• Gene id: 51491

Gene Summary

• Gene Symbol: NOP16   Gene   UCSC   Ensembl
• Aliases: HSPC111, HSPC185
• Gene name: NOP16 nucleolar protein
• Alternate names: nucleolar protein 16, HBV pre-S2 trans-regulated protein 3, NOP16 nucleolar protein homolog, hypothetical protein HSPC111, nucleolar protein 16 homolog,
• Gene location: 5q35.2 (35943712: 35934517)     Exons: 5     NC_000017.11
• Gene summary(Entrez): This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provi
• OMIM: 612861

Protein Summary

• Protein general information: Q9Y3C1  
  • Name: Nucleolar protein 16 (HBV pre S2 trans regulated protein 3)
  • Length: 178  
  • Mass: 21188
• Sequence:

  MPKAKGKTRRQKFGYSVNRKRLNRNARRKAAPRIECSHIRHAWDHAKSVRQNLAEMGLAVDPNRAVPLRKRKVKA
  MEVDIEERPKELVRKPYVLNDLEAEASLPEKKGNTLSRDLIDYVRYMVENHGEDYKAMARDEKNYYQDTPKQIRS
  KINVYKRFYPAEWQDFLDSLQKRKMEVE

• Structural information:
  • Interpro: IPR019002  
  • STRING: ENSP00000480832
• Other Databases: GeneCards:  NOP16  Malacards:  NOP16

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042273	ribosomal large subunit biogenesis	IBA	biological process
GO:0005730	nucleolus	IBA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005730	nucleolus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)