• Gene id: 5170

Gene Summary

• Gene Symbol: PDPK1   Gene   UCSC   Ensembl
• Aliases: PDK1, PDPK2, PDPK2P, PRO0461
• Gene name: 3-phosphoinositide dependent protein kinase 1
• Alternate names: 3-phosphoinositide-dependent protein kinase 1, 3-phosphoinositide-dependent protein kinase 2 pseudogene, PkB kinase like gene 1,
• Gene location: 16p13.3 (2538013: 2603189)     Exons: 17     NC_000016.10
• OMIM: 602133

SNPs

rs3791185

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000001.11   g.107058247G>A
NC_000001.10   g.107600869G>A
NM_018137.2   c.*404G>A
NM_018137.3   c.*404G>A|SEQ=[G/A]|GENE=PRMT6

rs2232015

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000001.11   g.107056636A>G
NC_000001.11   g.107056636A>T
NC_000001.10   g.107599258A>G
NC_000001.10   g.107599258A>T|SEQ=[A/G/T]|GENE=PRMT6

Protein Summary

• Protein general information: O15530  
  • Name: 3 phosphoinositide dependent protein kinase 1 (hPDK1) (EC 2.7.11.1)
  • Length: 556  
  • Mass: 63152
  • Tissue specificity: Appears to be expressed ubiquitously. The Tyr-9 phosphorylated form is markedly increased in diseased tissue compared with normal tissue from lung, liver, colon and breast. {ECO
• Sequence:

  MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPR
  KKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQ
  DDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG
  TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYD
  FPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGN
  YDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQ
  FVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYL
  MDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ

