• Gene id: 54498

Gene Summary

• Gene Symbol: SMOX   Gene   UCSC   Ensembl
• Aliases: C20orf16, PAO, PAO-1, PAO1, PAOH, PAOH1, SMO
• Gene name: spermine oxidase
• Alternate names: spermine oxidase, flavin containing amine oxidase, flavin-containing spermine oxidase, polyamine oxidase 1, putative cyclin G1 interacting protein,
• Gene location: 20p13 (4148778: 4187746)     Exons: 9     NC_000020.11
• Gene summary(Entrez): Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, an
• OMIM: 608452

Protein Summary

• Protein general information: Q9NWM0  
  • Name: Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO 1) (PAOh1)
  • Length: 555  
  • Mass: 61819
  • Tissue specificity: Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line. {ECO
• Sequence:

  MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSHIGGRVQSVKLGHATFE
  LGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNHGRRIPKDVVEEFSDLYNEVYNLT
  QEFFRHDKPVNAESQNSVGVFTREEVRNRIRNDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEW
  TEIPGAHHIIPSGFMRVVELLAEGIPAHVIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDTGEGGQGGEEP
  RGGRWDEDEQWSVVVECEDCELIPADHVIVTVSLGVLKRQYTSFFRPGLPTEKVAAIHRLGIGTTDKIFLEFEEP
  FWGPECNSLQFVWEDEAESHTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMEKCDDEAVAEICTE
  MLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKY
  YSTTHGALLSGQREAARLIEMYRDLFQQGT

• Structural information:
  • Interpro: IPR002937  IPR036188  
  • STRING: ENSP00000478305
• Other Databases: GeneCards:  SMOX  Malacards:  SMOX

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0046592	polyamine oxidase activity	IBA	molecular function
GO:0016491	oxidoreductase activity	IBA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0052901	spermine:oxygen oxidoreductase (spermidine-forming) activity	IEA	molecular function
GO:0052894	norspermine:oxygen oxidoreductase activity	IEA	molecular function
GO:0052895	N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity	IEA	molecular function
GO:0052901	spermine:oxygen oxidoreductase (spermidine-forming) activity	TAS	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0006596	polyamine biosynthetic process	TAS	biological process
GO:0046592	polyamine oxidase activity	IEA	molecular function
GO:0046592	polyamine oxidase activity	IEA	molecular function
GO:0046208	spermine catabolic process	IEA	biological process
GO:0046208	spermine catabolic process	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0031965	nuclear membrane	IDA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0046208	spermine catabolic process	IEA	biological process
GO:0006598	polyamine catabolic process	IDA	biological process
GO:0046592	polyamine oxidase activity	IDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00330	Arginine and proline metabolism
hsa00410	beta-Alanine metabolism

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881