• Gene id: 54503

Gene Summary

• Gene Symbol: ZDHHC13   Gene   UCSC   Ensembl
• Aliases: HIP14L, HIP3RP
• Gene name: zinc finger DHHC-type palmitoyltransferase 13
• Alternate names: palmitoyltransferase ZDHHC13, DHHC-13, HIP14-related protein, huntingtin interacting protein HIP3RP, huntingtin-interacting protein 14-related protein, probable palmitoyltransferase ZDHHC13, putative MAPK-activating protein PM03, putative NF-kappa-B-activating p,
• Gene location: 11p15.1 (19117098: 19176419)     Exons: 20     NC_000011.10
• OMIM: 612815

Protein Summary

• Protein general information: Q8IUH4  
  • Name: Palmitoyltransferase ZDHHC13 (EC 2.3.1.225) (Huntingtin interacting protein 14 related protein) (HIP14 related protein) (Huntingtin interacting protein HIP3RP) (Putative MAPK activating protein PM03) (Putative NF kappa B activating protein 209) (Zinc fing
  • Length: 622  
  • Mass: 70861
• Sequence:

  MEGPGLGSQCRNHSHGPHPPGFGRYGICAHENKELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDV
  RQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGF
  SSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAV
  AAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLWRWLQKCELFLLLMLSV
  ITMWAIGYILDFNSDSWLLKGCLLVTLFFLTSLFPRFLVGYKNLVYLPTAFLLSSVFWIFMTWFILFFPDLAGAP
  FYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNCCVA
  RYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSFIYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILM
  LATFHFSWSTFLLLNQLFQIAFLGLTSHERISLQKQSKHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCV
  VDWTSQYTMVFHPAREKVLRSV

• Structural information:
  • Protein Domains: (426..47-)
    (/note="DHHC-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00067"-)
  • Interpro: IPR002110  IPR020683  IPR036770  IPR001594  IPR030290  
  • Prosite: PS50297 PS50088 PS50216
  • STRING: ENSP00000400113
• Other Databases: GeneCards:  ZDHHC13  Malacards:  ZDHHC13

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016409	palmitoyltransferase activity	IBA	molecular function
GO:0018345	protein palmitoylation	IBA	biological process
GO:0000139	Golgi membrane	IBA	cellular component
GO:0030660	Golgi-associated vesicle membrane	ISS	cellular component
GO:0000139	Golgi membrane	ISS	cellular component
GO:0016409	palmitoyltransferase activity	ISS	molecular function
GO:0015095	magnesium ion transmembrane transporter activity	ISS	molecular function
GO:0015095	magnesium ion transmembrane transporter activity	IEA	molecular function
GO:0016409	palmitoyltransferase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0016746	transferase activity, transferring acyl groups	IEA	molecular function
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0019706	protein-cysteine S-palmitoyltransferase activity	IEA	molecular function
GO:0030660	Golgi-associated vesicle membrane	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0000139	Golgi membrane	IEA	cellular component
GO:0016409	palmitoyltransferase activity	IEA	molecular function
GO:0015095	magnesium ion transmembrane transporter activity	IEA	molecular function
GO:0030659	cytoplasmic vesicle membrane	IEA	cellular component
GO:0000139	Golgi membrane	IEA	cellular component
GO:1903830	magnesium ion transmembrane transport	IEA	biological process
GO:1903830	magnesium ion transmembrane transport	IEA	biological process
GO:1903830	magnesium ion transmembrane transport	IEA	biological process
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0016020	membrane	HDA	cellular component
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	HMP	biological process

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R