• Gene id: 51110

Gene Summary

• Gene Symbol: LACTB2   Gene   UCSC   Ensembl
• Aliases: CGI-83
• Gene name: lactamase beta 2
• Alternate names: endoribonuclease LACTB2, beta-lactamase-like protein 2, testicular secretory protein Li 23,
• Gene location: 8q13.3 (5282271: 5386339)     Exons: 20     NC_000017.11

Protein Summary

• Protein general information: Q53H82  
  • Name: Endoribonuclease LACTB2 (EC 3.1.27. ) (Beta lactamase like protein 2)
  • Length: 288  
  • Mass: 32806
• Sequence:

  MAAVLQRVERLSNRVVRVLGCNPGPMTLQGTNTYLVGTGPRRILIDTGEPAIPEYISCLKQALTEFNTAIQEIVV
  THWHRDHSGGIGDICKSINNDTTYCIKKLPRNPQREEIIGNGEQQYVYLKDGDVIKTEGATLRVLYTPGHTDDHM
  ALLLEEENAIFSGDCILGEGTTVFEDLYDYMNSLKELLKIKADIIYPGHGPVIHNAEAKIQQYISHRNIREQQIL
  TLFRENFEKSFTVMELVKIIYKNTPENLHEMAKHNLLLHLKKLEKEGKIFSNTDPDKKWKAHL

• Structural information:
  • Interpro: IPR041516  IPR001279  IPR036866  IPR036388  
  • PDB: 4AD9
  • PDBsum: 4AD9
  • STRING: ENSP00000276590
• Other Databases: GeneCards:  LACTB2  Malacards:  LACTB2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004521	endoribonuclease activity	IBA	molecular function
GO:0005759	mitochondrial matrix	IBA	cellular component
GO:0003727	single-stranded RNA binding	IBA	molecular function
GO:0004521	endoribonuclease activity	IDA	molecular function
GO:0008270	zinc ion binding	IDA	molecular function
GO:0003727	single-stranded RNA binding	IDA	molecular function
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IDA	biological process
GO:0005759	mitochondrial matrix	IDA	cellular component
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0004519	endonuclease activity	IEA	molecular function
GO:0004518	nuclease activity	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005759	mitochondrial matrix	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R