• Gene id: 5212

Gene Summary

• Gene Symbol: VIT   Gene   UCSC   Ensembl
• Aliases: VIT1
• Gene name: vitrin
• Alternate names: vitrin,
• Gene location: 2p22.2 (36696689: 36814793)     Exons: 18     NC_000002.12
• Gene summary(Entrez): This gene encodes an extracellular matrix (ECM) protein. The protein may be associated with cell adhesion and migration. High levels of expression of the protein in specific parts of the brain suggest its likely role in neural development. [provided by Re
• OMIM: 108745

Protein Summary

• Protein general information: Q6UXI7  
  • Name: Vitrin
  • Length: 678  
  • Mass: 73930
• Sequence:

  MRTVVLTMKASVIEMFLVLLVTGVHSNKETAKKIKRPKFTVPQINCDVKAGKIIDPEFIVKCPAGCQDPKYHVYG
  TDVYASYSSVCGAAVHSGVLDNSGGKILVRKVAGQSGYKGSYSNGVQSLSLPRWRESFIVLESKPKKGVTYPSAL
  TYSSSKSPAAQAGETTKAYQRPPIPGTTAQPVTLMQLLAVTVAVATPTTLPRPSPSAASTTSIPRPQSVGHRSQE
  MDLWSTATYTSSQNRPRADPGIQRQDPSGAAFQKPVGADVSLGLVPKEELSTQSLEPVSLGDPNCKIDLSFLIDG
  STSIGKRRFRIQKQLLADVAQALDIGPAGPLMGVVQYGDNPATHFNLKTHTNSRDLKTAIEKITQRGGLSNVGRA
  ISFVTKNFFSKANGNRSGAPNVVVVMVDGWPTDKVEEASRLARESGINIFFITIEGAAENEKQYVVEPNFANKAV
  CRTNGFYSLHVQSWFGLHKTLQPLVKRVCDTDRLACSKTCLNSADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEF
  EISDTDTRIGAVQYTYEQRLEFGFDKYSSKPDILNAIKRVGYWSGGTSTGAAINFALEQLFKKSKPNKRKLMILI
  TDGRSYDDVRIPAMAAHLKGVITYAIGVAWAAQEELEVIATHPARDHSFFVDEFDNLHQYVPRIIQNICTEFNSQ
  PRN

• Structural information:
  • Protein Domains: (40..13-)
    (/note="LCCL-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00123-)
    (293..47-)
    (/note="VWFA-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00219-)
    (495..66-)
    (/note="VWFA-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00219"-)
  • Interpro: IPR004043  IPR036609  IPR002035  IPR036465  
  • Prosite: PS50820 PS50234
  • STRING: ENSP00000368544
• Other Databases: GeneCards:  VIT  Malacards:  VIT

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0062023	collagen-containing extracellular matrix	IBA	cellular component
GO:0010811	positive regulation of cell-substrate adhesion	IBA	biological process
GO:0005615	extracellular space	IBA	cellular component
GO:0030198	extracellular matrix organization	IBA	biological process
GO:0005614	interstitial matrix	IBA	cellular component
GO:0003429	growth plate cartilage chondrocyte morphogenesis	IBA	biological process
GO:0021510	spinal cord development	ISS	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0007399	nervous system development	IEA	biological process
GO:0010811	positive regulation of cell-substrate adhesion	IEA	biological process
GO:0021510	spinal cord development	IEA	biological process
GO:0031012	extracellular matrix	IEA	cellular component
GO:0005539	glycosaminoglycan binding	IEA	molecular function
GO:0005614	interstitial matrix	IEA	cellular component
GO:0030198	extracellular matrix organization	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq