• Gene id: 50865

Gene Summary

• Gene Symbol: HEBP1   Gene   UCSC   Ensembl
• Aliases: HBP, HEBP
• Gene name: heme binding protein 1
• Alternate names: heme-binding protein 1, p22HBP,
• Gene location: 12p13.1 (13000264: 12974869)     Exons: 4     NC_000012.12
• Gene summary(Entrez): The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor
• OMIM: 605826

Protein Summary

• Protein general information: Q9NRV9  
  • Name: Heme binding protein 1 (p22HBP)
  • Length: 189  
  • Mass: 21097
• Sequence:

  MLGMIKNSLFGSVETWPWQVLSKGDKEEVAYEERACEGGKFATVEVTDKPVDEALREAMPKVAKYAGGTNDKGIG
  MGMTVPISFAVFPNEDGSLQKKLKVWFRIPNQFQSDPPAPSDKSVKIEEREGITVYSMQFGGYAKEADYVAQATR
  LRAALEGTATYRGDIYFCTGYDPPMKPYGRRNEIWLLKT

• Structural information:
  • Interpro: IPR011256  IPR006917  
  • STRING: ENSP00000014930
• Other Databases: GeneCards:  HEBP1  Malacards:  HEBP1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0020037	heme binding	IBA	molecular function
GO:0020037	heme binding	ISS	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0007623	circadian rhythm	TAS	biological process
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881