• Gene id: 51538

Gene Summary

• Gene Symbol: ZCCHC17   Gene   UCSC   Ensembl
• Aliases: HSPC251, PS1D, pNO40
• Gene name: zinc finger CCHC-type containing 17
• Alternate names: nucleolar protein of 40 kDa, nucleolar protein 40, pnn-interacting nucleolar protein, putative S1 RNA binding domain protein, zinc finger CCHC domain-containing protein 17, zinc finger, CCHC domain containing 17,
• Gene location: 1p35.2 (31296981: 31365721)     Exons: 9     NC_000001.11

Protein Summary

• Protein general information: Q9NP64  
  • Name: Nucleolar protein of 40 kDa (pNO40) (Pnn interacting nucleolar protein) (Putative S1 RNA binding domain protein) (PS1D protein) (Zinc finger CCHC domain containing protein 17)
  • Length: 241  
  • Mass: 27570
• Sequence:

  MNSGRPETMENLPALYTIFQGEVAMVTDYGAFIKIPGCRKQGLVHRTHMSSCRVDKPSEIVDVGDKVWVKLIGRE
  MKNDRIKVSLSMKVVNQGTGKDLDPNNVIIEQEERRRRSFQDYTGQKITLEAVLNTTCKKCGCKGHFAKDCFMQP
  GGTKYSLIPDEEEEKEEAKSAEFEKPDPTRNPSRKRKKEKKKKKHRDRKSSDSDSSDSESDTGKRARHTSKDSKA
  AKKKKKKKKHKKKHKE

• Structural information:
  • Protein Domains: (16..8-)
    (/note="S1-motif)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00180"-)
  • Interpro: IPR012340  IPR022967  IPR003029  IPR001878  
  • Prosite: PS50126 PS50158
  • PDB: 2CQO
  • PDBsum: 2CQO
  • STRING: ENSP00000480986
• Other Databases: GeneCards:  ZCCHC17  Malacards:  ZCCHC17

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0008270	zinc ion binding	IEA	molecular function
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005730	nucleolus	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881