• Gene id: 51727

Gene Summary

• Gene Symbol: CMPK1   Gene   UCSC   Ensembl
• Aliases: CK, CMK, CMPK, UMK, UMP-CMPK, UMPK
• Gene name: cytidine/uridine monophosphate kinase 1
• Alternate names: UMP-CMP kinase, UMP/CMP kinase, cytidine monophosphate (UMP-CMP) kinase 1, cytosolic, cytidylate kinase, dCMP kinase, deoxycytidylate kinase, nucleoside-diphosphate kinase, uridine monophosphate kinase, uridine monophosphate/cytidine monophosphate kinase,
• Gene location: 1p33 (47333789: 47378838)     Exons: 7     NC_000001.11
• Gene summary(Entrez): This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in bo
• OMIM: 191710

Protein Summary

• Protein general information: P30085  
  • Name: UMP CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK)
  • Length: 196  
  • Mass: 22222
  • Tissue specificity: Ubiquitously expressed. {ECO
• Sequence:

  MKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEGKIVPVEITISLLKRE
  MDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICIERCLERGKSSGRSDDNRESLEK
  RIQTYLQSTKPIIDLYEEMGKVKKIDASKSVDEVFDEVVQIFDKEG

• Structural information:
  • Interpro: IPR000850  IPR033690  IPR027417  IPR006266  
  • Prosite: PS00113
  • CDD: cd01428
  • PDB: 1TEV
  • PDBsum: 1TEV
  • STRING: ENSP00000360939
• Other Databases: GeneCards:  CMPK1  Malacards:  CMPK1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004127	cytidylate kinase activity	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0006163	purine nucleotide metabolic process	IBA	biological process
GO:0006225	UDP biosynthetic process	IBA	biological process
GO:0033862	UMP kinase activity	IBA	molecular function
GO:0046705	CDP biosynthetic process	IBA	biological process
GO:0009041	uridylate kinase activity	IEA	molecular function
GO:0004127	cytidylate kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006139	nucleobase-containing compound metabolic process	IEA	biological process
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	IEA	biological process
GO:0006221	pyrimidine nucleotide biosynthetic process	IEA	biological process
GO:0019205	nucleobase-containing compound kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0006221	pyrimidine nucleotide biosynthetic process	IEA	biological process
GO:0016310	phosphorylation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0004849	uridine kinase activity	TAS	molecular function
GO:0005634	nucleus	TAS	cellular component
GO:0005737	cytoplasm	TAS	cellular component
GO:0009220	pyrimidine ribonucleotide biosynthetic process	TAS	biological process
GO:0004127	cytidylate kinase activity	IEA	molecular function
GO:0004550	nucleoside diphosphate kinase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0015949	nucleobase-containing small molecule interconversion	TAS	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0009041	uridylate kinase activity	IEA	molecular function
GO:0006221	pyrimidine nucleotide biosynthetic process	IEA	biological process
GO:0004127	cytidylate kinase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0046940	nucleoside monophosphate phosphorylation	IEA	biological process
GO:0046940	nucleoside monophosphate phosphorylation	IEA	biological process
GO:0046940	nucleoside monophosphate phosphorylation	IEA	biological process
GO:0046940	nucleoside monophosphate phosphorylation	IEA	biological process
GO:0046940	nucleoside monophosphate phosphorylation	IEA	biological process
GO:0006222	UMP biosynthetic process	IEA	biological process
GO:0006165	nucleoside diphosphate phosphorylation	IDA	biological process
GO:0009142	nucleoside triphosphate biosynthetic process	IDA	biological process
GO:0004550	nucleoside diphosphate kinase activity	IDA	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00983	Drug metabolism - other enzymes
hsa00240	Pyrimidine metabolism

Diseases

Associated diseases	References
lung non-small cell carcinoma	PMID:21642870
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq