• Gene id: 51386

Gene Summary

• Gene Symbol: EIF3L   Gene   UCSC   Ensembl
• Aliases: EIF3EIP, EIF3S11, EIF3S6IP, HSPC021, HSPC025, MSTP005
• Gene name: eukaryotic translation initiation factor 3 subunit L
• Alternate names: eukaryotic translation initiation factor 3 subunit L, eIEF associated protein HSPC021, eukaryotic translation initiation factor 3 subunit 6-interacting protein, eukaryotic translation initiation factor 3 subunit E-interacting protein,
• Gene location: 22q13.1 (141738320: 141750487)     Exons: 9     NC_000007.14

Protein Summary

• Protein general information: Q9Y262  
  • Name: Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6 interacting protein) (Eukaryotic translation initiation factor 3 subunit E interacting protein)
  • Length: 564  
  • Mass: 66727
• Sequence:

  MSYPADDYESEAAYDPYAYPSDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFHKTVSDLIDQKVYELQ
  ASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAPQVGNDAVFLILYKELYYRHIYAKVSGGPSL
  EQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVH
  SVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELN
  KKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIAL
  TMYPMRIDESIHLQLREKYGDKMLRMQKGDPQVYEELFSYSCPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDE
  VQQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDK
  DMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKMGQRP

• Structural information:
  • Protein Domains: (331..53-)
    (/note="PCI-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01185"-)
  • Interpro: IPR019382  IPR000717  IPR011990  
  • Prosite: PS50250
  • PDB: 3J8B 3J8C 6FEC
  • PDBsum: 3J8B 3J8C 6FEC
  • DIP: 31172
  • STRING: ENSP00000485663
• Other Databases: GeneCards:  EIF3L  Malacards:  EIF3L

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005852	eukaryotic translation initiation factor 3 complex	IBA	cellular component
GO:0006413	translational initiation	IBA	biological process
GO:0075525	viral translational termination-reinitiation	IDA	biological process
GO:0003743	translation initiation factor activity	IDA	contributes to
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0006413	translational initiation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005730	nucleolus	IEA	cellular component
GO:0005654	nucleoplasm	IEA	cellular component
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006413	translational initiation	IEA	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0001650	fibrillar center	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0033290	eukaryotic 48S preinitiation complex	IEA	cellular component
GO:0002183	cytoplasmic translational initiation	IEA	biological process
GO:0016282	eukaryotic 43S preinitiation complex	IEA	cellular component
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0001732	formation of cytoplasmic translation initiation complex	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0003743	translation initiation factor activity	IDA	contributes to
GO:0006413	translational initiation	IDA	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0006413	translational initiation	IC	biological process
GO:0006413	translational initiation	IC	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0016020	membrane	HDA	cellular component
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq