• Gene id: 51329

Gene Summary

• Gene Symbol: ARL6IP4   Gene   UCSC   Ensembl
• Aliases: SFRS20, SR-25, SRp25, SRrp37
• Gene name: ADP ribosylation factor like GTPase 6 interacting protein 4
• Alternate names: ADP-ribosylation factor-like protein 6-interacting protein 4, ADP-ribosylation factor GTPase 6 interacting protein 4, ADP-ribosylation factor-like 6 interacting protein 4, ADP-ribosylation-like factor 6 interacting protein 4, ARL-6-interacting protein 4, HSP-9,
• Gene location: 12q24.31 (122980059: 122982912)     Exons: 6     NC_000012.12
• OMIM: 607668

Protein Summary

• Protein general information: Q66PJ3  
  • Name: ADP ribosylation factor like protein 6 interacting protein 4 (ARL 6 interacting protein 4) (Aip 4) (HSP 975) (HSVI binding protein) (SR 15) (SRp25) (SR 25) (Splicing factor SRrp37)
  • Length: 421  
  • Mass: 44915
  • Tissue specificity: Isoforms 3 and 7 were identified in brain, pancreas, prostate, and testis, but little or no message could be detected in other tissues. {ECO
• Sequence:

  MPRCTYQLEQNPGFLPDGPGVHARAHCQDLSGPYGHEFATSESLGGRVGKTRAPQSGARSRMERAGPAGEEGGAR
  EGRLLPRAPGAWVLRACAERAALEVGAASADTGVRGCGARGPAPLLASAGGGRARDGTWGVRTKGSGAALPSRPA
  SRAAPRPEASSPPLPLEKARGGLSGPQGGRARGAMAHVGSRKRSRSRSRSRGRGSEKRKKKSRKDTSRNCSASTS
  QGRKASTAPGAEASPSPCITERSKQKARRRTRSSSSSSSSSSSSSSSSSSSSSSSSSDGRKKRGKYKDKRRKKKK
  KRKKLKKKGKEKAEAQQVEALPGPSLDQWHRSAGEEEDGPVLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPE
  TGRTRLIKGDGEVLEEIVTKERHREINKQATRGDCLAFQMRAGLLP

• Structural information:
  • Interpro: IPR019532  
  • STRING: ENSP00000313422
• Other Databases: GeneCards:  ARL6IP4  Malacards:  ARL6IP4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008380	RNA splicing	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0006397	mRNA processing	IEA	biological process
GO:0005634	nucleus	TAS	cellular component
GO:0008380	RNA splicing	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005730	nucleolus	IEA	cellular component
GO:0016607	nuclear speck	IEA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray