• Gene id: 54529

Gene Summary

• Gene Symbol: ASNSD1   Gene   UCSC   Ensembl
• Aliases: NBLA00058, NS3TP1
• Gene name: asparagine synthetase domain containing 1
• Alternate names: asparagine synthetase domain-containing protein 1, HCV NS3-transactivated protein 1,
• Gene location: 2q32.2 (52706082: 52694483)     Exons: 12     NC_000003.12

Protein Summary

• Protein general information: Q9NWL6  
  • Name: Asparagine synthetase domain containing protein 1 (HCV NS3 transactivated protein 1)
  • Length: 643  
  • Mass: 72080
• Sequence:

  MCGICCSVNFSAEHFSQDLKEDLLYNLKQRGPNSSKQLLKSDVNYQCLFSAHVLHLRGVLTTQPVEDERGNVFLW
  NGEIFSGIKVEAEENDTQILFNYLSSCKNESEILSLFSEVQGPWSFIYYQASSHYLWFGRDFFGRRSLLWHFSNL
  GKSFCLSSVGTQTSGLANQWQEVPASGLFRIDLKSTVISGCIILQLYPWKYISRENIIEENVNSLSQISADLPAF
  VSVVANEAKLYLEKPVVPLNMMLPQAALETHCSNISNVPPTREILQVFLTDVHMKEVIQQFIDVLSVAVKKRVLC
  LPRDENLTANEVLKTCDRKANVAILFSGGIDSMVIATLADRHIPLDEPIDLLNVAFIAEEKTMPTTFNREGNKQK
  NKCEIPSEEFSKDVAAAAADSPNKHVSVPDRITGRAGLKELQAVSPSRIWNFVEINVSMEELQKLRRTRICHLIR
  PLDTVLDDSIGCAVWFASRGIGWLVAQEGVKSYQSNAKVVLTGIGADEQLAGYSRHRVRFQSHGLEGLNKEIMME
  LGRISSRNLGRDDRVIGDHGKEARFPFLDENVVSFLNSLPIWEKANLTLPRGIGEKLLLRLAAVELGLTASALLP
  KRAMQFGSRIAKMEKINEKASDKCGRLQIMSLENLSIEKETKL

• Structural information:
  • Protein Domains: (2..18-)
    type-2 (/note="Glutamine-amidotransferase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00609-)
    (285..60-)
    (/note="Asparagine-synthetase")
  • Interpro: IPR001962  IPR017932  IPR029055  
  • Prosite: PS51278
  • CDD: cd01991
  • STRING: ENSP00000260952
• Other Databases: GeneCards:  ASNSD1  Malacards:  ASNSD1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006529	asparagine biosynthetic process	IEA	biological process
GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	IEA	molecular function
GO:0006529	asparagine biosynthetic process	IEA	biological process
GO:0008652	cellular amino acid biosynthetic process	IEA	biological process
GO:0006541	glutamine metabolic process	IEA	biological process
GO:0003674	molecular_function	ND	molecular function
GO:0005575	cellular_component	ND	cellular component
GO:0008150	biological_process	ND	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881