• Gene id: 5260

Gene Summary

• Gene Symbol: PHKG1   Gene   UCSC   Ensembl
• Aliases: PHKG
• Gene name: phosphorylase kinase catalytic subunit gamma 1
• Alternate names: phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform, PHK-gamma-M, phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform, phosphorylase kinase gamma subunit 1, phosphorylase kinase subunit gamma-1, phosphorylase kinase, g,
• Gene location: 7p11.2 (56093449: 56079926)     Exons: 13     NC_000007.14
• Gene summary(Entrez): This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios

Protein Summary

• Protein general information: Q16816  
  • Name: Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK gamma M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1) (Serine/threonine protein kinase PHKG1) (EC 2.7.11.1) (EC 2.7.11.26)
  • Length: 387  
  • Mass: 45024
• Sequence:

  MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV
  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRD
  LKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA
  GSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFS
  PRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTP
  KAVLLSLAEEDY

• Structural information:
  • Protein Domains: (20..28-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR011009  IPR002291  IPR000719  IPR017441  IPR008271  
  • Prosite: PS00107 PS50011 PS00108
  • STRING: ENSP00000445440
• Other Databases: GeneCards:  PHKG1  Malacards:  PHKG1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004689	phosphorylase kinase activity	IEA	molecular function
GO:0005516	calmodulin binding	IEA	molecular function
GO:0005978	glycogen biosynthetic process	IEA	biological process
GO:0004672	protein kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005964	phosphorylase kinase complex	IEA	cellular component
GO:0006468	protein phosphorylation	IEA	biological process
GO:0005516	calmodulin binding	IEA	molecular function
GO:0005977	glycogen metabolic process	IEA	biological process
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0005975	carbohydrate metabolic process	NAS	biological process
GO:0004689	phosphorylase kinase activity	IEA	molecular function
GO:0050321	tau-protein kinase activity	IEA	molecular function
GO:0005980	glycogen catabolic process	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0004689	phosphorylase kinase activity	IEA	molecular function
GO:0005977	glycogen metabolic process	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0005964	phosphorylase kinase complex	IEA	cellular component
GO:0006468	protein phosphorylation	IEA	biological process
GO:0019899	enzyme binding	IEA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04020	Calcium signaling pathway
hsa04910	Insulin signaling pathway
hsa04922	Glucagon signaling pathway

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881