• Gene id: 54209

Gene Summary

• Gene Symbol: TREM2   Gene   UCSC   Ensembl
• Aliases: PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c
• Gene name: triggering receptor expressed on myeloid cells 2
• Alternate names: triggering receptor expressed on myeloid cells 2, triggering receptor expressed on monocytes 2, triggering receptor expressed on myeloid cells 2a,
• Gene location: 6p21.1 (41163115: 41158507)     Exons: 5     NC_000006.12
• Gene summary(Entrez): This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production o
• OMIM: 604610

Protein Summary

• Protein general information: Q9NZC2  
  • Name: Triggering receptor expressed on myeloid cells 2 (TREM 2) (Triggering receptor expressed on monocytes 2)
  • Length: 230  
  • Mass: 25447
  • Tissue specificity: Expressed in the brain, specifically in microglia and in the fusiform gyrus (at protein level) (PubMed
• Sequence:

  MEPLRLLILLFVTELSGAHNTTVFQGVAGQSLQVSCPYDSMKHWGRRKAWCRQLGEKGPCQRVVSTHNLWLLSFL
  RRWNGSTAITDDTLGGTLTITLRNLQPHDAGLYQCQSLHGSEADTLRKVLVEVLADPLDHRDAGDLWFPGESESF
  EDAHVEHSISRSLLEGEIPFPPTSILLLLACIFLIKILAASALWAAAWHGQKPGTHPPSELDCGHDPGYQLQTLP
  GLRDT

• Structural information:
  • Protein Domains: (29..11-)
    (/note="Ig-like-V-type")
  • Interpro: IPR036179  IPR013783  IPR013106  
  • PDB: 5ELI 5UD7 5UD8 6B8O
  • PDBsum: 5ELI 5UD7 5UD8 6B8O
  • STRING: ENSP00000362205
• Other Databases: GeneCards:  TREM2  Malacards:  TREM2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0071813	lipoprotein particle binding	IDA	molecular function
GO:0008035	high-density lipoprotein particle binding	IDA	molecular function
GO:0034189	very-low-density lipoprotein particle binding	IDA	molecular function
GO:0030169	low-density lipoprotein particle binding	IDA	molecular function
GO:0008289	lipid binding	TAS	molecular function
GO:0001540	amyloid-beta binding	IPI	molecular function
GO:1990782	protein tyrosine kinase binding	ISS	molecular function
GO:0038023	signaling receptor activity	ISS	molecular function
GO:0034185	apolipoprotein binding	IPI	molecular function
GO:0034185	apolipoprotein binding	IPI	molecular function
GO:0034185	apolipoprotein binding	IPI	molecular function
GO:0034185	apolipoprotein binding	IPI	molecular function
GO:0034186	apolipoprotein A-I binding	IPI	molecular function
GO:0044877	protein-containing complex binding	IPI	molecular function
GO:1904646	cellular response to amyloid-beta	ISS	biological process
GO:0098657	import into cell	ISS	biological process
GO:0120035	regulation of plasma membrane bounded cell projection organization	IGI	biological process
GO:0120035	regulation of plasma membrane bounded cell projection organization	ISS	biological process
GO:1904141	positive regulation of microglial cell migration	ISS	biological process
GO:1904141	positive regulation of microglial cell migration	ISS	biological process
GO:1904141	positive regulation of microglial cell migration	ISS	biological process
GO:2001171	positive regulation of ATP biosynthetic process	ISS	biological process
GO:1902531	regulation of intracellular signal transduction	ISS	biological process
GO:1905291	positive regulation of CAMKK-AMPK signaling cascade	ISS	biological process
GO:1900223	positive regulation of amyloid-beta clearance	ISS	biological process
GO:1900223	positive regulation of amyloid-beta clearance	ISS	biological process
GO:1904093	negative regulation of autophagic cell death	ISS	biological process
GO:0010628	positive regulation of gene expression	ISS	biological process
GO:0010822	positive regulation of mitochondrion organization	ISS	biological process
GO:0050921	positive regulation of chemotaxis	ISS	biological process
GO:1901800	positive regulation of proteasomal protein catabolic process	ISS	biological process
GO:1901980	positive regulation of inward rectifier potassium channel activity	ISS	biological process
GO:0010468	regulation of gene expression	ISS	biological process
GO:0032008	positive regulation of TOR signaling	ISS	biological process
GO:0010507	negative regulation of autophagy	ISS	biological process
GO:0010507	negative regulation of autophagy	ISS	biological process
GO:0001934	positive regulation of protein phosphorylation	ISS	biological process
GO:0048143	astrocyte activation	ISS	biological process
GO:0001774	microglial cell activation	ISS	biological process
GO:0001774	microglial cell activation	ISS	biological process
GO:0001774	microglial cell activation	ISS	biological process
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	ISS	biological process
GO:0060075	regulation of resting membrane potential	ISS	biological process
GO:0071640	regulation of macrophage inflammatory protein 1 alpha production	ISS	biological process
GO:0032006	regulation of TOR signaling	ISS	biological process
GO:0032675	regulation of interleukin-6 production	ISS	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0005543	phospholipid binding	IDA	molecular function
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	biological process
GO:0030316	osteoclast differentiation	IMP	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0008289	lipid binding	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0006959	humoral immune response	TAS	biological process
GO:0030316	osteoclast differentiation	IMP	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0045087	innate immune response	TAS	biological process
GO:0050776	regulation of immune response	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:2001171	positive regulation of ATP biosynthetic process	IEA	biological process
GO:1905291	positive regulation of CAMKK-AMPK signaling cascade	IEA	biological process
GO:1904646	cellular response to amyloid-beta	IEA	biological process
GO:1904141	positive regulation of microglial cell migration	IEA	biological process
GO:1903980	positive regulation of microglial cell activation	IEA	biological process
GO:0150078	positive regulation of neuroinflammatory response	IEA	biological process
GO:0150076	neuroinflammatory response	IEA	biological process
GO:0098657	import into cell	IEA	biological process
GO:0070891	lipoteichoic acid binding	IEA	molecular function
GO:0070392	detection of lipoteichoic acid	IEA	biological process
GO:0050921	positive regulation of chemotaxis	IEA	biological process
GO:0045672	positive regulation of osteoclast differentiation	IEA	biological process
GO:0043066	negative regulation of apoptotic process	IEA	biological process
GO:0038023	signaling receptor activity	IEA	molecular function
GO:0032733	positive regulation of interleukin-10 production	IEA	biological process
GO:0032720	negative regulation of tumor necrosis factor production	IEA	biological process
GO:0032691	negative regulation of interleukin-1 beta production	IEA	biological process
GO:0032497	detection of lipopolysaccharide	IEA	biological process
GO:0032008	positive regulation of TOR signaling	IEA	biological process
GO:0010822	positive regulation of mitochondrion organization	IEA	biological process
GO:0010628	positive regulation of gene expression	IEA	biological process
GO:0002931	response to ischemia	IEA	biological process
GO:1990782	protein tyrosine kinase binding	IEA	molecular function
GO:1904093	negative regulation of autophagic cell death	IEA	biological process
GO:1902531	regulation of intracellular signal transduction	IEA	biological process
GO:1901980	positive regulation of inward rectifier potassium channel activity	IEA	biological process
GO:1901800	positive regulation of proteasomal protein catabolic process	IEA	biological process
GO:1901224	positive regulation of NIK/NF-kappaB signaling	IEA	biological process
GO:1900223	positive regulation of amyloid-beta clearance	IEA	biological process
GO:0150062	complement-mediated synapse pruning	IEA	biological process
GO:0120035	regulation of plasma membrane bounded cell projection organization	IEA	biological process
GO:0097242	amyloid-beta clearance	IEA	biological process
GO:0071640	regulation of macrophage inflammatory protein 1 alpha production	IEA	biological process
GO:0071224	cellular response to peptidoglycan	IEA	biological process
GO:0071223	cellular response to lipoteichoic acid	IEA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IEA	biological process
GO:0061518	microglial cell proliferation	IEA	biological process
GO:0060100	positive regulation of phagocytosis, engulfment	IEA	biological process
GO:0060075	regulation of resting membrane potential	IEA	biological process
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IEA	biological process
GO:0048143	astrocyte activation	IEA	biological process
GO:0045088	regulation of innate immune response	IEA	biological process
GO:0043277	apoptotic cell clearance	IEA	biological process
GO:0042834	peptidoglycan binding	IEA	molecular function
GO:0042742	defense response to bacterium	IEA	biological process
GO:0034241	positive regulation of macrophage fusion	IEA	biological process
GO:0032675	regulation of interleukin-6 production	IEA	biological process
GO:0032499	detection of peptidoglycan	IEA	biological process
GO:0032006	regulation of TOR signaling	IEA	biological process
GO:0010507	negative regulation of autophagy	IEA	biological process
GO:0010468	regulation of gene expression	IEA	biological process
GO:0006911	phagocytosis, engulfment	IEA	biological process
GO:0005887	integral component of plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0002282	microglial cell activation involved in immune response	IEA	biological process
GO:0001934	positive regulation of protein phosphorylation	IEA	biological process
GO:0001774	microglial cell activation	IEA	biological process
GO:0001530	lipopolysaccharide binding	IEA	molecular function
GO:0097110	scaffold protein binding	IPI	molecular function
GO:0002588	positive regulation of antigen processing and presentation of peptide antigen via MHC class II	IDA	biological process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	biological process
GO:0050850	positive regulation of calcium-mediated signaling	IDA	biological process
GO:2000350	positive regulation of CD40 signaling pathway	IDA	biological process
GO:0016021	integral component of membrane	IDA	cellular component
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0097028	dendritic cell differentiation	IDA	biological process
GO:1903078	positive regulation of protein localization to plasma membrane	IDA	biological process
GO:1903082	positive regulation of C-C chemokine receptor CCR7 signaling pathway	IDA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0031226	intrinsic component of plasma membrane	IMP	cellular component
GO:0050714	positive regulation of protein secretion	IMP	biological process
GO:0043277	apoptotic cell clearance	ISS	biological process
GO:1903980	positive regulation of microglial cell activation	IMP	biological process
GO:0034241	positive regulation of macrophage fusion	ISS	biological process
GO:0005886	plasma membrane	IMP	cellular component
GO:1901076	positive regulation of engulfment of apoptotic cell	IMP	biological process
GO:0060100	positive regulation of phagocytosis, engulfment	IMP	biological process
GO:0005886	plasma membrane	IMP	cellular component
GO:0005886	plasma membrane	IMP	cellular component
GO:0071813	lipoprotein particle binding	IDA	molecular function
GO:0008035	high-density lipoprotein particle binding	IDA	molecular function
GO:0034189	very-low-density lipoprotein particle binding	IDA	molecular function
GO:0030169	low-density lipoprotein particle binding	IDA	molecular function
GO:0008289	lipid binding	TAS	molecular function
GO:0001540	amyloid-beta binding	IPI	molecular function
GO:1990782	protein tyrosine kinase binding	ISS	molecular function
GO:0038023	signaling receptor activity	ISS	molecular function
GO:0034185	apolipoprotein binding	IPI	molecular function
GO:0034185	apolipoprotein binding	IPI	molecular function
GO:0034185	apolipoprotein binding	IPI	molecular function
GO:0034185	apolipoprotein binding	IPI	molecular function
GO:0034186	apolipoprotein A-I binding	IPI	molecular function
GO:0044877	protein-containing complex binding	IPI	molecular function
GO:1904646	cellular response to amyloid-beta	ISS	biological process
GO:0098657	import into cell	ISS	biological process
GO:0120035	regulation of plasma membrane bounded cell projection organization	IGI	biological process
GO:0120035	regulation of plasma membrane bounded cell projection organization	ISS	biological process
GO:1904141	positive regulation of microglial cell migration	ISS	biological process
GO:1904141	positive regulation of microglial cell migration	ISS	biological process
GO:1904141	positive regulation of microglial cell migration	ISS	biological process
GO:2001171	positive regulation of ATP biosynthetic process	ISS	biological process
GO:1902531	regulation of intracellular signal transduction	ISS	biological process
