|
Gene id |
5245 |
| Gene Summary Protein Summary Gene ontology Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
PHB Gene UCSC Ensembl |
|
Aliases |
HEL-215, HEL-S-54e, PHB1 |
|
Gene name |
prohibitin |
|
Alternate names |
prohibitin, epididymis luminal protein 215, epididymis secretory sperm binding protein Li 54e, |
|
Gene location |
17q21.33 (49414904: 49404047) Exons: 8 NC_000011.10
|
|
Gene summary(Entrez) |
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting reg
|
|
OMIM |
176705 |
Protein Summary
|
|
| GO accession | Term name | Evidence code | Go category |
|---|
|
|
| Associated diseases |
References |
| Cancer (bladder) | GAD: 19692168 |
| Cancer (breast) | GAD: 11377649 |
| Cancer (lung) | GAD: 18676680 |
| Cancer (ovarian) | GAD: 12821355 |
| Bipolar disorder | GAD: 19416921 |
| Oligoasthenozoospermia | MIK: 22324369 |
| Ubiquitination of this protein facilitates marking of defective spermatozoa in the epididymis for degradation | MIK: 12646488 |
| Asthenozoospermia | MIK: 22324369 |
| Chronic obstructive pulmonary disease (COPD) | GAD: 19625176 |
| Asthenospermia | MIK: 22324369 |
| Oligoasthenospermia | MIK: 22324369 |
| Teratozoospermia | MIK: 17327269 |
| Ubiquitination of this protein facilitates marking of defective spermatozoa in the epididymis for degradation | MIK: 12646488 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 12646488 |
Ubiquitina
tion of th
is protein
facilitat
es marking
of defect
ive sperma
tozoa in t
he epididy
mis for de
gradation
|
|
|
|
Male infertility |
|
Show abstract |
| 22324369 |
Asthenospe
rmia, olig
oasthenosp
ermia
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
13 (5 controls,
8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
|