• Structural information:
  • Protein Domains: (82..34-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159-)
    (459..55-)
    (/note="PH"-)
  • Interpro: IPR011009  IPR033931  IPR039046  IPR011993  IPR000719   IPR017441  IPR008271  
  • Prosite: PS00107 PS50011 PS00108
  • CDD: cd01262
  • PDB: 1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 2XCH 2XCK 3H9O 3HRC 3HRF 3ION 3IOP 3NAX 3NAY 3NUN 3NUS 3NUU 3NUY 3ORX 3ORZ 3OTU 3PWY 3QC4 3QCQ 3QCS 3QCX 3QCY 3QD0 3QD3 3QD4 3RCJ 3RWP 3RWQ 3SC1 4A06 4A07 4AW0 4AW1 4CT1 4CT2 4RQK 4RQV 4RRV 4XX9 5ACK 5HKM 5HNG 5HO7 5HO8 5LVL 5LV
  • PDBsum: 1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 2XCH 2XCK 3H9O 3HRC 3HRF 3ION 3IOP 3NAX 3NAY 3NUN 3NUS 3NUU 3NUY 3ORX 3ORZ 3OTU 3PWY 3QC4 3QCQ 3QCS 3QCX 3QCY 3QD0 3QD3 3QD4 3RCJ 3RWP 3RWQ 3SC1 4A06 4A07 4AW0 4AW1 4CT1 4CT2 4RQK 4RQV 4RRV 4XX9 5ACK 5HKM 5HNG 5HO7 5HO8 5LVL 5LV
  • DIP: 38372
  • STRING: ENSP00000344220
• Other Databases: GeneCards:  PDPK1  Malacards:  PDPK1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0018105	peptidyl-serine phosphorylation	IBA	biological process
GO:0035556	intracellular signal transduction	IBA	biological process
GO:0004674	protein serine/threonine kinase activity	IBA	molecular function
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	IDA	biological process
GO:0006468	protein phosphorylation	IDA	biological process
GO:0046777	protein autophosphorylation	TAS	biological process
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0004672	protein kinase activity	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0016301	kinase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016310	phosphorylation	IEA	biological process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0030036	actin cytoskeleton organization	TAS	biological process
GO:0035556	intracellular signal transduction	IDA	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0004674	protein serine/threonine kinase activity	TAS	molecular function
GO:0004674	protein serine/threonine kinase activity	TAS	molecular function
GO:0004674	protein serine/threonine kinase activity	TAS	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0032148	activation of protein kinase B activity	TAS	biological process
GO:0032148	activation of protein kinase B activity	TAS	biological process
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0030168	platelet activation	TAS	biological process
GO:0031295	T cell costimulation	TAS	biological process
GO:0038095	Fc-epsilon receptor signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	IEA	biological process
GO:0048041	focal adhesion assembly	IEA	biological process
GO:0005829	cytosol	IEA	cellular component
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0010667	negative regulation of cardiac muscle cell apoptotic process	IEA	biological process
GO:0006972	hyperosmotic response	IEA	biological process
GO:0043524	negative regulation of neuron apoptotic process	IEA	biological process
GO:0043204	perikaryon	IEA	cellular component
GO:0019901	protein kinase binding	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0005158	insulin receptor binding	IEA	molecular function
GO:0004676	3-phosphoinositide-dependent protein kinase activity	IEA	molecular function
GO:0043304	regulation of mast cell degranulation	IEA	biological process
GO:0034122	negative regulation of toll-like receptor signaling pathway	IEA	biological process
GO:0014069	postsynaptic density	IEA	cellular component
GO:0010594	regulation of endothelial cell migration	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0004676	3-phosphoinositide-dependent protein kinase activity	IEA	molecular function
GO:0003323	type B pancreatic cell development	IEA	biological process
GO:0004674	protein serine/threonine kinase activity	IDA	molecular function
GO:0004676	3-phosphoinositide-dependent protein kinase activity	IDA	molecular function
GO:0016004	phospholipase activator activity	IMP	molecular function
GO:0043274	phospholipase binding	IPI	molecular function
GO:0042995	cell projection	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0006469	negative regulation of protein kinase activity	IDA	biological process
GO:0018107	peptidyl-threonine phosphorylation	IDA	biological process
GO:0032148	activation of protein kinase B activity	IDA	biological process
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	IDA	biological process
GO:0016477	cell migration	IMP	biological process
GO:0032869	cellular response to insulin stimulus	IMP	biological process
GO:0007173	epidermal growth factor receptor signaling pathway	IMP	biological process
GO:0010518	positive regulation of phospholipase activity	IMP	biological process
GO:0019722	calcium-mediated signaling	IMP	biological process
GO:0071364	cellular response to epidermal growth factor stimulus	IMP	biological process
GO:1903078	positive regulation of protein localization to plasma membrane	IMP	biological process
GO:0043536	positive regulation of blood vessel endothelial cell migration	IMP	biological process
GO:1905564	positive regulation of vascular endothelial cell proliferation	IMP	biological process
GO:0045766	positive regulation of angiogenesis	IMP	biological process
GO:2000352	negative regulation of endothelial cell apoptotic process	IMP	biological process
GO:1903672	positive regulation of sprouting angiogenesis	IMP	biological process
GO:0005925	focal adhesion	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0097191	extrinsic apoptotic signaling pathway	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa04151	PI3K-Akt signaling pathway
hsa04510	Focal adhesion
hsa05205	Proteoglycans in cancer
hsa04150	mTOR signaling pathway
hsa04140	Autophagy - animal
hsa04910	Insulin signaling pathway
hsa04210	Apoptosis
hsa04722	Neurotrophin signaling pathway
hsa04071	Sphingolipid signaling pathway
hsa04152	AMPK signaling pathway
hsa04068	FoxO signaling pathway
hsa04919	Thyroid hormone signaling pathway
hsa05231	Choline metabolism in cancer
hsa04660	T cell receptor signaling pathway
hsa04931	Insulin resistance
hsa05145	Toxoplasmosis
hsa03320	PPAR signaling pathway
hsa05215	Prostate cancer
hsa04664	Fc epsilon RI signaling pathway
hsa05223	Non-small cell lung cancer
hsa05213	Endometrial cancer
hsa01524	Platinum drug resistance
hsa04960	Aldosterone-regulated sodium reabsorption
P06959	CCKR signaling map
P06959	CCKR signaling map

Diseases

Associated diseases	References
Prostate cancer	PMID:26294745
lung non-small cell carcinoma	PMID:25064732
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq