• Gene id: 5412

Gene Summary

• Gene Symbol: UBL3   Gene   UCSC   Ensembl
• Aliases: HCG-1, PNSC1
• Gene name: ubiquitin like 3
• Alternate names: ubiquitin-like protein 3, MUB, hsMUB, membrane-anchored ubiquitin-fold protein, protein HCG-1,
• Gene location: 13q12.3 (143636018: 143653729)     Exons: 4     NC_000008.11
• OMIM: 604711

Protein Summary

• Protein general information: O95164  
  • Name: Ubiquitin like protein 3 (Membrane anchored ubiquitin fold protein) (HsMUB) (MUB) (Protein HCG 1)
  • Length: 117  
  • Mass: 13157
  • Tissue specificity: Ubiquitous. {ECO
• Sequence:

  MSSNVPADMINLRLILVSGKTKEFLFSPNDSASDIAKHVYDNWPMDWEEEQVSSPNILRLIYQGRFLHGNVTLGA
  LKLPFGKTTVMHLVARETLPEPNSQGQRNREKTGESNCCVIL

• Structural information:
  • Protein Domains: (10..8-)
    (/note="Ubiquitin-like-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00214"-)
  • Interpro: IPR017000  IPR000626  IPR029071  IPR040015  IPR039540  
  • Prosite: PS50053
  • PDB: 2GOW
  • PDBsum: 2GOW
  • STRING: ENSP00000370055
• Other Databases: GeneCards:  UBL3  Malacards:  UBL3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005622	intracellular	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray