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Gene id 51619
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol UBE2D4   Gene   UCSC   Ensembl
Aliases HBUCE1
Gene name ubiquitin conjugating enzyme E2 D4 (putative)
Alternate names ubiquitin-conjugating enzyme E2 D4, E2 ubiquitin-conjugating enzyme D4, ubiquitin carrier protein D4, ubiquitin conjugating enzyme E2D 4 (putative), ubiquitin-conjugating enzyme HBUCE1, ubiquitin-protein ligase D4,
Gene location 7p13 (172983770: 173035444)     Exons: 4     NC_000005.10

Protein Summary
Protein general information Q9Y2X8  

Name: Ubiquitin conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin protein ligase D4)

Length: 147  Mass: 16649

Sequence MALKRIQKELTDLQRDPPAQCSAGPVGDDLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTKIYH
PNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPEIAHTYKADREKYNRLAREWTQKYAM
Structural information
Interpro:  IPR000608  IPR023313  IPR016135  
Prosite:   PS00183 PS50127
CDD:   cd00195
MINT:  
STRING:   ENSP00000222402
Other Databases GeneCards:  UBE2D4  Malacards:  UBE2D4

Gene ontology

Expand All | Collapse All
GO accessionTerm nameEvidence codeGo category
GO:0000151 ubiquitin ligase complex
 IBA cellular component
GO:0006511 ubiquitin-dependent prote
in catabolic process
 IBA biological process
GO:0031625 ubiquitin protein ligase
binding
 IBA molecular function
GO:0070534 protein K63-linked ubiqui
tination
 IBA biological process
GO:0070936 protein K48-linked ubiqui
tination
 IBA biological process
GO:0070979 protein K11-linked ubiqui
tination
 IBA biological process
GO:0000209 protein polyubiquitinatio
n
 IBA biological process
GO:0005634 nucleus
 IBA cellular component
GO:0061631 ubiquitin conjugating enz
yme activity
 IBA molecular function
GO:0016740 transferase activity
 IEA molecular function
GO:0000166 nucleotide binding
 IEA molecular function
GO:0005524 ATP binding
 IEA molecular function
GO:0061631 ubiquitin conjugating enz
yme activity
 IEA molecular function
GO:0061631 ubiquitin conjugating enz
yme activity
 IDA molecular function
GO:0016567 protein ubiquitination
 IDA biological process
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0016567 protein ubiquitination
 IEA biological process
GO:0044314 protein K27-linked ubiqui
tination
 IDA biological process
GO:0035519 protein K29-linked ubiqui
tination
 IDA biological process
GO:0004842 ubiquitin-protein transfe
rase activity
 IDA molecular function
GO:0070979 protein K11-linked ubiqui
tination
 IDA biological process
GO:0070936 protein K48-linked ubiqui
tination
 IDA biological process
GO:0070534 protein K63-linked ubiqui
tination
 IDA biological process
GO:0085020 protein K6-linked ubiquit
ination
 IDA biological process

KEGG pathways

Expand All | Collapse All

Pathway idPathway name
hsa05131Shigellosis
hsa04141Protein processing in endoplasmic reticulum
hsa04120Ubiquitin mediated proteolysis

Diseases

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Associated diseases References
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia
13 (5 controls,
8 cases)
 Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
17327269 Teratozoos
permia
19 (6 controls
, 13 cases)
 Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract