• Gene id: 51430

Gene Summary

• Gene Symbol: SUCO   Gene   UCSC   Ensembl
• Aliases: C1orf9, CH1, OPT, SLP1
• Gene name: SUN domain containing ossification factor
• Alternate names: SUN domain-containing ossification factor, SUN-like protein 1, membrane protein CH1, osteopotentia,
• Gene location: 1q24.3 (158672055: 158666674)     Exons: 3     NC_000004.12

Protein Summary

• Protein general information: Q9UBS9  
  • Name: SUN domain containing ossification factor (Membrane protein CH1) (Protein osteopotentia homolog) (SUN like protein 1)
  • Length: 1254  
  • Mass: 139430
  • Tissue specificity: Highly expressed in pancreas and testis and to a lower extent in prostate, ovary, heart, thymus, small intestine and spleen. {ECO
• Sequence:

  MKKHRRALALVSCLFLCSLVWLPSWRVCCKESSSASASSYYSQDDNCALENEDVQFQKKDEREGPINAESLGKSG
  SNLPISPKEHKLKDDSIVDVQNTESKKLSPPVVETLPTVDLHEESSNAVVDSETVENISSSSTSEITPISKLDEI
  EKSGTIPIAKPSETEQSETDCDVGEALDASAPIEQPSFVSPPDSLVGQHIENVSSSHGKGKITKSEFESKVSASE
  QGGGDPKSALNASDNLKNESSDYTKPGDIDPTSVASPKDPEDIPTFDEWKKKVMEVEKEKSQSMHASSNGGSHAT
  KKVQKNRNNYASVECGAKILAANPEAKSTSAILIENMDLYMLNPCSTKIWFVIELCEPIQVKQLDIANYELFSST
  PKDFLVSISDRYPTNKWIKLGTFHGRDERNVQSFPLDEQMYAKYVKMFIKYIKVELLSHFGSEHFCPLSLIRVFG
  TSMVEEYEEIADSQYHSERQELFDEDYDYPLDYNTGEDKSSKNLLGSATNAILNMVNIAANILGAKTEDLTEGNK
  SISENATATAAPKMPESTPVSTPVPSPEYVTTEVHTHDMEPSTPDTPKESPIVQLVQEEEEEASPSTVTLLGSGE
  QEDESSPWFESETQIFCSELTTICCISSFSEYIYKWCSVRVALYRQRSRTALSKGKDYLVLAQPPLLLPAESVDV
  SVLQPLSGELENTNIEREAETVVLGDLSSSMHQDDLVNHTVDAVELEPSHSQTLSQSLLLDITPEINPLPKIEVS
  ESVEYEAGHIPSPVIPQESSVEIDNETEQKSESFSSIEKPSITYETNKVNELMDNIIKEDVNSMQIFTKLSETIV
  PPINTATVPDNEDGEAKMNIADTAKQTLISVVDSSSLPEVKEEEQSPEDALLRGLQRTATDFYAELQNSTDLGYA
  NGNLVHGSNQKESVFMRLNNRIKALEVNMSLSGRYLEELSQRYRKQMEEMQKAFNKTIVKLQNTSRIAEEQDQRQ
  TEAIQLLQAQLTNMTQLVSNLSATVAELKREVSDRQSYLVISLVLCVVLGLMLCMQRCRNTSQFDGDYISKLPKS
  NQYPSPKRCFSSYDDMNLKRRTSFPLMRSKSLQLTGKEVDPNDLYIVEPLKFSPEKKKKRCKYKIEKIETIKPEE
  PLHPIANGDIKGRKPFTNQRDFSNMGEVYHSSYKGPPSEGSSETSSQSEESYFCGISACTSLCNGQSQKTKTEKR
  ALKRRRSKVQDQGKLIKTLIQTKSGSLPSLHDIIKGNKEITVGTFGVTAVSGHI

• Structural information:
  • Protein Domains: (284..45-)
    (/note="SUN-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00802"-)
  • Interpro: IPR008979  IPR012919  
  • Prosite: PS51469
  • STRING: ENSP00000356696
• Other Databases: GeneCards:  SUCO  Malacards:  SUCO

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0016020	membrane	IBA	cellular component
GO:0046850	regulation of bone remodeling	IBA	biological process
GO:0045669	positive regulation of osteoblast differentiation	ISS	biological process
GO:0005791	rough endoplasmic reticulum	ISS	cellular component
GO:0046850	regulation of bone remodeling	ISS	biological process
GO:0032967	positive regulation of collagen biosynthetic process	ISS	biological process
GO:0016020	membrane	ISS	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0001503	ossification	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007275	multicellular organism development	IEA	biological process
GO:0045669	positive regulation of osteoblast differentiation	IEA	biological process
GO:0005791	rough endoplasmic reticulum	IEA	cellular component
GO:0046850	regulation of bone remodeling	IEA	biological process
GO:0032967	positive regulation of collagen biosynthetic process	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0030867	rough endoplasmic reticulum membrane	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881