• Gene id: 5154

Gene Summary

• Gene Symbol: PDGFA   Gene   UCSC   Ensembl
• Aliases: PDGF-A, PDGF1
• Gene name: platelet derived growth factor subunit A
• Alternate names: platelet-derived growth factor subunit A, PDGF A-chain, PDGF subunit A, platelet-derived growth factor A-chain, platelet-derived growth factor alpha chain, platelet-derived growth factor alpha polypeptide,
• Gene location: 7p22.3 (520667: 497244)     Exons: 9     NC_000007.14
• Gene summary(Entrez): This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor sub
• OMIM: 173430

Protein Summary

• Protein general information: P04085  
  • Name: Platelet derived growth factor subunit A (PDGF subunit A) (PDGF 1) (Platelet derived growth factor A chain) (Platelet derived growth factor alpha polypeptide)
  • Length: 211  
  • Mass: 24043
• Sequence:

  MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLDTSLRAHGVHATKHVP
  EKRPLPIRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSV
  KVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNPDYREEDTGRPRESGKKRKRKRLKPT

• Structural information:
  • Interpro: IPR029034  IPR023581  IPR000072  IPR006782  
  • Prosite: PS00249 PS50278
  • CDD: cd00135
  • PDB: 3MJK
  • PDBsum: 3MJK
  • DIP: 5735
  • STRING: ENSP00000346508
• Other Databases: GeneCards:  PDGFA  Malacards:  PDGFA

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005161	platelet-derived growth factor receptor binding	IBA	molecular function
GO:0005615	extracellular space	IBA	cellular component
GO:0008284	positive regulation of cell population proliferation	IBA	biological process
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IBA	biological process
GO:0030335	positive regulation of cell migration	IBA	biological process
GO:0031954	positive regulation of protein autophosphorylation	IBA	biological process
GO:0043406	positive regulation of MAP kinase activity	IBA	biological process
GO:0048008	platelet-derived growth factor receptor signaling pathway	IBA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	biological process
GO:0070851	growth factor receptor binding	IBA	molecular function
GO:0008083	growth factor activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0051781	positive regulation of cell division	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0008083	growth factor activity	IEA	molecular function
GO:0007275	multicellular organism development	IEA	biological process
GO:0007267	cell-cell signaling	TAS	biological process
GO:0008284	positive regulation of cell population proliferation	IDA	biological process
GO:0005518	collagen binding	IDA	molecular function
GO:0000165	MAPK cascade	TAS	biological process
GO:0002576	platelet degranulation	TAS	biological process
GO:0030198	extracellular matrix organization	TAS	biological process
GO:0031093	platelet alpha granule lumen	TAS	cellular component
GO:0051897	positive regulation of protein kinase B signaling	TAS	biological process
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005161	platelet-derived growth factor receptor binding	IDA	molecular function
GO:0005161	platelet-derived growth factor receptor binding	IDA	molecular function
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:1990401	embryonic lung development	ISS	biological process
GO:0005161	platelet-derived growth factor receptor binding	IPI	molecular function
GO:0046982	protein heterodimerization activity	IPI	molecular function
GO:0048407	platelet-derived growth factor binding	IPI	molecular function
GO:0005615	extracellular space	IDA	cellular component
GO:0008284	positive regulation of cell population proliferation	IDA	biological process
GO:0008284	positive regulation of cell population proliferation	IDA	biological process
GO:0008284	positive regulation of cell population proliferation	IDA	biological process
GO:0009611	response to wounding	IDA	biological process
GO:0014910	regulation of smooth muscle cell migration	IDA	biological process
GO:0030335	positive regulation of cell migration	IDA	biological process
GO:0008284	positive regulation of cell population proliferation	IDA	biological process
GO:0008284	positive regulation of cell population proliferation	IDA	biological process
GO:0042060	wound healing	TAS	biological process
GO:0009986	cell surface	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0010512	negative regulation of phosphatidylinositol biosynthetic process	IDA	biological process
GO:0010544	negative regulation of platelet activation	IDA	biological process
GO:0048008	platelet-derived growth factor receptor signaling pathway	IDA	biological process
GO:0048008	platelet-derived growth factor receptor signaling pathway	IDA	biological process
GO:0048008	platelet-derived growth factor receptor signaling pathway	IDA	biological process
GO:0048146	positive regulation of fibroblast proliferation	IDA	biological process
GO:0048146	positive regulation of fibroblast proliferation	IDA	biological process
GO:0050919	negative chemotaxis	IDA	biological process
GO:0001775	cell activation	TAS	biological process
GO:0032956	regulation of actin cytoskeleton organization	TAS	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0043406	positive regulation of MAP kinase activity	IDA	biological process
GO:0031954	positive regulation of protein autophosphorylation	IDA	biological process
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IDA	biological process
GO:2000278	regulation of DNA biosynthetic process	IDA	NOT|biological process
GO:2000278	regulation of DNA biosynthetic process	IDA	NOT|biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	IDA	biological process
GO:0030335	positive regulation of cell migration	IDA	biological process
GO:0072124	regulation of glomerular mesangial cell proliferation	IDA	NOT|biological process
GO:0051897	positive regulation of protein kinase B signaling	IDA	biological process
GO:0008083	growth factor activity	IDA	molecular function
GO:0030036	actin cytoskeleton organization	ISS	biological process
GO:0030031	cell projection assembly	ISS	biological process
GO:0009887	animal organ morphogenesis	ISS	biological process
GO:0048286	lung alveolus development	ISS	biological process
GO:0060683	regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling	ISS	biological process
GO:0005902	microvillus	ISS	cellular component
GO:0001942	hair follicle development	ISS	biological process
GO:0001525	angiogenesis	ISS	biological process
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	ISS	biological process
GO:0043588	skin development	ISS	biological process
GO:0043410	positive regulation of MAPK cascade	IMP	biological process
GO:0002053	positive regulation of mesenchymal cell proliferation	ISS	biological process

KEGG pathways

Pathway id	Pathway name
hsa05200	Pathways in cancer
hsa04151	PI3K-Akt signaling pathway
hsa04010	MAPK signaling pathway
hsa05206	MicroRNAs in cancer
hsa04014	Ras signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa04015	Rap1 signaling pathway
hsa04510	Focal adhesion
hsa05202	Transcriptional misregulation in cancer
hsa04072	Phospholipase D signaling pathway
hsa04630	JAK-STAT signaling pathway
hsa05418	Fluid shear stress and atherosclerosis
hsa05231	Choline metabolism in cancer
hsa04540	Gap junction
hsa05215	Prostate cancer
hsa05214	Glioma
hsa01521	EGFR tyrosine kinase inhibitor resistance
hsa05218	Melanoma

Diseases

Associated diseases	References
Glioma	KEGG:H00042
Malignant pleural mesothelioma	KEGG:H00015
Glioma	KEGG:H00042
Malignant pleural mesothelioma	KEGG:H00015
leiomyoma	PMID:16294022
Breast cancer	PMID:8619189
prostate adenocarcinoma	PMID:7524068
Leydig cell tumor	PMID:11994382
Malignant glioma	PMID:21490965
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq