• Gene id: 51504

Gene Summary

• Gene Symbol: TRMT112   Gene   UCSC   Ensembl
• Aliases: HSPC152, HSPC170, TRM112, TRMT11-2, hTrm112
• Gene name: tRNA methyltransferase subunit 11-2
• Alternate names: multifunctional methyltransferase subunit TRM112-like protein, TRM112-like protein, tRNA methyltransferase 11-2 homolog, tRNA methyltransferase 112 homolog,
• Gene location: 11q13.1 (3650102: 3630766)     Exons: 13     NC_000001.11
• OMIM: 618630

Protein Summary

• Protein general information: Q9UI30  
  • Name: Multifunctional methyltransferase subunit TRM112 like protein (tRNA methyltransferase 112 homolog)
  • Length: 125  
  • Mass: 14199
• Sequence:

  MKLLTHNLLSSHVRGVGSRGFPLRLQATEVRICPVEFNPNFVARMIPKVEWSAFLEAADNLRLIQVPKGPVEGYE
  ENEEFLRTMHHLLLEVEVIEGTLQCPESGRMFPISRGIPNMLLSEEETES

• Structural information:
  • Protein Domains: (2..11-)
    (/note="TRM112"-)
  • Interpro: IPR039127  IPR005651  
  • PDB: 6G4W 6H1D 6H1E 6H2U 6H2V 6K0X 6KMR 6KMS 6PED
  • PDBsum: 6G4W 6H1D 6H1E 6H2U 6H2V 6K0X 6KMR 6KMS 6PED
  • STRING: ENSP00000438349
• Other Databases: GeneCards:  TRMT112  Malacards:  TRMT112

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq