• Gene id: 51506

Gene Summary

• Gene Symbol: UFC1   Gene   UCSC   Ensembl
• Aliases: HSPC155, NEDSG
• Gene name: ubiquitin-fold modifier conjugating enzyme 1
• Alternate names: ubiquitin-fold modifier-conjugating enzyme 1, Ufm1-conjugating enzyme 1,
• Gene location: 1q23.3 (161132702: 161158855)     Exons: 8     NC_000001.11
• Gene summary(Entrez): UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008]
• OMIM: 610554

Protein Summary

• Protein general information: Q9Y3C8  
  • Name: Ubiquitin fold modifier conjugating enzyme 1 (Ufm1 conjugating enzyme 1)
  • Length: 167  
  • Mass: 19458
• Sequence:

  MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNADNDWFRLESNKEGTRWFGKCWYIHDL
  LKYEFDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEI
  PDLIQKGVIQHKEKCNQ

• Structural information:
  • Interpro: IPR016135  IPR014806  
  • PDB: 2K07 2Z6O 2Z6P 3EVX
  • PDBsum: 2K07 2Z6O 2Z6P 3EVX
  • STRING: ENSP00000356982
• Other Databases: GeneCards:  UFC1  Malacards:  UFC1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:1990592	protein K69-linked ufmylation	IBA	biological process
GO:0071568	UFM1 transferase activity	IBA	molecular function
GO:0071569	protein ufmylation	IDA	biological process
GO:1990592	protein K69-linked ufmylation	IDA	biological process
GO:0061657	UFM1 conjugating enzyme activity	IDA	molecular function
GO:0071569	protein ufmylation	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007420	brain development	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0034976	response to endoplasmic reticulum stress	IDA	biological process
GO:0071569	protein ufmylation	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881