• Gene id: 5142

Gene Summary

• Gene Symbol: PDE4B   Gene   UCSC   Ensembl
• Aliases: DPDE4, PDEIVB
• Gene name: phosphodiesterase 4B
• Alternate names: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, dunce-like phosphodiesterase E4, phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila),
• Gene location: 1p31.3 (65792509: 66374578)     Exons: 11     NC_000001.11
• Gene summary(Entrez): This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered act
• OMIM: 600127

Protein Summary

• Protein general information: Q07343  
  • Name: cAMP specific 3',5' cyclic phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32)
  • Length: 736  
  • Mass: 83343
  • Tissue specificity: Expressed in brain, heart, lung and skeletal muscle.
• Sequence:

  MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPT
  TLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMS
  RNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEE
  LDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
  KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQER
  DLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDH
  PGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSL
  LADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
  SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLM
  EKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT

• Structural information:
  • Protein Domains: (330..65-)
    (/note="PDEase-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01192"-)
  • Interpro: IPR003607  IPR040844  IPR023088  IPR002073  IPR036971   IPR023174  
  • Prosite: PS00126 PS51845
  • CDD: cd00077
  • PDB: 1F0J 1JP1 1JP2 1RO6 1RO9 1ROR 1TB5 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1Y2H 1Y2J 2CHM 2QYL 3D3P 3FRG 3G45 3GWT 3HC8 3HDZ 3HMV 3KKT 3LY2 3O0J 3O56 3O57 3W5E 3WD9 4KP6 4MYQ 4NW7 4WZI 4X0F 5K6J 5LAQ 5OHJ 6BOJ
  • PDBsum: 1F0J 1JP1 1JP2 1RO6 1RO9 1ROR 1TB5 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1Y2H 1Y2J 2CHM 2QYL 3D3P 3FRG 3G45 3GWT 3HC8 3HDZ 3HMV 3KKT 3LY2 3O0J 3O56 3O57 3W5E 3WD9 4KP6 4MYQ 4NW7 4WZI 4X0F 5K6J 5LAQ 5OHJ 6BOJ
  • STRING: ENSP00000332116
• Other Databases: GeneCards:  PDE4B  Malacards:  PDE4B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0044325	ion channel binding	IBA	molecular function
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IEA	molecular function
GO:0006198	cAMP catabolic process	IEA	biological process
GO:0007165	signal transduction	IEA	biological process
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA	molecular function
GO:0008081	phosphoric diester hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	TAS	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0071944	cell periphery	IEA	cellular component
GO:0071222	cellular response to lipopolysaccharide	IEA	biological process
GO:0050900	leukocyte migration	IEA	biological process
GO:0035690	cellular response to drug	IEA	biological process
GO:0030593	neutrophil chemotaxis	IEA	biological process
GO:0008021	synaptic vesicle	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005813	centrosome	IEA	cellular component
GO:0001780	neutrophil homeostasis	IEA	biological process
GO:0060076	excitatory synapse	IEA	cellular component
GO:0043197	dendritic spine	IEA	cellular component
GO:0043015	gamma-tubulin binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0014069	postsynaptic density	IEA	cellular component
GO:0000930	gamma-tubulin complex	IEA	cellular component
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IDA	molecular function
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISS	molecular function
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IGI	molecular function
GO:0044325	ion channel binding	ISS	molecular function
GO:0030552	cAMP binding	IGI	molecular function
GO:0001780	neutrophil homeostasis	ISS	biological process
GO:0030593	neutrophil chemotaxis	ISS	biological process
GO:0032743	positive regulation of interleukin-2 production	IMP	biological process
GO:0035690	cellular response to drug	ISS	biological process
GO:0050900	leukocyte migration	ISS	biological process
GO:0071222	cellular response to lipopolysaccharide	ISS	biological process
GO:0071872	cellular response to epinephrine stimulus	ISS	biological process
GO:1901898	negative regulation of relaxation of cardiac muscle	ISS	biological process
GO:0005891	voltage-gated calcium channel complex	ISS	cellular component
GO:0030018	Z disc	ISS	cellular component
GO:0032729	positive regulation of interferon-gamma production	IMP	biological process
GO:0050852	T cell receptor signaling pathway	IMP	biological process
GO:0086004	regulation of cardiac muscle cell contraction	ISS	biological process
GO:1901841	regulation of high voltage-gated calcium channel activity	ISS	biological process
GO:0006198	cAMP catabolic process	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04024	cAMP signaling pathway
hsa00230	Purine metabolism
hsa05032	Morphine addiction
hsa04928	Parathyroid hormone synthesis, secretion and action

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq