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Gene id 5300
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol PIN1   Gene   UCSC   Ensembl
Aliases DOD, UBL5
Gene name peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Alternate names peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, PPIase Pin1, protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1, protein interacting with never in mitosis A1, rotamase Pin1,
Gene location 19p13.2 (9835206: 9849688)     Exons: 6     NC_000019.10
Gene summary(Entrez) Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-ph
OMIM 601052

Protein Summary
Protein general information Q13526  

Name: Peptidyl prolyl cis trans isomerase NIMA interacting 1 (EC 5.2.1.8) (Peptidyl prolyl cis trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1)

Length: 163  Mass: 18243

Tissue specificity: The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells. {ECO

Sequence MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQ
EKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPV
FTDSGIHIILRTE
Structural information
Protein Domains
 (5..3-)
(/note="WW-)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00224-)
(52..16-)
(/note="PpiC-)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00278"-)
Interpro:  IPR000297  IPR023058  IPR001202  IPR036020  
Prosite:   PS01096 PS50198 PS01159 PS50020
CDD:   cd00201

PDB:  		 1F8A 1I6C 1I8G 1I8H 1NMV 1NMW 1PIN 1ZCN 2F21 2ITK 2KBU 2KCF 2LB3 2M8I 2M8J 2M9E 2M9F 2M9I 2M9J 2N1O 2Q5A 2RUC 2RUD 2RUQ 2RUR 2XP3 2XP4 2XP5 2XP6 2XP7 2XP8 2XP9 2XPA 2XPB 2ZQS 2ZQT 2ZQU 2ZQV 2ZR4 2ZR5 2ZR6 3I6C 3IK8 3IKD 3IKG 3JYJ 3KAB 3KAC 3KAD 3KAF 3KAG 3KAH 3KAI 3KCE 3NTP 3ODK 3OOB 3TC5 3TCZ 3TDB 3WH0 4GWT 4GWV 4QI
PDBsum:   1F8A 1I6C 1I8G 1I8H 1NMV 1NMW 1PIN 1ZCN 2F21 2ITK 2KBU 2KCF 2LB3 2M8I 2M8J 2M9E 2M9F 2M9I 2M9J 2N1O 2Q5A 2RUC 2RUD 2RUQ 2RUR 2XP3 2XP4 2XP5 2XP6 2XP7 2XP8 2XP9 2XPA 2XPB 2ZQS 2ZQT 2ZQU 2ZQV 2ZR4 2ZR5 2ZR6 3I6C 3IK8 3IKD 3IKG 3JYJ 3KAB 3KAC 3KAD 3KAF 3KAG 3KAH 3KAI 3KCE 3NTP 3ODK 3OOB 3TC5 3TCZ 3TDB 3WH0 4GWT 4GWV 4QI

DIP:  
29306
MINT:  
STRING:   ENSP00000247970
Other Databases GeneCards:  PIN1  Malacards:  PIN1

Gene ontology

Expand All | Collapse All
GO accessionTerm nameEvidence codeGo category
GO:0005634 nucleus
 IDA cellular component
GO:0005737 cytoplasm
 IDA cellular component
GO:0003755 peptidyl-prolyl cis-trans
isomerase activity
 NAS molecular function
GO:0003755 peptidyl-prolyl cis-trans
isomerase activity
 TAS molecular function
GO:0048156 tau protein binding
 NAS molecular function
GO:0051219 phosphoprotein binding
 ISS molecular function
GO:0010468 regulation of gene expres
sion
 IDA biological process
GO:0032092 positive regulation of pr
otein binding
 IDA biological process
GO:0001932 regulation of protein pho
sphorylation
 IDA biological process
GO:0046785 microtubule polymerizatio
n
 IDA NOT|biological process
GO:0035307 positive regulation of pr
otein dephosphorylation
 TAS biological process
GO:0005634 nucleus
 TAS cellular component
GO:0050815 phosphoserine residue bin
ding
 IDA molecular function
GO:0042177 negative regulation of pr
otein catabolic process
 IDA biological process
GO:0003755 peptidyl-prolyl cis-trans
isomerase activity
 TAS molecular function
GO:0003774 motor activity
 ISS molecular function
GO:0008013 beta-catenin binding
 IPI molecular function
GO:0008013 beta-catenin binding
 ISS molecular function
GO:0050821 protein stabilization
 IDA biological process
GO:0032091 negative regulation of pr
otein binding
 IDA biological process
GO:0005829 cytosol
 ISS cellular component
GO:0000413 protein peptidyl-prolyl i
somerization
 TAS biological process
GO:1900180 regulation of protein loc
alization to nucleus
 IDA biological process
GO:0045944 positive regulation of tr
anscription by RNA polyme
rase II
 IDA biological process
GO:0090263 positive regulation of ca
nonical Wnt signaling pat
hway
 IDA biological process
GO:0050808 synapse organization
 ISS biological process
GO:0050821 protein stabilization
 ISS biological process
GO:0030182 neuron differentiation
 ISS biological process
GO:0005634 nucleus
 IBA cellular component
GO:0003755 peptidyl-prolyl cis-trans
isomerase activity
 IBA molecular function
GO:0005829 cytosol
 IBA cellular component
GO:0001666 response to hypoxia
 IDA biological process
GO:0005737 cytoplasm
 IDA cellular component
GO:0005634 nucleus
 IDA cellular component
GO:0005515 protein binding
 IPI molecular function
GO:1902430 negative regulation of am
yloid-beta formation
 ISS biological process
GO:1902430 negative regulation of am
yloid-beta formation
 IMP biological process
GO:0031647 regulation of protein sta
bility
 IMP biological process
GO:0016859 cis-trans isomerase activ
ity
 IMP molecular function
GO:0003755 peptidyl-prolyl cis-trans
isomerase activity
 IEA molecular function
GO:0003755 peptidyl-prolyl cis-trans
isomerase activity
 IEA molecular function
GO:0007049 cell cycle
 IEA biological process
GO:0016853 isomerase activity
 IEA molecular function
GO:0005737 cytoplasm
 IEA cellular component
GO:0005634 nucleus
 IEA cellular component
GO:0005634 nucleus
 TAS cellular component
GO:0007088 regulation of mitotic nuc
lear division
 TAS biological process
GO:0003755 peptidyl-prolyl cis-trans
isomerase activity
 IEA molecular function
GO:0030496 midbody
 IDA cellular component
GO:0032465 regulation of cytokinesis
 IGI biological process
GO:0032465 regulation of cytokinesis
 IMP biological process
GO:0001934 positive regulation of pr
otein phosphorylation
 IGI biological process
GO:0003755 peptidyl-prolyl cis-trans
isomerase activity
 EXP molecular function
GO:0032480 negative regulation of ty
pe I interferon productio
n
 TAS biological process
GO:1901796 regulation of signal tran
sduction by p53 class med
iator
 TAS biological process
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0043005 neuron projection
 IEA cellular component
GO:0005829 cytosol
 IEA cellular component
GO:0061051 positive regulation of ce
ll growth involved in car
diac muscle cell developm
ent
 IEA biological process
GO:0043525 positive regulation of ne
uron apoptotic process
 IEA biological process
GO:0043524 negative regulation of ne
uron apoptotic process
 IEA biological process
GO:0035307 positive regulation of pr
otein dephosphorylation
 IEA biological process
GO:0005739 mitochondrion
 IEA cellular component
GO:0005737 cytoplasm
 IEA cellular component
GO:0005634 nucleus
 IEA cellular component
GO:0001934 positive regulation of pr
otein phosphorylation
 IEA biological process
GO:0003755 peptidyl-prolyl cis-trans
isomerase activity
 IDA molecular function
GO:0050815 phosphoserine residue bin
ding
 IDA molecular function
GO:0050816 phosphothreonine residue
binding
 IDA molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0031434 mitogen-activated protein
kinase kinase binding
 IPI molecular function
GO:0032794 GTPase activating protein
binding
 IPI molecular function
GO:0050816 phosphothreonine residue
binding
 IPI molecular function
GO:0051443 positive regulation of ub
iquitin-protein transfera
se activity
 IDA biological process
GO:2000146 negative regulation of ce
ll motility
 IDA biological process
GO:0005634 nucleus
 IDA cellular component
GO:0030512 negative regulation of tr
ansforming growth factor
beta receptor signaling p
athway
 IDA biological process
GO:0060393 regulation of pathway-res
tricted SMAD protein phos
phorylation
 IDA biological process
GO:0070373 negative regulation of ER
K1 and ERK2 cascade
 IDA biological process
GO:0043547 positive regulation of GT
Pase activity
 IMP biological process
GO:0016607 nuclear speck
 IEA cellular component
GO:0005737 cytoplasm
 IEA cellular component
GO:0005634 nucleus
 IEA cellular component
GO:0005654 nucleoplasm
 IDA cellular component
GO:0005829 cytosol
 IDA cellular component
GO:0036064 ciliary basal body
 IDA cellular component
GO:0036064 ciliary basal body
 IDA cellular component
GO:0005515 protein binding
 IPI molecular function
GO:0099524 postsynaptic cytosol
 IDA cellular component
GO:0098978 glutamatergic synapse
 IDA cellular component
GO:0098978 glutamatergic synapse
 IDA cellular component
GO:0098978 glutamatergic synapse
 IDA cellular component
GO:0099524 postsynaptic cytosol
 IDA cellular component
GO:0099524 postsynaptic cytosol
 IDA cellular component

KEGG pathways

Expand All | Collapse All

Pathway idPathway name
hsa04622RIG-I-like receptor signaling pathway

Diseases

Expand All | Collapse All
Associated diseases References
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Teratozoospermia MIK: 17327269

PubMed references

Expand All | Collapse All
PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia
13 (5 controls,
8 cases)
 Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
17327269 Teratozoos
permia
19 (6 controls
, 13 cases)
 Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract