• Gene id: 5362

Gene Summary

• Gene Symbol: PLXNA2   Gene   UCSC   Ensembl
• Aliases: OCT, PLXN2
• Gene name: plexin A2
• Alternate names: plexin-A2, plexin 2, semaphorin receptor OCT, transmembrane protein OCT,
• Gene location: 1q32.2 (208244383: 208022241)     Exons: 34     NC_000001.11
• Gene summary(Entrez): This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphori
• OMIM: 601053

Protein Summary

• Protein general information: O75051  
  • Name: Plexin A2 (Semaphorin receptor OCT)
  • Length: 1894  
  • Mass: 211104
  • Tissue specificity: Detected in fetal brain. {ECO
• Sequence:

  MEQRRPWPRALEVDSRSVVLLSVVWVLLAPPAAGMPQFSTFHSENRDWTFNHLTVHQGTGAVYVGAINRVYKLTG
  NLTIQVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVE
  PSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSL
  IKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPEGVAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGC
  TRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQKQYHHPPDDSALCAFPIRAINLQIKERLQSCY
  QGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRMTSVASYVYNGYSVVFVGT
  KSGKLKKIRADGPPHGGVQYEMVSVLKDGSPILRDMAFSIDQRYLYVMSERQVTRVPVESCEQYTTCGECLSSGD
  PHCGWCALHNMCSRRDKCQQAWEPNRFAASISQCVSLAVHPSSISVSEHSRLLSLVVSDAPDLSAGIACAFGNLT
  EVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWC
  KYRNLCTHDPTTCSFQEGRINISEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAIHRV
  PALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADRKFECGW
  CSGERRCTLHQHCTSPSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVP
  CTPLPGEYIIAEQIVCEMGHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLNPIRGPESGGTMVTIT
  GHYLGAGSSVAVYLGNQTCEFYGRSMSEIVCVSPPSSNGLGPVPVSVSVDRAHVDSNLQFEYIDDPRVQRIEPEW
  SIASGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCKVVNTTTLTCLAPSLTTDYRPGLDTVERPDEFGFVFNN
  VQSLLIYNDTKFIYYPNPTFELLSPTGVLDQKPGSPIILKGKNLCPPASGGAKLNYTVLIGETPCAVTVSETQLL
  CEPPNLTGQHKVMVHVGGMVFSPGSVSVISDSLLTLPAIVSIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQ
  MQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEVQGNGQQHVEK
  ALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKL
  LLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTL
  ILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRIARVVLQDEDITTKIE
  GDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRAPMITPDLESGVK
  VWHLVKNHDHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQAD
  RHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLY
  AKDIPSYKSWVERYYADIAKLPAISDQDMNAYLAEQSRLHAVEFNMLSALNEIYSYVSKYSEELIGALEQDEQAR
  RQRLAYKVEQLINAMSIES

• Structural information:
  • Protein Domains: (35..50-)
    (/note="Sema-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00352-)
    (858..95-)
    (/note="IPT/TIG-1)
    (954..103-)
    (/note="IPT/TIG-2)
    (1041..113-)
    (/note="IPT/TIG-3)
    (1143..122-)
    (/note="IPT/TIG-4")
  • Interpro: IPR013783  IPR014756  IPR002909  IPR031148  IPR042826   IPR013548  IPR002165  IPR016201  IPR008936  IPR001627  IPR036352  IPR041019  IPR041362  IPR015943  
  • Prosite: PS51004
  • CDD: cd11272
  • PDB: 3Q3J
  • PDBsum: 3Q3J
  • DIP: 31672
  • STRING: ENSP00000356000
• Other Databases: GeneCards:  PLXNA2  Malacards:  PLXNA2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002116	semaphorin receptor complex	IBA	cellular component
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0007162	negative regulation of cell adhesion	IBA	biological process
GO:0017154	semaphorin receptor activity	IBA	molecular function
GO:0043087	regulation of GTPase activity	IBA	biological process
GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IBA	biological process
GO:0008360	regulation of cell shape	IBA	biological process
GO:0030334	regulation of cell migration	IBA	biological process
GO:0050772	positive regulation of axonogenesis	IBA	biological process
GO:0030334	regulation of cell migration	ISS	biological process
GO:0071526	semaphorin-plexin signaling pathway	ISS	biological process
GO:0017154	semaphorin receptor activity	ISS	molecular function
GO:0005887	integral component of plasma membrane	ISS	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0017154	semaphorin receptor activity	IEA	molecular function
GO:0071526	semaphorin-plexin signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0060174	limb bud formation	IEA	biological process
GO:0030334	regulation of cell migration	IEA	biological process
GO:0021915	neural tube development	IEA	biological process
GO:0071526	semaphorin-plexin signaling pathway	IEA	biological process
GO:0060037	pharyngeal system development	IEA	biological process
GO:0051642	centrosome localization	IEA	biological process
GO:0042802	identical protein binding	IEA	molecular function
GO:0021935	cerebellar granule cell precursor tangential migration	IEA	biological process
GO:0017154	semaphorin receptor activity	IEA	molecular function
GO:0007166	cell surface receptor signaling pathway	IEA	biological process
GO:0005887	integral component of plasma membrane	IEA	cellular component
GO:0001756	somitogenesis	IEA	biological process
GO:0002116	semaphorin receptor complex	TAS	cellular component
GO:0005886	plasma membrane	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04360	Axon guidance

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq