• Gene id: 5173

Gene Summary

• Gene Symbol: PDYN   Gene   UCSC   Ensembl
• Aliases: ADCA, PENKB, SCA23
• Gene name: prodynorphin
• Alternate names: proenkephalin-B, beta-neoendorphin-dynorphin, leu-enkephalin, leumorphin, neoendorphin-dynorphin-enkephalin prepropeptide, preprodynorphin, preproenkephalin B, rimorphin,
• Gene location: 20p13 (1994284: 1978755)     Exons: 10     NC_000020.11
• Gene summary(Entrez): The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid rec
• OMIM: 613421

Protein Summary

• Protein general information: P01213  
  • Name: Proenkephalin B (Beta neoendorphin dynorphin) (Preprodynorphin) [Cleaved into: Alpha neoendorphin; Beta neoendorphin; Big dynorphin (Big Dyn); Dynorphin A(1 17) (Dyn A17) (Dynorphin A); Dynorphin A(1 13); Dynorphin A(1 8); Leu enkephalin; Rimorphin (Dynor
  • Length: 254  
  • Mass: 28385
• Sequence:

  MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFTPSTLG
  LNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQ
  LNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKR
  YGGFLRRQFKVVTRSQEDPNAYSGELFDA

• Structural information:
  • Interpro: IPR006024  IPR000750  
  • Prosite: PS01252
  • PDB: 2N2F
  • PDBsum: 2N2F
  • STRING: ENSP00000440185
• Other Databases: GeneCards:  PDYN  Malacards:  PDYN

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007218	neuropeptide signaling pathway	IBA	biological process
GO:0007268	chemical synaptic transmission	IBA	biological process
GO:0007600	sensory perception	IBA	biological process
GO:0030425	dendrite	IBA	cellular component
GO:0031628	opioid receptor binding	IBA	molecular function
GO:0005886	plasma membrane	IBA	cellular component
GO:0043025	neuronal cell body	IBA	cellular component
GO:0043679	axon terminus	IBA	cellular component
GO:0007218	neuropeptide signaling pathway	IEA	biological process
GO:0007218	neuropeptide signaling pathway	IEA	biological process
GO:0007268	chemical synaptic transmission	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0001515	opioid peptide activity	IEA	molecular function
GO:0007218	neuropeptide signaling pathway	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0007218	neuropeptide signaling pathway	IBA	biological process
GO:0007268	chemical synaptic transmission	IBA	biological process
GO:0007600	sensory perception	IBA	biological process
GO:0030425	dendrite	IBA	cellular component
GO:0031628	opioid receptor binding	IBA	molecular function
GO:0005886	plasma membrane	IBA	cellular component
GO:0043025	neuronal cell body	IBA	cellular component
GO:0043679	axon terminus	IBA	cellular component
GO:0007218	neuropeptide signaling pathway	IEA	biological process
GO:0007218	neuropeptide signaling pathway	IEA	biological process
GO:0007268	chemical synaptic transmission	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0001515	opioid peptide activity	IEA	molecular function
GO:0007218	neuropeptide signaling pathway	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04080	Neuroactive ligand-receptor interaction
hsa05034	Alcoholism
hsa05017	Spinocerebellar ataxia
hsa05031	Amphetamine addiction
hsa05030	Cocaine addiction

Diseases

Associated diseases	References
Spinocerebellar ataxia	KEGG:H00063
Spinocerebellar ataxia	KEGG:H00063
Temporal lobe epilepsy	PMID:11835385
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray