• Gene id: 51409

Gene Summary

• Gene Symbol: HEMK1   Gene   UCSC   Ensembl
• Aliases: HEMK, MPRMC, MTQ1
• Gene name: HemK methyltransferase family member 1
• Alternate names: MTRF1L release factor glutamine methyltransferase, HEMK homolog 7kb, m.HsaHemKP, testis secretory sperm-binding protein Li 225n,
• Gene location: 3p21.31 (50569151: 50596165)     Exons: 14     NC_000003.12
• OMIM: 102981

Protein Summary

• Protein general information: Q9Y5R4  
  • Name: MTRF1L release factor glutamine methyltransferase (EC 2.1.1.297) (HemK methyltransferase family member 1) (M.HsaHemKP)
  • Length: 338  
  • Mass: 38231
• Sequence:

  MELWGRMLWALLSGPGRRGSTRGWAFSSWQPQPPLAGLSSAIELVSHWTGVFEKRGIPEARESSEYIVAHVLGAK
  TFQSLRPALWTQPLTSQQLQCIRELSSRRLQRMPVQYILGEWDFQGLSLRMVPPVFIPRPETEELVEWVLEEVAQ
  RSHAVGSPGSPLILEVGCGSGAISLSLLSQLPQSRVIAVDKREAAISLTHENAQRLRLQDRIWIIHLDMTSERSW
  THLPWGPMDLIVSNPPYVFHQDMEQLAPEIRSYEDPAALDGGEEGMDIITHILALAPRLLKDSGSIFLEVDPRHP
  ELVSSWLQSRPDLYLNLVAVRRDFCGRPRFLHIRRSGP

• Structural information:
  • Interpro: IPR002295  IPR002052  IPR004556  IPR040758  IPR019874   IPR029063  IPR007848  
  • Prosite: PS00092
  • STRING: ENSP00000404843
• Other Databases: GeneCards:  HEMK1  Malacards:  HEMK1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006306	DNA methylation	IEA	biological process
GO:0006479	protein methylation	IEA	biological process
GO:0008276	protein methyltransferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0003677	DNA binding	IEA	molecular function
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0008170	N-methyltransferase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0102559	protein-(glutamine-N5) methyltransferase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005739	mitochondrion	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881