• Gene id: 50939

Gene Summary

• Gene Symbol: IMPG2   Gene   UCSC   Ensembl
• Aliases: IPM200, RP56, SPACRCAN, VMD5
• Gene name: interphotoreceptor matrix proteoglycan 2
• Alternate names: interphotoreceptor matrix proteoglycan 2, IPM 200, interphotoreceptor matrix proteoglycan IPM 200, interphotoreceptor matrix proteoglycan of 200 kDa, sialoprotein associated with cones and rods proteoglycan,
• Gene location: 3q12.3 (101320574: 101222545)     Exons: 19     NC_000003.12
• Gene summary(Entrez): The protein encoded by this gene binds chondroitin sulfate and hyaluronan and is a proteoglycan. The encoded protein plays a role in the organization of the interphotoreceptor matrix and may promote the growth and maintenance of the light-sensitive photor
• OMIM: 607056

Protein Summary

• Protein general information: Q9BZV3  
  • Name: Interphotoreceptor matrix proteoglycan 2 (Interphotoreceptor matrix proteoglycan of 200 kDa) (IPM 200) (Sialoprotein associated with cones and rods proteoglycan) (Spacrcan)
  • Length: 1241  
  • Mass: 138621
  • Tissue specificity: Expressed in the retina (at protein level) (PubMed
• Sequence:

  MIMFPLFGKISLGILIFVLIEGDFPSLTAQTYLSIEEIQEPKSAVSFLLPEESTDLSLATKKKQPLDRRETERQW
  LIRRRRSILFPNGVKICPDESVAEAVANHVKYFKVRVCQEAVWEAFRTFWDRLPGREEYHYWMNLCEDGVTSIFE
  MGTNFSESVEHRSLIMKKLTYAKETVSSSELSSPVPVGDTSTLGDTTLSVPHPEVDAYEGASESSLERPEESISN
  EIENVIEEATKPAGEQIAEFSIHLLGKQYREELQDSSSFHHQHLEEEFISEVENAFTGLPGYKEIRVLEFRSPKE
  NDSGVDVYYAVTFNGEAISNTTWDLISLHSNKVENHGLVELDDKPTVVYTISNFRDYIAETLQQNFLLGNSSLNP
  DPDSLQLINVRGVLRHQTEDLVWNTQSSSLQATPSSILDNTFQAAWPSADESITSSIPPLDFSSGPPSATGRELW
  SESPLGDLVSTHKLAFPSKMGLSSSPEVLEVSSLTLHSVTPAVLQTGLPVASEERTSGSHLVEDGLANVEESEDF
  LSIDSLPSSSFTQPVPKETIPSMEDSDVSLTSSPYLTSSIPFGLDSLTSKVKDQLKVSPFLPDASMEKELIFDGG
  LGSGSGQKVDLITWPWSETSSEKSAEPLSKPWLEDDDSLLPAEIEDKKLVLVDKMDSTDQISKHSKYEHDDRSTH
  FPEEEPLSGPAVPIFADTAAESASLTLPKHISEVPGVDDYSVTKAPLILTSVAISASTDKSDQADAILREDMEQI
  TESSNYEWFDSEVSMVKPDMQTLWTILPESERVWTRTSSLEKLSRDILASTPQSADRLWLSVTQSTKLPPTTIST
  LLEDEVIMGVQDISLELDRIGTDYYQPEQVQEQNGKVGSYVEMSTSVHSTEMVSVAWPTEGGDDLSYTQTSGALV
  VFFSLRVTNMMFSEDLFNKNSLEYKALEQRFLELLVPYLQSNLTGFQNLEILNFRNGSIVVNSRMKFANSVPPNV
  NNAVYMILEDFCTTAYNTMNLAIDKYSLDVESGDEANPCKFQACNEFSECLVNPWSGEAKCRCFPGYLSVEERPC
  QSLCDLQPDFCLNDGKCDIMPGHGAICRCRVGENWWYRGKHCEEFVSEPVIIGITIASVVGLLVIFSAIIYFFIR
  TLQAHHDRSERESPFSGSSRQPDSLSSIENAVKYNPVYESHRAGCEKYEGPYPQHPFYSSASGDVIGGLSREEIR
  QMYESSELSREEIQERMRVLELYANDPEFAAFVREQQVEEV

• Structural information:
  • Protein Domains: (239..35-)
    (/note="SEA-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00188-)
    (897..101-)
    (/note="SEA-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00188-)
    (1010..105-)
    (/note="EGF-like-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU000-)
  • Interpro: IPR013032  IPR000742  IPR039861  IPR032975  IPR000082   IPR036364  
  • Prosite: PS01186 PS50026 PS50024
  • STRING: ENSP00000193391
• Other Databases: GeneCards:  IMPG2  Malacards:  IMPG2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005540	hyaluronic acid binding	IBA	molecular function
GO:0008201	heparin binding	IBA	molecular function
GO:0005201	extracellular matrix structural constituent	IEA	molecular function
GO:0007601	visual perception	IEA	biological process
GO:0005540	hyaluronic acid binding	IEA	molecular function
GO:0033165	interphotoreceptor matrix	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0008201	heparin binding	IEA	molecular function
GO:0043235	receptor complex	IDA	cellular component
GO:0008201	heparin binding	IEA	molecular function
GO:0005540	hyaluronic acid binding	IEA	molecular function
GO:0033165	interphotoreceptor matrix	IEA	cellular component
GO:0007601	visual perception	TAS	biological process
GO:0031012	extracellular matrix	TAS	cellular component
GO:0005201	extracellular matrix structural constituent	TAS	molecular function
GO:0005540	hyaluronic acid binding	TAS	molecular function

Diseases

Associated diseases	References
Retinitis pigmentosa	KEGG:H00527
Vitelliform macular dystrophy	KEGG:H00814
Retinitis pigmentosa	KEGG:H00527
Vitelliform macular dystrophy	KEGG:H00814
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)