• Gene id: 50940

Gene Summary

• Gene Symbol: PDE11A   Gene   UCSC   Ensembl
• Aliases: PPNAD2
• Gene name: phosphodiesterase 11A
• Alternate names: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP cyclic nucleotide phosphodiesterase 11A,
• Gene location: 2q31.2 (178108338: 177623243)     Exons: 24     NC_000002.12
• Gene summary(Entrez): The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates a
• OMIM: 604961

Protein Summary

• Protein general information: Q9HCR9  
  • Name: Dual 3',5' cyclic AMP and GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A)
  • Length: 933  
  • Mass: 104752
  • Tissue specificity: Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in tes
• Sequence:

  MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSSLAHSTCRGGSSVGGG
  TGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLS
  SVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKI
  LIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP
  DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQL
  FAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCS
  ADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQII
  GVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI
  PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQL
  MFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGH
  NIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWE
  ISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT
  NRSKWEELHQKRLLASTASSSPASVMVAKEDRN

• Structural information:
  • Protein Domains: (217..37-)
    (/note="GAF-1)
    (402..55-)
    (/note="GAF-2)
    (588..91-)
    (/note="PDEase-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01192"-)
  • Interpro: IPR003018  IPR029016  IPR003607  IPR023088  IPR002073   IPR036971  IPR023174  
  • Prosite: PS00126 PS51845
  • CDD: cd00077
  • STRING: ENSP00000286063
• Other Databases: GeneCards:  PDE11A  Malacards:  PDE11A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IBA	molecular function
GO:0010754	negative regulation of cGMP-mediated signaling	IBA	biological process
GO:0043951	negative regulation of cAMP-mediated signaling	IBA	biological process
GO:0007165	signal transduction	IEA	biological process
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA	molecular function
GO:0008081	phosphoric diester hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0008152	metabolic process	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	TAS	molecular function
GO:0007165	signal transduction	TAS	biological process
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0030553	cGMP binding	IDA	molecular function
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IDA	molecular function
GO:0004112	cyclic-nucleotide phosphodiesterase activity	NAS	molecular function
GO:0005575	cellular_component	ND	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00230	Purine metabolism
hsa04934	Cushing syndrome
hsa05032	Morphine addiction

Diseases

Associated diseases	References
Cushing syndrome	KEGG:H01431
Bilateral macronodular adrenal hyperplasia	KEGG:H02049
Pigmented micronodular adrenocortical disease	KEGG:H00260
Cushing syndrome	KEGG:H01431
Bilateral macronodular adrenal hyperplasia	KEGG:H02049
Pigmented micronodular adrenocortical disease	KEGG:H00260
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray