• Gene id: 51228

Gene Summary

• Gene Symbol: GLTP   Gene   UCSC   Ensembl
• Gene name: glycolipid transfer protein
• Alternate names: glycolipid transfer protein, truncated glycolipid transfer protein,
• Gene location: 12q24.11 (109880540: 109850944)     Exons: 6     NC_000012.12
• Gene summary(Entrez): The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [provided by RefSeq, Jul 2008]
• OMIM: 608949

Protein Summary

• Protein general information: Q9NZD2  
  • Name: Glycolipid transfer protein (GLTP)
  • Length: 209  
  • Mass: 23850
  • Tissue specificity: Detected in fibroblasts (at protein level). Detected in fibroblasts and in various cancer cell lines. {ECO
• Sequence:

  MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTPIKADISGNITKIKAVYDTNPAKFRTLQNILE
  VEKEMYGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQA
  ALYAAPYKSDFLKALSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAELNYKV

• Structural information:
  • Interpro: IPR036497  IPR014830  
  • PDB: 1SWX 1SX6 2EUK 2EUM 2EVD 2EVL 2EVS 2EVT 3RIC 3RWV 3RZN 3S0I 3S0K 4GH0 4GHP 4GHS 4GIX 4GJQ 4GVT 4GXD 4GXG 4H2Z
  • PDBsum: 1SWX 1SX6 2EUK 2EUM 2EVD 2EVL 2EVS 2EVT 3RIC 3RWV 3RZN 3S0I 3S0K 4GH0 4GHP 4GHS 4GIX 4GJQ 4GVT 4GXD 4GXG 4H2Z
  • DIP: 59418
  • STRING: ENSP00000315263
• Other Databases: GeneCards:  GLTP  Malacards:  GLTP

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008289	lipid binding	IDA	molecular function
GO:0051861	glycolipid binding	IDA	molecular function
GO:0051861	glycolipid binding	IDA	molecular function
GO:1902388	ceramide 1-phosphate transfer activity	IBA	molecular function
GO:0035627	ceramide transport	IBA	biological process
GO:0016020	membrane	IBA	cellular component
GO:1902387	ceramide 1-phosphate binding	IBA	molecular function
GO:0120009	intermembrane lipid transfer	IBA	biological process
GO:0008289	lipid binding	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0120009	intermembrane lipid transfer	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0120013	lipid transfer activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0006869	lipid transport	IEA	biological process
GO:0017089	glycolipid transfer activity	TAS	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0006687	glycosphingolipid metabolic process	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0120013	lipid transfer activity	IDA	molecular function
GO:0005829	cytosol	IDA	cellular component
GO:0120009	intermembrane lipid transfer	IDA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:1902389	ceramide 1-phosphate transport	IEA	biological process
GO:0046836	glycolipid transport	IEA	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray