• Gene id: 51071

Gene Summary

• Gene Symbol: DERA   Gene   UCSC   Ensembl
• Aliases: CGI-26, DEOC
• Gene name: deoxyribose-phosphate aldolase
• Alternate names: deoxyribose-phosphate aldolase, 2-deoxy-D-ribose 5-phosphate aldolase, 2-deoxyribose-5-phosphate aldolase homolog, deoxyriboaldolase, deoxyribose-phosphate aldolase (putative), phosphodeoxyriboaldolase, putative deoxyribose-phosphate aldolase,
• Gene location: 12p12.3 (15911331: 16037380)     Exons: 11     NC_000012.12

Protein Summary

• Protein general information: Q9Y315  
  • Name: Deoxyribose phosphate aldolase (DERA) (EC 4.1.2.4) (2 deoxy D ribose 5 phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase)
  • Length: 318  
  • Mass: 35231
  • Tissue specificity: Mainly expressed in liver, lung and colon. {ECO
• Sequence:

  MSAHNRGTELDLSWISKIQVNHPAVLRRAEQIQARRTVKKEWQAAWLLKAVTFIDLTTLSGDDTSSNIQRLCYKA
  KYPIREDLLKALNMHDKGITTAAVCVYPARVCDAVKALKAAGCNIPVASVAAGFPAGQTHLKTRLEEIRLAVEDG
  ATEIDVVINRSLVLTGQWEALYDEIRQFRKACGEAHLKTILATGELGTLTNVYKASMIAMMAGSDFIKTSTGKET
  VNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDSLAWLSLVKEELGDEWLKPELFRIGASTLLSDIERQ
  IYHHVTGRYAAYHDLPMS

• Structural information:
  • Interpro: IPR013785  IPR011343  IPR002915  
  • CDD: cd00959
  • STRING: ENSP00000416583
• Other Databases: GeneCards:  DERA  Malacards:  DERA

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016052	carbohydrate catabolic process	IBA	biological process
GO:0009264	deoxyribonucleotide catabolic process	IBA	biological process
GO:0004139	deoxyribose-phosphate aldolase activity	IBA	molecular function
GO:0016829	lyase activity	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0004139	deoxyribose-phosphate aldolase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0009264	deoxyribonucleotide catabolic process	IEA	biological process
GO:0016829	lyase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0004139	deoxyribose-phosphate aldolase activity	IEA	molecular function
GO:0004139	deoxyribose-phosphate aldolase activity	TAS	molecular function
GO:0043312	neutrophil degranulation	TAS	biological process
GO:1904813	ficolin-1-rich granule lumen	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006098	pentose-phosphate shunt	TAS	biological process
GO:0034774	secretory granule lumen	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0046386	deoxyribose phosphate catabolic process	IEA	biological process
GO:0046121	deoxyribonucleoside catabolic process	IDA	biological process
GO:0004139	deoxyribose-phosphate aldolase activity	IDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00030	Pentose phosphate pathway

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq