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Gene id 5291
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol PIK3CB   Gene   UCSC   Ensembl
Aliases P110BETA, PI3K, PI3KBETA, PIK3C1
Gene name phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Alternate names phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, PI3-kinase p110 subunit beta, PI3-kinase subunit beta, PI3K-beta, PtdIns-3-kinase p110, phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, phosphoinositid,
Gene location 3q22.3 (138834937: 138652697)     Exons: 27     NC_000009.12
Gene summary(Entrez) This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encod
OMIM 602925

Protein Summary

Gene ontology

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GO accessionTerm nameEvidence codeGo category

KEGG pathways

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Pathway idPathway name
hsa01100Metabolic pathways
hsa00010Glycolysis / Gluconeogenesis
hsa00020Citrate cycle
hsa00052Galactose metabolism
hsa00520Amino sugar and nucleotide sugar metabolism
hsa00630Glyoxylate and dicarboxylate metabolism
hsa00562Inositol phosphate metabolism
hsa00190Oxidative phosphorylation
hsa00190Oxidative phosphorylation
hsa00190Oxidative phosphorylation
hsa00190Oxidative phosphorylation
hsa00910Nitrogen metabolism
hsa00120Primary bile acid biosynthesis
hsa00140Steroid hormone biosynthesis
hsa00140Steroid hormone biosynthesis
hsa00564Glycerophospholipid metabolism
hsa00564Glycerophospholipid metabolism
hsa00230Purine metabolism
hsa00250Alanine, aspartate and glutamate metabolism
hsa00270Cysteine and methionine metabolism
hsa00280Valine, leucine and isoleucine degradation
hsa00330Arginine and proline metabolism
hsa00350Tyrosine metabolism
hsa00400Phenylalanine, tyrosine and tryptophan biosynthesis
hsa00480Glutathione metabolism
hsa00480Glutathione metabolism
hsa00513Various types of N-glycan biosynthesis
hsa00511Other glycan degradation
hsa00830Retinol metabolism
hsa00860Porphyrin and chlorophyll metabolism
hsa00900Terpenoid backbone biosynthesis
hsa00232Caffeine metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa03022Basal transcription factors
hsa03040Spliceosome
hsa03040Spliceosome
hsa03013RNA transport
hsa03013RNA transport
hsa03008Ribosome biogenesis in eukaryotes
hsa03008Ribosome biogenesis in eukaryotes
hsa04141Protein processing in endoplasmic reticulum
hsa04141Protein processing in endoplasmic reticulum
hsa04141Protein processing in endoplasmic reticulum
hsa04141Protein processing in endoplasmic reticulum
hsa04141Protein processing in endoplasmic reticulum
hsa04130SNARE interactions in vesicular transport
hsa04120Ubiquitin mediated proteolysis
hsa04120Ubiquitin mediated proteolysis
hsa03018RNA degradation
hsa03410Base excision repair
hsa03420Nucleotide excision repair
hsa03430Mismatch repair
hsa03440Homologous recombination
hsa03440Homologous recombination
hsa03460Fanconi anemia pathway
hsa03460Fanconi anemia pathway
hsa04014Ras signaling pathway
hsa04014Ras signaling pathway
hsa04014Ras signaling pathway
hsa04014Ras signaling pathway
hsa04014Ras signaling pathway
hsa04014Ras signaling pathway
hsa04014Ras signaling pathway
hsa04014Ras signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04015Rap1 signaling pathway
hsa04015Rap1 signaling pathway
hsa04010MAPK signaling pathway
hsa04010MAPK signaling pathway
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04012ErbB signaling pathway
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa04350TGF-beta signaling pathway
hsa04350TGF-beta signaling pathway
hsa04350TGF-beta signaling pathway
hsa04390Hippo signaling pathway
hsa04390Hippo signaling pathway
hsa04390Hippo signaling pathway
hsa04370VEGF signaling pathway
hsa04370VEGF signaling pathway
hsa04371Apelin signaling pathway
hsa04630JAK-STAT signaling pathway
hsa04630JAK-STAT signaling pathway
hsa04630JAK-STAT signaling pathway
hsa04630JAK-STAT signaling pathway
hsa04630JAK-STAT signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04668TNF signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04072Phospholipase D signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04024cAMP signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04150mTOR signaling pathway
hsa04140Autophagy - animal
hsa04210Apoptosis
hsa04218Cellular senescence
hsa04510Focal adhesion
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04810Regulation of actin cytoskeleton
hsa04611Platelet activation
hsa04620Toll-like receptor signaling pathway
hsa04625C-type lectin receptor signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04062Chemokine signaling pathway
hsa04910Insulin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04929GnRH secretion
hsa04915Estrogen signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04917Prolactin signaling pathway
hsa04926Relaxin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04973Carbohydrate digestion and absorption
hsa04960Aldosterone-regulated sodium reabsorption
hsa04725Cholinergic synapse
hsa04722Neurotrophin signaling pathway
hsa04750Inflammatory mediator regulation of TRP channels
hsa04360Axon guidance
hsa04380Osteoclast differentiation
hsa04211Longevity regulating pathway
hsa04213Longevity regulating pathway - multiple species
hsa05200Pathways in cancer
hsa05206MicroRNAs in cancer
hsa05205Proteoglycans in cancer
hsa05203Viral carcinogenesis
hsa05230Central carbon metabolism in cancer
hsa05231Choline metabolism in cancer
hsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05225Hepatocellular carcinoma
hsa05226Gastric cancer
hsa05214Glioma
hsa05221Acute myeloid leukemia
hsa05220Chronic myeloid leukemia
hsa05218Melanoma
hsa05211Renal cell carcinoma
hsa05215Prostate cancer
hsa05213Endometrial cancer
hsa05224Breast cancer
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
hsa05418Fluid shear stress and atherosclerosis
hsa04930Type II diabetes mellitus
hsa04932Non-alcoholic fatty liver disease
hsa04931Insulin resistance
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05135Yersinia infection
hsa05100Bacterial invasion of epithelial cells
hsa05166Human T-cell leukemia virus 1 infection
hsa05170Human immunodeficiency virus 1 infection
hsa05162Measles
hsa05164Influenza A
hsa05161Hepatitis B
hsa05160Hepatitis C
hsa05168Herpes simplex virus 1 infection
hsa05163Human cytomegalovirus infection
hsa05167Kaposi sarcoma-associated herpesvirus infection
hsa05169Epstein-Barr virus infection
hsa05165Human papillomavirus infection
hsa05146Amoebiasis
hsa05142Chagas disease
hsa01521EGFR tyrosine kinase inhibitor resistance
hsa01524Platinum drug resistance
hsa01522Endocrine resistance
hsa01100Metabolic pathways
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
hsa04915Estrogen signaling pathway
hsa05166Human T-cell leukemia virus 1 infection
hsa05203Viral carcinogenesis
hsa04024cAMP signaling pathway
hsa05163Human cytomegalovirus infection
hsa04750Inflammatory mediator regulation of TRP channels
hsa04725Cholinergic synapse
hsa04218Cellular senescence
hsa04810Regulation of actin cytoskeleton
hsa05206MicroRNAs in cancer
hsa04015Rap1 signaling pathway
hsa04152AMPK signaling pathway
hsa05165Human papillomavirus infection
hsa04935Growth hormone synthesis, secretion and action
hsa04066HIF-1 signaling pathway
hsa04211Longevity regulating pathway
hsa04910Insulin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04071Sphingolipid signaling pathway
hsa05131Shigellosis
hsa04072Phospholipase D signaling pathway
hsa04931Insulin resistance
hsa04611Platelet activation
hsa04014Ras signaling pathway
hsa05418Fluid shear stress and atherosclerosis
hsa05225Hepatocellular carcinoma
hsa05205Proteoglycans in cancer
hsa05170Human immunodeficiency virus 1 infection
hsa04926Relaxin signaling pathway
hsa04932Non-alcoholic fatty liver disease
hsa05223Non-small cell lung cancer
hsa04140Autophagy - animal
hsa05168Herpes simplex virus 1 infection
hsa04150mTOR signaling pathway
hsa05161Hepatitis B
hsa04070Phosphatidylinositol signaling system
hsa04510Focal adhesion
hsa04666Fc gamma R-mediated phagocytosis
hsa05214Glioma
hsa04062Chemokine signaling pathway
hsa05167Kaposi sarcoma-associated herpesvirus infection
hsa05146Amoebiasis
hsa04068FoxO signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa05226Gastric cancer
hsa05215Prostate cancer
hsa04213Longevity regulating pathway - multiple species
hsa05230Central carbon metabolism in cancer
hsa05222Small cell lung cancer
hsa04360Axon guidance
hsa05160Hepatitis C
hsa05169Epstein-Barr virus infection
hsa01522Endocrine resistance
hsa04929GnRH secretion
hsa04914Progesterone-mediated oocyte maturation
hsa05135Yersinia infection
hsa01521EGFR tyrosine kinase inhibitor resistance
hsa04625C-type lectin receptor signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa05212Pancreatic cancer
hsa04670Leukocyte transendothelial migration
hsa04370VEGF signaling pathway
hsa05210Colorectal cancer
hsa05142Chagas disease
hsa04668TNF signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04012ErbB signaling pathway
hsa00562Inositol phosphate metabolism
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04973Carbohydrate digestion and absorption
hsa05224Breast cancer
hsa05100Bacterial invasion of epithelial cells
hsa05231Choline metabolism in cancer
hsa05211Renal cell carcinoma
hsa04210Apoptosis
hsa05218Melanoma
hsa04664Fc epsilon RI signaling pathway
hsa04917Prolactin signaling pathway
hsa04660T cell receptor signaling pathway
hsa05162Measles
hsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05164Influenza A
hsa05220Chronic myeloid leukemia
hsa04930Type II diabetes mellitus
hsa04960Aldosterone-regulated sodium reabsorption
hsa05213Endometrial cancer
hsa05221Acute myeloid leukemia
hsa04630JAK-STAT signaling pathway
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa01524Platinum drug resistance
hsa04662B cell receptor signaling pathway
Associated diseases References
Cancer (breast) GAD: 20508983
Cancer (esophageal) GAD: 16380997
Hypercholesterolemia GAD: 20602615
Insulin resistance GAD: 17977952
Diabetes GAD: 11016459
Schizophrenia GAD: 20691427
Spermatogenesis defects MIK: 26132308
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Role in spermatogenesis MIK: 26132308
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
26132308 Role in sp
ermatogene
sis


Male infertility
Show abstract
17327269 Teratozoos
permia

13 (5 controls,
8 cases)
Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm

18
Male infertility GSE26881
Show abstract