Gene id |
51377 |
Gene Summary Protein Summary Gene ontology Diseases PubMed |
Gene Summary
|
Gene Symbol |
UCHL5 Gene UCSC Ensembl |
Aliases |
CGI-70, INO80R, UCH-L5, UCH37 |
Gene name |
ubiquitin C-terminal hydrolase L5 |
Alternate names |
ubiquitin carboxyl-terminal hydrolase isozyme L5, INO80 complex subunit R, ubiquitin C-terminal hydrolase UCH37, ubiquitin carboxyl-terminal esterase L5, ubiquitin carboxyl-terminal hydrolase L5, ubiquitin thioesterase L5, |
Gene location |
1q31.2 (193060139: 193012253) Exons: 17 NC_000001.11
|
Protein Summary
|
Protein general information
| Q9Y5K5
Name: Ubiquitin carboxyl terminal hydrolase isozyme L5 (UCH L5) (EC 3.4.19.12) (Ubiquitin C terminal hydrolase UCH37) (Ubiquitin thioesterase L5)
Length: 329 Mass: 37607
|
Sequence |
MTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLD TIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFE FDTKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVS DRKMIYEQKIAELQRQLAEEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELL KTLAEHQQLIPLVEKAKEKQNAKKAQETK
|
Structural information |
|
Other Databases |
GeneCards: UCHL5 Malacards: UCHL5 |
|
GO accession | Term name | Evidence code | Go category |
---|
GO:0004843 |
thiol-dependent ubiquitin -specific protease activi ty
|
IBA |
molecular function |
GO:0005737 |
cytoplasm
|
IBA |
cellular component |
GO:0016579 |
protein deubiquitination
|
IBA |
biological process |
GO:0005829 |
cytosol
|
IDA |
cellular component |
GO:0004843 |
thiol-dependent ubiquitin -specific protease activi ty
|
IDA |
molecular function |
GO:0070628 |
proteasome binding
|
IDA |
molecular function |
GO:0070628 |
proteasome binding
|
IDA |
molecular function |
GO:0031011 |
Ino80 complex
|
IDA |
cellular component |
GO:0031011 |
Ino80 complex
|
IDA |
colocalizes with |
GO:0016579 |
protein deubiquitination
|
IDA |
biological process |
GO:0005634 |
nucleus
|
IDA |
cellular component |
GO:0004866 |
endopeptidase inhibitor a ctivity
|
IMP |
molecular function |
GO:0061136 |
regulation of proteasomal protein catabolic proces s
|
IMP |
biological process |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0004843 |
thiol-dependent ubiquitin -specific protease activi ty
|
IEA |
molecular function |
GO:0006511 |
ubiquitin-dependent prote in catabolic process
|
IEA |
biological process |
GO:0016579 |
protein deubiquitination
|
IEA |
biological process |
GO:0031011 |
Ino80 complex
|
IEA |
cellular component |
GO:0070628 |
proteasome binding
|
IEA |
molecular function |
GO:0016787 |
hydrolase activity
|
IEA |
molecular function |
GO:0008233 |
peptidase activity
|
IEA |
molecular function |
GO:0006508 |
proteolysis
|
IEA |
biological process |
GO:0006281 |
DNA repair
|
IEA |
biological process |
GO:0006974 |
cellular response to DNA damage stimulus
|
IEA |
biological process |
GO:0008234 |
cysteine-type peptidase a ctivity
|
IEA |
molecular function |
GO:0006310 |
DNA recombination
|
IEA |
biological process |
GO:0005634 |
nucleus
|
IEA |
cellular component |
GO:0005737 |
cytoplasm
|
IEA |
cellular component |
GO:0000502 |
proteasome complex
|
IEA |
cellular component |
GO:0036459 |
thiol-dependent ubiquitin yl hydrolase activity
|
IEA |
molecular function |
GO:0004843 |
thiol-dependent ubiquitin -specific protease activi ty
|
IMP |
molecular function |
GO:0016579 |
protein deubiquitination
|
IMP |
biological process |
GO:0045880 |
positive regulation of sm oothened signaling pathwa y
|
IMP |
biological process |
GO:0016579 |
protein deubiquitination
|
TAS |
biological process |
GO:0005654 |
nucleoplasm
|
TAS |
cellular component |
GO:0005829 |
cytosol
|
TAS |
cellular component |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005737 |
cytoplasm
|
IEA |
cellular component |
GO:0005634 |
nucleus
|
IEA |
cellular component |
GO:0005739 |
mitochondrion
|
IDA |
cellular component |
GO:0005654 |
nucleoplasm
|
IDA |
cellular component |
GO:0010951 |
negative regulation of en dopeptidase activity
|
IEA |
biological process |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0032435 |
negative regulation of pr oteasomal ubiquitin-depen dent protein catabolic pr ocess
|
IMP |
biological process |
GO:0003723 |
RNA binding
|
HDA |
molecular function |
|
|
Associated diseases |
References |
Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
21674046 |
Aberrant C pGs in Low Motility Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
|