• Gene id: 54558

Gene Summary

• Gene Symbol: SPATA6   Gene   UCSC   Ensembl
• Aliases: HASH, SRF-1, SRF1
• Gene name: spermatogenesis associated 6
• Alternate names: spermatogenesis-associated protein 6, spermatogenesis-related factor-1, testicular tissue protein Li 178,
• Gene location: 1p33 (48472207: 48258642)     Exons: 21     NC_000001.11
• OMIM: 613947

Protein Summary

• Protein general information: Q9NWH7  
  • Name: Spermatogenesis associated protein 6
  • Length: 488  
  • Mass: 55989
• Sequence:

  MPKVKALQCALALEISSVTCPGVVLKDKEDIYLSICVFGQYKKTQCVPATFPLVFNARMVFEKVFPDAVDPGDVV
  TQLEYDTAVFELIQLVPPVGETLSTYDENTRDFMFPGPNQMSGHHDSNRQVTMRRISGLRGNAPRLEFSTTSVIT
  ECLISSRKCHTQDKFIYHLAPVEKSHGRLQNRTSRSQKKKSKSPERSKYCINAKNYEQPTISSKSHSPSPYTKRR
  MCELSEDTRRRLAHLNLGPYEFKKETDKPPFVIRHVDPPSPRADTLLGSSGRDCERDGWSRVHNDHSHLGCCRPK
  DYKVIRTPHGRDFDDSLEKCEEYLSPRSCSKPRHSARTLLVHSAPSTMPKHSPSPVLNRASLRERFHSDWCSPSN
  CDEIHDRVKNVLKSHQAHQRHLYDERDLEKDDELELKRSLLCRDSAYDSDPEYSSCQQPRGTFHLDDGEYWSNRA
  ASYKGKSHRPIFENSMDKMYRNLYKKACSSASHTQESF

• Structural information:
  • Interpro: IPR027207  IPR042769  IPR032732  
  • STRING: ENSP00000360913
• Other Databases: GeneCards:  SPATA6  Malacards:  SPATA6

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007283	spermatogenesis	IBA	biological process
GO:0032027	myosin light chain binding	IBA	molecular function
GO:0044458	motile cilium assembly	IBA	biological process
GO:0097224	sperm connecting piece	IBA	cellular component
GO:0007283	spermatogenesis	ISS	biological process
GO:0097224	sperm connecting piece	ISS	cellular component
GO:0044458	motile cilium assembly	ISS	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0032027	myosin light chain binding	IEA	molecular function
GO:0097224	sperm connecting piece	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0030154	cell differentiation	IEA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0031514	motile cilium	IEA	cellular component
GO:0007275	multicellular organism development	IEA	biological process
GO:0005929	cilium	IEA	cellular component
GO:0007283	spermatogenesis	IEA	biological process
GO:0097224	sperm connecting piece	IEA	cellular component
GO:0044458	motile cilium assembly	IEA	biological process
GO:0032027	myosin light chain binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0031514	motile cilium	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq