• Gene id: 54504

Gene Summary

• Gene Symbol: CPVL   Gene   UCSC   Ensembl
• Aliases: HVLP
• Gene name: carboxypeptidase vitellogenic like
• Alternate names: probable serine carboxypeptidase CPVL, CP-Mac carboxypeptidase, VCP-like protein, carboxypeptidase WUG, vitellogenic carboxypeptidase-like protein,
• Gene location: 7p14.3 (50611773: 50606453)     Exons: 4     NC_000003.12
• Gene summary(Entrez): The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptid
• OMIM: 609780

Protein Summary

• Protein general information: Q9H3G5  
  • Name: Probable serine carboxypeptidase CPVL (EC 3.4.16. ) (Carboxypeptidase, vitellogenic like) (Vitellogenic carboxypeptidase like protein) (VCP like protein) (hVLP)
  • Length: 476  
  • Mass: 54164
  • Tissue specificity: Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta.
• Sequence:

  MVGAMWKVIVSLVLLMPGPCDGLFRSLYRSVSMPPKGDSGQPLFLTPYIEAGKIQKGRELSLVGPFPGLNMKSYA
  GFLTVNKTYNSNLFFWFFPAQIQPEDAPVVLWLQGGPGGSSMFGLFVEHGPYVVTSNMTLRDRDFPWTTTLSMLY
  IDNPVGTGFSFTDDTHGYAVNEDDVARDLYSALIQFFQIFPEYKNNDFYVTGESYAGKYVPAIAHLIHSLNPVRE
  VKINLNGIAIGDGYSDPESIIGGYAEFLYQIGLLDEKQKKYFQKQCHECIEHIRKQNWFEAFEILDKLLDGDLTS
  DPSYFQNVTGCSNYYNFLRCTEPEDQLYYVKFLSLPEVRQAIHVGNQTFNDGTIVEKYLREDTVQSVKPWLTEIM
  NNYKVLIYNGQLDIIVAAALTERSLMGMDWKGSQEYKKAEKKVWKIFKSDSEVAGYIRQAGDFHQVIIRGGGHIL
  PYDQPLRAFDMINRFIYGKGWDPYVG

• Structural information:
  • Interpro: IPR029058  IPR001563  IPR018202  
  • Prosite: PS00131
  • STRING: ENSP00000387164
• Other Databases: GeneCards:  CPVL  Malacards:  CPVL

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004185	serine-type carboxypeptidase activity	IBA	molecular function
GO:0051603	proteolysis involved in cellular protein catabolic process	IBA	biological process
GO:0004185	serine-type carboxypeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0006508	proteolysis	IEA	biological process
GO:0004180	carboxypeptidase activity	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881