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Gene id 5335
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol PLCG1   Gene   UCSC   Ensembl
Aliases NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1
Gene name phospholipase C gamma 1
Alternate names 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate, PLC-148, PLC-gamma-1, inositoltrisphosphohydrolase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, phosphoinosit,
Gene location 20q12 (41137518: 41177625)     Exons: 32     NC_000020.11
Gene summary(Entrez) The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction
OMIM 172420

Protein Summary

Gene ontology

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GO accessionTerm nameEvidence codeGo category

KEGG pathways

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Pathway idPathway name
hsa01100Metabolic pathways
hsa04066HIF-1 signaling pathway
hsa04020Calcium signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04072Phospholipase D signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04658Th1 and Th2 cell differentiation
hsa04659Th17 cell differentiation
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04919Thyroid hormone signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04750Inflammatory mediator regulation of TRP channels
hsa04360Axon guidance
hsa05200Pathways in cancer
hsa05206MicroRNAs in cancer
hsa05205Proteoglycans in cancer
hsa05231Choline metabolism in cancer
hsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05225Hepatocellular carcinoma
hsa05214Glioma
hsa05223Non-small cell lung cancer
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05110Vibrio cholerae infection
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05135Yersinia infection
hsa05170Human immunodeficiency virus 1 infection
hsa05167Kaposi sarcoma-associated herpesvirus infection
hsa01521EGFR tyrosine kinase inhibitor resistance
hsa01100Metabolic pathways
hsa05200Pathways in cancer
hsa04750Inflammatory mediator regulation of TRP channels
hsa04020Calcium signaling pathway
hsa05206MicroRNAs in cancer
hsa04015Rap1 signaling pathway
hsa04935Growth hormone synthesis, secretion and action
hsa04066HIF-1 signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa05131Shigellosis
hsa04072Phospholipase D signaling pathway
hsa04014Ras signaling pathway
hsa05225Hepatocellular carcinoma
hsa05205Proteoglycans in cancer
hsa05170Human immunodeficiency virus 1 infection
hsa05223Non-small cell lung cancer
hsa05110Vibrio cholerae infection
hsa04070Phosphatidylinositol signaling system
hsa04666Fc gamma R-mediated phagocytosis
hsa05214Glioma
hsa05167Kaposi sarcoma-associated herpesvirus infection
hsa04722Neurotrophin signaling pathway
hsa04659Th17 cell differentiation
hsa04360Axon guidance
hsa05135Yersinia infection
hsa01521EGFR tyrosine kinase inhibitor resistance
hsa04670Leukocyte transendothelial migration
hsa04370VEGF signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04012ErbB signaling pathway
hsa00562Inositol phosphate metabolism
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04064NF-kappa B signaling pathway
hsa05231Choline metabolism in cancer
hsa04664Fc epsilon RI signaling pathway
hsa04660T cell receptor signaling pathway
hsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa04658Th1 and Th2 cell differentiation

Diseases

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Associated diseases References
Multiple sclerosis GAD: 16764945
Bipolar disorder GAD: 11353454
Psychological disorders GAD: 19086053
Chronic renal failure GAD: 21085059
Sperm-borne oocyte activating defects MIK: 29397567
Fertilizing defects MIK: 29397567
Sperm-borne oocyte activating defects MIK: 29397567
Fertilization failure MIK: 29397567
Male infertility MIK: 29397567

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
29397567 Sperm-born
e oocyte a
ctivating
defects, f
ertilizati
on failure
, male inf
ertility
30 (15 fertile
men (control gr
oup) and 15 pat
ients with prev
ious fertilizat
ion failure fol
lowing ICSI (FF
group))
 Male infertility WBP2NL
PLCG1
 Show abstract