• Gene id: 51567

Gene Summary

• Gene Symbol: TDP2   Gene   UCSC   Ensembl
• Aliases: AD022, EAP2, EAPII, TTRAP, dJ30M3.3, hTDP2
• Gene name: tyrosyl-DNA phosphodiesterase 2
• Alternate names: tyrosyl-DNA phosphodiesterase 2, 5'-Tyr-DNA phosphodiesterase, 5'-tyrosyl-DNA phosphodiesterase, ETS1-associated protein 2, ETS1-associated protein II, TRAF and TNF receptor-associated protein, VPg unlinkase, epididymis secretory sperm binding protein, tyr-DNA ph,
• Gene location: 6p22.3 (24666898: 24649978)     Exons: 7     NC_000006.12
• Gene summary(Entrez): This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B
• OMIM: 607388

Protein Summary

• Protein general information: O95551  
  • Name: Tyrosyl DNA phosphodiesterase 2 (Tyr DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4. ) (5' tyrosyl DNA phosphodiesterase) (5' Tyr DNA phosphodiesterase) (ETS1 associated protein 2) (ETS1 associated protein II) (EAPII) (TRAF and TNF receptor associated protein
  • Length: 362  
  • Mass: 40930
  • Tissue specificity: Widely expressed (PubMed
• Sequence:

  MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNSYFEPPVEESALERRP
  ETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVIFL
  QEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTS
  HLESTRGHAAERMNQLKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQ
  MNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDIIL

• Structural information:
  • Interpro: IPR036691  IPR005135  IPR009060  
  • PDB: 5INO 5J3P 5J3S
  • PDBsum: 5INO 5J3P 5J3S
  • STRING: ENSP00000367440
• Other Databases: GeneCards:  TDP2  Malacards:  TDP2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005654	nucleoplasm	IBA	cellular component
GO:0003697	single-stranded DNA binding	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0006302	double-strand break repair	IBA	biological process
GO:0016605	PML body	IBA	cellular component
GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	IBA	molecular function
GO:0036317	tyrosyl-RNA phosphodiesterase activity	IDA	molecular function
GO:0030145	manganese ion binding	IDA	molecular function
GO:0000287	magnesium ion binding	IDA	molecular function
GO:0000287	magnesium ion binding	IDA	molecular function
GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	IDA	molecular function
GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	IDA	molecular function
GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	IDA	molecular function
GO:0016605	PML body	IDA	cellular component
GO:0006302	double-strand break repair	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0003697	single-stranded DNA binding	IDA	molecular function
GO:0000287	magnesium ion binding	TAS	molecular function
GO:0048666	neuron development	IMP	biological process
GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	IMP	molecular function
GO:0006302	double-strand break repair	IMP	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0004518	nuclease activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0006281	DNA repair	IEA	biological process
GO:0016032	viral process	IEA	biological process
GO:0006974	cellular response to DNA damage stimulus	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0003714	transcription corepressor activity	TAS	molecular function
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005730	nucleolus	IEA	cellular component
GO:0016605	PML body	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0016604	nuclear body	IDA	cellular component
GO:0016235	aggresome	IDA	cellular component
GO:1903507	negative regulation of nucleic acid-templated transcription	IEA	biological process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Autosomal recessive spinocerebellar ataxias	KEGG:H01891
Autosomal recessive spinocerebellar ataxias	KEGG:H01891
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)