 3VFQ 4ABK 4ABL 4D86 4F1L 4F1Q 4PY4 5LXP 5LYH 5NQE 5O2D 5QHT 5QHU 5QHV 5QHW 5QHX 5QHY 5QHZ 5QI0 5QI1 5QI2 5QI3 5QI4 5QI5 5QI6 5QI7 5QI8 5QI9 5QIA 5V7T 5V7W 6FYM 6FZM 6G0W
  • DIP: 61130
  • STRING: ENSP00000418194
• Other Databases: GeneCards:  PARP14  Malacards:  PARP14

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0070212	protein poly-ADP-ribosylation	IBA	biological process
GO:0010629	negative regulation of gene expression	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0003950	NAD+ ADP-ribosyltransferase activity	IBA	molecular function
GO:0003714	transcription corepressor activity	IBA	molecular function
GO:1990404	protein ADP-ribosylase activity	IBA	molecular function
GO:0140289	protein mono-ADP-ribosylation	IBA	biological process
GO:0140289	protein mono-ADP-ribosylation	IDA	biological process
GO:1990404	protein ADP-ribosylase activity	IDA	molecular function
GO:0140289	protein mono-ADP-ribosylation	IDA	biological process
GO:1990404	protein ADP-ribosylase activity	IDA	molecular function
GO:0003950	NAD+ ADP-ribosyltransferase activity	IEA	molecular function
GO:0045087	innate immune response	IEA	biological process
GO:0002376	immune system process	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0016757	transferase activity, transferring glycosyl groups	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0060336	negative regulation of interferon-gamma-mediated signaling pathway	IEA	biological process
GO:1902216	positive regulation of interleukin-4-mediated signaling pathway	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:1903507	negative regulation of nucleic acid-templated transcription	IEA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0003950	NAD+ ADP-ribosyltransferase activity	IDA	molecular function
GO:0006471	protein ADP-ribosylation	IDA	biological process
GO:0016020	membrane	HDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IMP	biological process
GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	IMP	biological process
GO:0019899	enzyme binding	IPI	molecular function
GO:1902216	positive regulation of interleukin-4-mediated signaling pathway	IMP	biological process
GO:0010629	negative regulation of gene expression	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0060336	negative regulation of interferon-gamma-mediated signaling pathway	IMP	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq