Male Infertility Database

Search Result

Gene id

5290

Gene Summary SNPs Protein Summary Gene ontology KEGG pathways Diseases PubMed

Gene Summary

Gene Symbol

PIK3CA Gene UCSC Ensembl

Aliases

CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha

Gene name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

Alternate names

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, PI3-kinase p110 subunit alpha, phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide, phosphatidylinositol-4,5-b,

Gene location

3q26.32 (179148113: 179240092) Exons: 23 NC_000003.12

Gene summary(Entrez)

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has

OMIM

171834

SNPs

rs397515395

Strand:    Allele origin:   Allele change:   Mutation type: delins

NC_000019.10   g.55161685dup
NC_000019.9   g.55673053dup
NG_007866.2   g.1048dup
NG_032759.1   g.10038dup
NM_178837.4   c.762dup
NM_001256715.2   c.621dup
NM_001256715.1   c.621dup
NM_001256716.1   c.459dup
NM_001256714.1   c.825dup
NP_849159.2   p.Val255fs
NP_001243644

rs387907152

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000019.10   g.55165427G>A
NC_000019.9   g.55676795G>A
NG_032759.1   g.6296C>T
NM_178837.4   c.406C>T
NM_001256715.2   c.265C>T
NM_001256715.1   c.265C>T
NM_001256716.1   c.103C>T
NM_001256714.1   c.469C>T
NP_849159.2   p.Arg136Ter
NP_001243644.1   p.Arg89Ter
NP_00124

rs387907151

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000019.10   g.55165904A>G
NC_000019.9   g.55677272A>G
NG_032759.1   g.5819T>C
NM_178837.4   c.323T>C
NM_001256715.2   c.182T>C
NM_001256715.1   c.182T>C
NM_001256716.1   c.-57T>C
NM_001256714.1   c.386T>C
NP_849159.2   p.Leu108Pro
NP_001243644.1   p.Leu61Pro
NP_00124

Protein Summary

Protein general information

P42336

Name: Phosphatidylinositol 4,5 bisphosphate 3 kinase catalytic subunit alpha isoform (PI3 kinase subunit alpha) (PI3K alpha) (PI3Kalpha) (PtdIns 3 kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alp

Length: 1068 Mass: 124,284

Sequence

MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQ
EAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEA
VDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAI
RKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQR
VPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPH
GLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRE
NDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEM
HNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQG
FLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQ
NQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTR
EFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGG
WTTKMDWIFHTIKQHALN

Structural information

Protein Domains	PI3K-ABD. (16-105) PI3K-RBD. (187-289) C2 (330-487) PIK (517-694)
Interpro:	IPR016024 IPR011009 IPR000403 IPR036940 IPR018936 IPR003113 IPR002420 IPR000341 IPR008290 IPR037704 IPR015433 IPR001263 IPR029071
Prosite:	PS00915 PS00916 PS50290 PS51544 PS51547 PS51546 PS51545
CDD:	cd05175
PDB:	2ENQ 2RD0 3HHM 3HIZ 3ZIM 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4TUU 4TV3 4WAF 4YKN 4ZOP 5DXH 5DXT 5FI4 5ITD 5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK 5UBR 5UK8 5UKJ 5UL1
PDBsum:	2ENQ 2RD0 3HHM 3HIZ 3ZIM 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4TUU 4TV3 4WAF 4YKN 4ZOP 5DXH 5DXT 5FI4 5ITD 5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK 5UBR 5UK8 5UKJ 5UL1
DIP:	42728
MINT:
STRING:	ENSP00000263967

Other Databases

GeneCards: PIK3CA Malacards: PIK3CA

Gene ontology

Expand All | Collapse All

GO accession	Term name	Evidence code	Go category
GO:0001525	angiogenesis	IEA	biological process
GO:0001889	liver development	IEA	biological process
GO:0001944	vasculature development	TAS	biological process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005886	plasma membrane	IBA	cellular component
GO:0005942	phosphatidylinositol 3-ki nase complex	ISS	cellular component
GO:0005943	phosphatidylinositol 3-ki nase complex, class IA	IDA	cellular component
GO:0006006	glucose metabolic process	IEA	biological process
GO:0006468	protein phosphorylation	IEA	biological process
GO:0006661	phosphatidylinositol bios ynthetic process	TAS	biological process
GO:0007173	epidermal growth factor r eceptor signaling pathway	TAS	biological process
GO:0010468	regulation of gene expres sion	IEA	biological process
GO:0014066	regulation of phosphatidy linositol 3-kinase signal ing	TAS	biological process
GO:0016301	kinase activity	TAS	molecular function
GO:0016301	kinase activity	TAS	molecular function
GO:0016301	kinase activity	TAS	molecular function
GO:0016301	kinase activity	TAS	molecular function
GO:0016301	kinase activity	TAS	molecular function
GO:0016303	1-phosphatidylinositol-3- kinase activity	IDA	molecular function
GO:0016303	1-phosphatidylinositol-3- kinase activity	TAS	molecular function
GO:0030027	lamellipodium	IEA	cellular component
GO:0030168	platelet activation	TAS	biological process
GO:0030168	platelet activation	TAS	biological process
GO:0030295	protein kinase activator activity	IEA	molecular function
GO:0031295	T cell costimulation	TAS	biological process
GO:0031295	T cell costimulation	TAS	biological process
GO:0032147	activation of protein kin ase activity	IEA	biological process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IEA	biological process
GO:0035004	phosphatidylinositol 3-ki nase activity	ISS	molecular function
GO:0035004	phosphatidylinositol 3-ki nase activity	TAS	molecular function
GO:0035005	1-phosphatidylinositol-4- phosphate 3-kinase activi ty	IBA	molecular function
GO:0036092	phosphatidylinositol-3-ph osphate biosynthetic proc ess	IEA	biological process
GO:0038028	insulin receptor signalin g pathway via phosphatidy linositol 3-kinase	TAS	biological process
GO:0038095	Fc-epsilon receptor signa ling pathway	TAS	biological process
GO:0038096	Fc-gamma receptor signali ng pathway involved in ph agocytosis	TAS	biological process
GO:0038128	ERBB2 signaling pathway	TAS	biological process
GO:0040014	regulation of multicellul ar organism growth	IEA	biological process
GO:0043457	regulation of cellular re spiration	IEA	biological process
GO:0043491	protein kinase B signalin g	IEA	biological process
GO:0043524	negative regulation of ne uron apoptotic process	IEA	biological process
GO:0043542	endothelial cell migratio n	TAS	biological process
GO:0043560	insulin receptor substrat e binding	IEA	molecular function
GO:0044029	hypomethylation of CpG is land	IEA	biological process
GO:0046854	phosphatidylinositol phos phorylation	ISS	biological process
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	IBA	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0048010	vascular endothelial grow th factor receptor signal ing pathway	TAS	biological process
GO:0048015	phosphatidylinositol-medi ated signaling	TAS	biological process
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0050900	leukocyte migration	TAS	biological process
GO:0060048	cardiac muscle contractio n	TAS	biological process
GO:0060612	adipose tissue developmen t	IEA	biological process
GO:0071333	cellular response to gluc ose stimulus	IEA	biological process
GO:0097009	energy homeostasis	IEA	biological process
GO:0098779	mitophagy in response to mitochondrial depolarizat ion	IGI	biological process
GO:2000270	negative regulation of fi broblast apoptotic proces s	IEA	biological process
GO:2000653	regulation of genetic imp rinting	IEA	biological process
GO:2000811	negative regulation of an oikis	IMP	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0001525	angiogenesis	IEA	biological process
GO:0001889	liver development	IEA	biological process
GO:0001944	vasculature development	TAS	biological process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005622	intracellular	IEA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005886	plasma membrane	IBA	cellular component
GO:0005942	phosphatidylinositol 3-ki nase complex	IEA	cellular component
GO:0005942	phosphatidylinositol 3-ki nase complex	ISS	cellular component
GO:0005943	phosphatidylinositol 3-ki nase complex, class IA	IDA	cellular component
GO:0006006	glucose metabolic process	IEA	biological process
GO:0006468	protein phosphorylation	IEA	biological process
GO:0006661	phosphatidylinositol bios ynthetic process	TAS	biological process
GO:0006909	phagocytosis	IEA	biological process
GO:0007173	epidermal growth factor r eceptor signaling pathway	TAS	biological process
GO:0010468	regulation of gene expres sion	IEA	biological process
GO:0014066	regulation of phosphatidy linositol 3-kinase signal ing	TAS	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0016301	kinase activity	TAS	molecular function
GO:0016301	kinase activity	TAS	molecular function
GO:0016301	kinase activity	TAS	molecular function
GO:0016301	kinase activity	TAS	molecular function
GO:0016301	kinase activity	TAS	molecular function
GO:0016303	1-phosphatidylinositol-3- kinase activity	IEA	molecular function
GO:0016303	1-phosphatidylinositol-3- kinase activity	IDA	molecular function
GO:0016303	1-phosphatidylinositol-3- kinase activity	TAS	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0030027	lamellipodium	IEA	cellular component
GO:0030168	platelet activation	TAS	biological process
GO:0030168	platelet activation	TAS	biological process
GO:0030295	protein kinase activator activity	IEA	molecular function
GO:0031295	T cell costimulation	TAS	biological process
GO:0031295	T cell costimulation	TAS	biological process
GO:0032147	activation of protein kin ase activity	IEA	biological process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IEA	biological process
GO:0035004	phosphatidylinositol 3-ki nase activity	ISS	molecular function
GO:0035004	phosphatidylinositol 3-ki nase activity	TAS	molecular function
GO:0035005	1-phosphatidylinositol-4- phosphate 3-kinase activi ty	IBA	molecular function
GO:0036092	phosphatidylinositol-3-ph osphate biosynthetic proc ess	IEA	biological process
GO:0038028	insulin receptor signalin g pathway via phosphatidy linositol 3-kinase	TAS	biological process
GO:0038095	Fc-epsilon receptor signa ling pathway	TAS	biological process
GO:0038096	Fc-gamma receptor signali ng pathway involved in ph agocytosis	TAS	biological process
GO:0038128	ERBB2 signaling pathway	TAS	biological process
GO:0040014	regulation of multicellul ar organism growth	IEA	biological process
GO:0043457	regulation of cellular re spiration	IEA	biological process
GO:0043491	protein kinase B signalin g	IEA	biological process
GO:0043524	negative regulation of ne uron apoptotic process	IEA	biological process
GO:0043542	endothelial cell migratio n	TAS	biological process
GO:0043560	insulin receptor substrat e binding	IEA	molecular function
GO:0044029	hypomethylation of CpG is land	IEA	biological process
GO:0046854	phosphatidylinositol phos phorylation	IEA	biological process
GO:0046854	phosphatidylinositol phos phorylation	ISS	biological process
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	IEA	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	IBA	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0048010	vascular endothelial grow th factor receptor signal ing pathway	TAS	biological process
GO:0048015	phosphatidylinositol-medi ated signaling	IEA	biological process
GO:0048015	phosphatidylinositol-medi ated signaling	TAS	biological process
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0050900	leukocyte migration	TAS	biological process
GO:0060048	cardiac muscle contractio n	TAS	biological process
GO:0060612	adipose tissue developmen t	IEA	biological process
GO:0071333	cellular response to gluc ose stimulus	IEA	biological process
GO:0097009	energy homeostasis	IEA	biological process
GO:0098779	mitophagy in response to mitochondrial depolarizat ion	IGI	biological process
GO:2000270	negative regulation of fi broblast apoptotic proces s	IEA	biological process
GO:2000653	regulation of genetic imp rinting	IEA	biological process
GO:2000811	negative regulation of an oikis	IMP	biological process
GO:0001944	vasculature development	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005886	plasma membrane	IBA	cellular component
GO:0005942	phosphatidylinositol 3-ki nase complex	ISS	cellular component
GO:0005943	phosphatidylinositol 3-ki nase complex, class IA	IDA	cellular component
GO:0006661	phosphatidylinositol bios ynthetic process	TAS	biological process
GO:0007173	epidermal growth factor r eceptor signaling pathway	TAS	biological process
GO:0014066	regulation of phosphatidy linositol 3-kinase signal ing	TAS	biological process
GO:0016301	kinase activity	TAS	molecular function
GO:0016301	kinase activity	TAS	molecular function
GO:0016301	kinase activity	TAS	molecular function
GO:0016301	kinase activity	TAS	molecular function
GO:0016301	kinase activity	TAS	molecular function
GO:0016303	1-phosphatidylinositol-3- kinase activity	IDA	molecular function
GO:0016303	1-phosphatidylinositol-3- kinase activity	TAS	molecular function
GO:0030168	platelet activation	TAS	biological process
GO:0030168	platelet activation	TAS	biological process
GO:0031295	T cell costimulation	TAS	biological process
GO:0031295	T cell costimulation	TAS	biological process
GO:0035004	phosphatidylinositol 3-ki nase activity	ISS	molecular function
GO:0035004	phosphatidylinositol 3-ki nase activity	TAS	molecular function
GO:0035005	1-phosphatidylinositol-4- phosphate 3-kinase activi ty	IBA	molecular function
GO:0038028	insulin receptor signalin g pathway via phosphatidy linositol 3-kinase	TAS	biological process
GO:0038095	Fc-epsilon receptor signa ling pathway	TAS	biological process
GO:0038096	Fc-gamma receptor signali ng pathway involved in ph agocytosis	TAS	biological process
GO:0038128	ERBB2 signaling pathway	TAS	biological process
GO:0043542	endothelial cell migratio n	TAS	biological process
GO:0046854	phosphatidylinositol phos phorylation	ISS	biological process
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	IBA	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular function
GO:0048010	vascular endothelial grow th factor receptor signal ing pathway	TAS	biological process
GO:0048015	phosphatidylinositol-medi ated signaling	TAS	biological process
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0050900	leukocyte migration	TAS	biological process
GO:0060048	cardiac muscle contractio n	TAS	biological process
GO:0098779	mitophagy in response to mitochondrial depolarizat ion	IGI	biological process
GO:2000811	negative regulation of an oikis	IMP	biological process

KEGG pathways

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Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00010	Glycolysis / Gluconeogenesis
hsa00020	Citrate cycle
hsa00051	Fructose and mannose metabolism
hsa00520	Amino sugar and nucleotide sugar metabolism
hsa00630	Glyoxylate and dicarboxylate metabolism
hsa00562	Inositol phosphate metabolism
hsa00190	Oxidative phosphorylation
hsa00190	Oxidative phosphorylation
hsa00190	Oxidative phosphorylation
hsa00190	Oxidative phosphorylation
hsa00190	Oxidative phosphorylation
hsa00100	Steroid biosynthesis
hsa00140	Steroid hormone biosynthesis
hsa00140	Steroid hormone biosynthesis
hsa00564	Glycerophospholipid metabolism
hsa00564	Glycerophospholipid metabolism
hsa00230	Purine metabolism
hsa00240	Pyrimidine metabolism
hsa00270	Cysteine and methionine metabolism
hsa00280	Valine, leucine and isoleucine degradation
hsa00330	Arginine and proline metabolism
hsa00340	Histidine metabolism
hsa00380	Tryptophan metabolism
hsa00480	Glutathione metabolism
hsa00480	Glutathione metabolism
hsa00513	Various types of N-glycan biosynthesis
hsa00511	Other glycan degradation
hsa00830	Retinol metabolism
hsa00860	Porphyrin and chlorophyll metabolism
hsa00900	Terpenoid backbone biosynthesis
hsa00232	Caffeine metabolism
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa00982	Drug metabolism - cytochrome P450
hsa00982	Drug metabolism - cytochrome P450
hsa00983	Drug metabolism - other enzymes
hsa03022	Basal transcription factors
hsa03040	Spliceosome
hsa03040	Spliceosome
hsa03013	RNA transport
hsa03013	RNA transport
hsa03008	Ribosome biogenesis in eukaryotes
hsa03008	Ribosome biogenesis in eukaryotes
hsa04141	Protein processing in endoplasmic reticulum
hsa04141	Protein processing in endoplasmic reticulum
hsa04141	Protein processing in endoplasmic reticulum
hsa04141	Protein processing in endoplasmic reticulum
hsa04141	Protein processing in endoplasmic reticulum
hsa04141	Protein processing in endoplasmic reticulum
hsa04130	SNARE interactions in vesicular transport
hsa04120	Ubiquitin mediated proteolysis
hsa03018	RNA degradation
hsa03410	Base excision repair
hsa03420	Nucleotide excision repair
hsa03430	Mismatch repair
hsa03440	Homologous recombination
hsa03440	Homologous recombination
hsa03460	Fanconi anemia pathway
hsa03460	Fanconi anemia pathway
hsa04014	Ras signaling pathway
hsa04014	Ras signaling pathway
hsa04014	Ras signaling pathway
hsa04014	Ras signaling pathway
hsa04014	Ras signaling pathway
hsa04014	Ras signaling pathway
hsa04014	Ras signaling pathway
hsa04014	Ras signaling pathway
hsa04014	Ras signaling pathway
hsa04015	Rap1 signaling pathway
hsa04015	Rap1 signaling pathway
hsa04015	Rap1 signaling pathway
hsa04010	MAPK signaling pathway
hsa04010	MAPK signaling pathway
hsa04010	MAPK signaling pathway
hsa04012	ErbB signaling pathway
hsa04012	ErbB signaling pathway
hsa04310	Wnt signaling pathway
hsa04330	Notch signaling pathway
hsa04350	TGF-beta signaling pathway
hsa04350	TGF-beta signaling pathway
hsa04350	TGF-beta signaling pathway
hsa04390	Hippo signaling pathway
hsa04390	Hippo signaling pathway
hsa04390	Hippo signaling pathway
hsa04370	VEGF signaling pathway
hsa04370	VEGF signaling pathway
hsa04371	Apelin signaling pathway
hsa04630	JAK-STAT signaling pathway
hsa04630	JAK-STAT signaling pathway
hsa04630	JAK-STAT signaling pathway
hsa04630	JAK-STAT signaling pathway
hsa04630	JAK-STAT signaling pathway
hsa04064	NF-kappa B signaling pathway
hsa04064	NF-kappa B signaling pathway
hsa04668	TNF signaling pathway
hsa04066	HIF-1 signaling pathway
hsa04068	FoxO signaling pathway
hsa04070	Phosphatidylinositol signaling system
hsa04072	Phospholipase D signaling pathway
hsa04071	Sphingolipid signaling pathway
hsa04024	cAMP signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04152	AMPK signaling pathway
hsa04150	mTOR signaling pathway
hsa04140	Autophagy - animal
hsa04210	Apoptosis
hsa04218	Cellular senescence
hsa04510	Focal adhesion
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa04810	Regulation of actin cytoskeleton
hsa04611	Platelet activation
hsa04620	Toll-like receptor signaling pathway
hsa04625	C-type lectin receptor signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa04670	Leukocyte transendothelial migration
hsa04062	Chemokine signaling pathway
hsa04910	Insulin signaling pathway
hsa04923	Regulation of lipolysis in adipocytes
hsa04929	GnRH secretion
hsa04915	Estrogen signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa04917	Prolactin signaling pathway
hsa04926	Relaxin signaling pathway
hsa04919	Thyroid hormone signaling pathway
hsa04973	Carbohydrate digestion and absorption
hsa04960	Aldosterone-regulated sodium reabsorption
hsa04725	Cholinergic synapse
hsa04722	Neurotrophin signaling pathway
hsa04750	Inflammatory mediator regulation of TRP channels
hsa04360	Axon guidance
hsa04380	Osteoclast differentiation
hsa04211	Longevity regulating pathway
hsa04213	Longevity regulating pathway - multiple species
hsa05200	Pathways in cancer
hsa05206	MicroRNAs in cancer
hsa05205	Proteoglycans in cancer
hsa05203	Viral carcinogenesis
hsa05230	Central carbon metabolism in cancer
hsa05231	Choline metabolism in cancer
hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05210	Colorectal cancer
hsa05212	Pancreatic cancer
hsa05225	Hepatocellular carcinoma
hsa05226	Gastric cancer
hsa05214	Glioma
hsa05221	Acute myeloid leukemia
hsa05220	Chronic myeloid leukemia
hsa05218	Melanoma
hsa05211	Renal cell carcinoma
hsa05215	Prostate cancer
hsa05213	Endometrial cancer
hsa05224	Breast cancer
hsa05222	Small cell lung cancer
hsa05223	Non-small cell lung cancer
hsa05418	Fluid shear stress and atherosclerosis
hsa04930	Type II diabetes mellitus
hsa04932	Non-alcoholic fatty liver disease
hsa04931	Insulin resistance
hsa04933	AGE-RAGE signaling pathway in diabetic complications
hsa05135	Yersinia infection
hsa05100	Bacterial invasion of epithelial cells
hsa05166	Human T-cell leukemia virus 1 infection
hsa05170	Human immunodeficiency virus 1 infection
hsa05162	Measles
hsa05164	Influenza A
hsa05161	Hepatitis B
hsa05160	Hepatitis C
hsa05168	Herpes simplex virus 1 infection
hsa05163	Human cytomegalovirus infection
hsa05167	Kaposi sarcoma-associated herpesvirus infection
hsa05169	Epstein-Barr virus infection
hsa05165	Human papillomavirus infection
hsa05146	Amoebiasis
hsa05142	Chagas disease
hsa01521	EGFR tyrosine kinase inhibitor resistance
hsa01524	Platinum drug resistance
hsa01522	Endocrine resistance

Diseases

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Associated diseases	References
Astrocytoma	GAD: 20569675
Cancer	GAD: 19903786
Cancer (Adenocarcinoma)	GAD: 19861897
Cancer (Adenoma)	GAD: 19440799
Cancer (colon)	GAD: 19237633
Cancer (colorectal)	GAD: 15994075
Cancer (cystadenocarcinoma)	GAD: 20495538
Cancer (endometrial)	GAD: 17471559
Cancer (epithelial ovarian)	GAD: 19064572
Cancer (esophageal)	GAD: 16380997
Cancer (lung)	GAD: 17487277
Cancer (nasopharyngeal)	GAD: 19012001
Cancer (ovarian)	GAD: 18794094
Cancer (Pancreatic ductal)	GAD: 19818761
Cancer (hepatocellular)	GAD: 171834
Cancer (pancreatic)	GAD: 19351817
Cancer (Papilary)	GAD: 19487299
Cancer (prostate)	GAD: 20407443
Cancer (breast)	GAD: 16353168
Cancer (ovarian)	KEGG: H00027
Cancer (Non-small cell lung)	OMIM: 171834
Cancer (gastric)	OMIM: 171834
Cancer (rectal)	GAD: 19903786
Cancer (retinal)	GAD: 19420344
Cancer (Squamous cell)	GAD: 20813562
Cancer (stomach)	GAD: 20398348
Cancer (thyroid)	GAD: 15928251
Cowden syndrome	OMIM: 171834
Diabetes	GAD: 20416077
Hypercholesterolemia	GAD: 20602615
Alzheimer's disease	GAD: 19141999
Schizophrenia	GAD: 20691427
Endometriosis	INFBASE: 20493625
Polycystic ovary syndrome (PCOS)	INFBASE: 17083810
Male factor infertility	MIK: 23634797
Varicocele	MIK: 23634797
Varicocele	MIK: 23634797
Keratosis	OMIM: 171834
Megalencephaly-capillary malformation-polymicrogyria syndrome	OMIM: 171834
CLOVE syndrome	OMIM: 171834
Associated with development and maintenance of sperm motility, asthenozoospermia	MIK: 11527900
Male factor infertility	MIK: 23634797
Varicocele	MIK: 23634797

PubMed references

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PMID	Condition	Infertility_type	Abstract
23634797	Varicocele	Male infertility	Show abstract
23634797	Male facto r infertil ity, varic ocele	Male infertility	Show abstract
11527900	Associated with deve lopment an d maintena nce of spe rm motilit y, astheno zoospermia	Male infertility	Show abstract

Male Infertility knowledgebase

A repository with genes crucial for male fertility

Search Result

Gene Summary

SNPs

Protein Summary

Gene ontology

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KEGG pathways

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Diseases

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PubMed references

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Male Infertility knowledgebase

A repository with genes crucial for male fertility

Search Result

Gene Summary

SNPs

Protein Summary

Gene ontology

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KEGG pathways Expand All | Collapse All

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Diseases Expand All | Collapse All

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PubMed references

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KEGG pathways

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Diseases

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