• Gene id: 51455

Gene Summary

• Gene Symbol: REV1   Gene   UCSC   Ensembl
• Aliases: AIBP80, REV1L
• Gene name: REV1 DNA directed polymerase
• Alternate names: DNA repair protein REV1, REV1 homolog, REV1, polymerase (DNA directed), REV1- like, alpha integrin-binding protein 80, rev1-like terminal deoxycytidyl transferase,
• Gene location: 2q11.2 (99490122: 99400476)     Exons: 29     NC_000002.12
• Gene summary(Entrez): This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that
• OMIM: 606134

Protein Summary

• Protein general information: Q9UBZ9  
  • Name: DNA repair protein REV1 (EC 2.7.7. ) (Alpha integrin binding protein 80) (AIBP80) (Rev1 like terminal deoxycytidyl transferase)
  • Length: 1251  
  • Mass: 138248
  • Tissue specificity: Ubiquitous. {ECO
• Sequence:

  MRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTDPSAEELRKLMMLHG
  GQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVESIKAGRLLSYIPYQLYTKQSSVQKGLSFNPVCRP
  EDPLPGPSNIAKQLNNRVNHIVKKIETENEVKVNGMNSWNEEDENNDFSFVDLEQTSPGRKQNGIPHPRGSTAIF
  NGHTPSSNGALKTQDCLVPMVNSVASRLSPAFSQEEDKAEKSSTDFRDCTLQQLQQSTRNTDALRNPHRTNSFSL
  SPLHSNTKINGAHHSTVQGPSSTKSTSSVSTFSKAAPSVPSKPSDCNFISNFYSHSRLHHISMWKCELTEFVNTL
  QRQSNGIFPGREKLKKMKTGRSALVVTDTGDMSVLNSPRHQSCIMHVDMDCFFVSVGIRNRPDLKGKPVAVTSNR
  GTGRAPLRPGANPQLEWQYYQNKILKGKAADIPDSSLWENPDSAQANGIDSVLSRAEIASCSYEARQLGIKNGMF
  FGHAKQLCPNLQAVPYDFHAYKEVAQTLYETLASYTHNIEAVSCDEALVDITEILAETKLTPDEFANAVRMEIKD
  QTKCAASVGIGSNILLARMATRKAKPDGQYHLKPEEVDDFIRGQLVTNLPGVGHSMESKLASLGIKTCGDLQYMT
  MAKLQKEFGPKTGQMLYRFCRGLDDRPVRTEKERKSVSAEINYGIRFTQPKEAEAFLLSLSEEIQRRLEATGMKG
  KRLTLKIMVRKPGAPVETAKFGGHGICDNIARTVTLDQATDNAKIIGKAMLNMFHTMKLNISDMRGVGIHVNQLV
  PTNLNPSTCPSRPSVQSSHFPSGSYSVRDVFQVQKAKKSTEEEHKEVFRAAVDLEISSASRTCTFLPPFPAHLPT
  SPDTNKAESSGKWNGLHTPVSVQSRLNLSIEVPSPSQLDQSVLEALPPDLREQVEQVCAVQQAESHGDKKKEPVN
  GCNTGILPQPVGTVLLQIPEPQESNSDAGINLIALPAFSQVDPEVFAALPAELQRELKAAYDQRQRQGENSTHQQ
  SASASVPKNPLLHLKAAVKEKKRNKKKKTIGSPKRIQSPLNNKLLNSPAKTLPGACGSPQKLIDGFLKHEGPPAE
  KPLEELSASTSGVPGLSSLQSDPAGCVRPPAPNLAGAVEFNDVKTLLREWITTISDPMEEDILQVVKYCTDLIEE
  KDLEKLDLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQTYGSTLKVT

• Structural information:
  • Protein Domains: (44..13-)
    (/note="BRCT-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00033-)
    (419..65-)
    (/note="UmuC-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00216"-)
  • Interpro: IPR001357  IPR036420  IPR036775  IPR017961  IPR025527   IPR012112  IPR031991  IPR038401  IPR001126  
  • Prosite: PS50172 PS50173
  • PDB: 2EBW 2LSI 2LSK 2LSY 2N1G 3GQC 3VU7 4BA9 4EXT 4GK0 4GK5 5VZM 6ASR 6AXD
  • PDBsum: 2EBW 2LSI 2LSK 2LSY 2N1G 3GQC 3VU7 4BA9 4EXT 4GK0 4GK5 5VZM 6ASR 6AXD
  • STRING: ENSP00000258428
• Other Databases: GeneCards:  REV1  Malacards:  REV1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0070987	error-free translesion synthesis	IBA	biological process
GO:0003887	DNA-directed DNA polymerase activity	IBA	molecular function
GO:0017125	deoxycytidyl transferase activity	IBA	molecular function
GO:0042276	error-prone translesion synthesis	IBA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0006281	DNA repair	IEA	biological process
GO:0016779	nucleotidyltransferase activity	IEA	molecular function
GO:0003684	damaged DNA binding	IEA	molecular function
GO:0042276	error-prone translesion synthesis	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016779	nucleotidyltransferase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0006281	DNA repair	IEA	biological process
GO:0006974	cellular response to DNA damage stimulus	IEA	biological process
GO:0071897	DNA biosynthetic process	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0003684	damaged DNA binding	TAS	molecular function
GO:0006260	DNA replication	TAS	biological process
GO:0017125	deoxycytidyl transferase activity	TAS	molecular function
GO:0042276	error-prone translesion synthesis	TAS	biological process
GO:0042276	error-prone translesion synthesis	TAS	biological process
GO:0042276	error-prone translesion synthesis	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0019985	translesion synthesis	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0042276	error-prone translesion synthesis	IEA	biological process
GO:0017125	deoxycytidyl transferase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0009411	response to UV	IDA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0042276	error-prone translesion synthesis	TAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa03460	Fanconi anemia pathway

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881