GO:1905291	positive regulation of CAMKK-AMPK signaling cascade	ISS	biological process
GO:1900223	positive regulation of amyloid-beta clearance	ISS	biological process
GO:1900223	positive regulation of amyloid-beta clearance	ISS	biological process
GO:1904093	negative regulation of autophagic cell death	ISS	biological process
GO:0010628	positive regulation of gene expression	ISS	biological process
GO:0010822	positive regulation of mitochondrion organization	ISS	biological process
GO:0050921	positive regulation of chemotaxis	ISS	biological process
GO:1901800	positive regulation of proteasomal protein catabolic process	ISS	biological process
GO:1901980	positive regulation of inward rectifier potassium channel activity	ISS	biological process
GO:0010468	regulation of gene expression	ISS	biological process
GO:0032008	positive regulation of TOR signaling	ISS	biological process
GO:0010507	negative regulation of autophagy	ISS	biological process
GO:0010507	negative regulation of autophagy	ISS	biological process
GO:0001934	positive regulation of protein phosphorylation	ISS	biological process
GO:0048143	astrocyte activation	ISS	biological process
GO:0001774	microglial cell activation	ISS	biological process
GO:0001774	microglial cell activation	ISS	biological process
GO:0001774	microglial cell activation	ISS	biological process
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	ISS	biological process
GO:0060075	regulation of resting membrane potential	ISS	biological process
GO:0071640	regulation of macrophage inflammatory protein 1 alpha production	ISS	biological process
GO:0032006	regulation of TOR signaling	ISS	biological process
GO:0032675	regulation of interleukin-6 production	ISS	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0005543	phospholipid binding	IDA	molecular function
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	biological process
GO:0030316	osteoclast differentiation	IMP	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0008289	lipid binding	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0006959	humoral immune response	TAS	biological process
GO:0030316	osteoclast differentiation	IMP	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0045087	innate immune response	TAS	biological process
GO:0050776	regulation of immune response	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:2001171	positive regulation of ATP biosynthetic process	IEA	biological process
GO:1905291	positive regulation of CAMKK-AMPK signaling cascade	IEA	biological process
GO:1904646	cellular response to amyloid-beta	IEA	biological process
GO:1904141	positive regulation of microglial cell migration	IEA	biological process
GO:1903980	positive regulation of microglial cell activation	IEA	biological process
GO:0150078	positive regulation of neuroinflammatory response	IEA	biological process
GO:0150076	neuroinflammatory response	IEA	biological process
GO:0098657	import into cell	IEA	biological process
GO:0070891	lipoteichoic acid binding	IEA	molecular function
GO:0070392	detection of lipoteichoic acid	IEA	biological process
GO:0050921	positive regulation of chemotaxis	IEA	biological process
GO:0045672	positive regulation of osteoclast differentiation	IEA	biological process
GO:0043066	negative regulation of apoptotic process	IEA	biological process
GO:0038023	signaling receptor activity	IEA	molecular function
GO:0032733	positive regulation of interleukin-10 production	IEA	biological process
GO:0032720	negative regulation of tumor necrosis factor production	IEA	biological process
GO:0032691	negative regulation of interleukin-1 beta production	IEA	biological process
GO:0032497	detection of lipopolysaccharide	IEA	biological process
GO:0032008	positive regulation of TOR signaling	IEA	biological process
GO:0010822	positive regulation of mitochondrion organization	IEA	biological process
GO:0010628	positive regulation of gene expression	IEA	biological process
GO:0002931	response to ischemia	IEA	biological process
GO:1990782	protein tyrosine kinase binding	IEA	molecular function
GO:1904093	negative regulation of autophagic cell death	IEA	biological process
GO:1902531	regulation of intracellular signal transduction	IEA	biological process
GO:1901980	positive regulation of inward rectifier potassium channel activity	IEA	biological process
GO:1901800	positive regulation of proteasomal protein catabolic process	IEA	biological process
GO:1901224	positive regulation of NIK/NF-kappaB signaling	IEA	biological process
GO:1900223	positive regulation of amyloid-beta clearance	IEA	biological process
GO:0150062	complement-mediated synapse pruning	IEA	biological process
GO:0120035	regulation of plasma membrane bounded cell projection organization	IEA	biological process
GO:0097242	amyloid-beta clearance	IEA	biological process
GO:0071640	regulation of macrophage inflammatory protein 1 alpha production	IEA	biological process
GO:0071224	cellular response to peptidoglycan	IEA	biological process
GO:0071223	cellular response to lipoteichoic acid	IEA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IEA	biological process
GO:0061518	microglial cell proliferation	IEA	biological process
GO:0060100	positive regulation of phagocytosis, engulfment	IEA	biological process
GO:0060075	regulation of resting membrane potential	IEA	biological process
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IEA	biological process
GO:0048143	astrocyte activation	IEA	biological process
GO:0045088	regulation of innate immune response	IEA	biological process
GO:0043277	apoptotic cell clearance	IEA	biological process
GO:0042834	peptidoglycan binding	IEA	molecular function
GO:0042742	defense response to bacterium	IEA	biological process
GO:0034241	positive regulation of macrophage fusion	IEA	biological process
GO:0032675	regulation of interleukin-6 production	IEA	biological process
GO:0032499	detection of peptidoglycan	IEA	biological process
GO:0032006	regulation of TOR signaling	IEA	biological process
GO:0010507	negative regulation of autophagy	IEA	biological process
GO:0010468	regulation of gene expression	IEA	biological process
GO:0006911	phagocytosis, engulfment	IEA	biological process
GO:0005887	integral component of plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0002282	microglial cell activation involved in immune response	IEA	biological process
GO:0001934	positive regulation of protein phosphorylation	IEA	biological process
GO:0001774	microglial cell activation	IEA	biological process
GO:0001530	lipopolysaccharide binding	IEA	molecular function
GO:0097110	scaffold protein binding	IPI	molecular function
GO:0002588	positive regulation of antigen processing and presentation of peptide antigen via MHC class II	IDA	biological process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	biological process
GO:0050850	positive regulation of calcium-mediated signaling	IDA	biological process
GO:2000350	positive regulation of CD40 signaling pathway	IDA	biological process
GO:0016021	integral component of membrane	IDA	cellular component
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0097028	dendritic cell differentiation	IDA	biological process
GO:1903078	positive regulation of protein localization to plasma membrane	IDA	biological process
GO:1903082	positive regulation of C-C chemokine receptor CCR7 signaling pathway	IDA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0031226	intrinsic component of plasma membrane	IMP	cellular component
GO:0050714	positive regulation of protein secretion	IMP	biological process
GO:0043277	apoptotic cell clearance	ISS	biological process
GO:1903980	positive regulation of microglial cell activation	IMP	biological process
GO:0034241	positive regulation of macrophage fusion	ISS	biological process
GO:0005886	plasma membrane	IMP	cellular component
GO:1901076	positive regulation of engulfment of apoptotic cell	IMP	biological process
GO:0060100	positive regulation of phagocytosis, engulfment	IMP	biological process
GO:0005886	plasma membrane	IMP	cellular component
GO:0005886	plasma membrane	IMP	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04380	Osteoclast differentiation

Diseases

Associated diseases	References
Nasu-Hakola disease	KEGG:H00438
Nasu-Hakola disease	KEGG:H00438
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Asthenoozoospermia	MIK: 32167074
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
32167074	Asthenoozoospermia			12 (6controls, 6 cases)	Male infertility	Microarray