• Gene id: 5066

Gene Summary

• Gene Symbol: PAM   Gene   UCSC   Ensembl
• Aliases: PAL, PHM
• Gene name: peptidylglycine alpha-amidating monooxygenase
• Alternate names: peptidyl-glycine alpha-amidating monooxygenase, pancreatic peptidylglycine alpha-amidating monooxygenase, peptidyl alpha-amidating enzyme, peptidyl-alpha-hydroxyglycine alpha-amidating lyase, peptidylamidoglycolate lyase, peptidylglycine 2-hydroxylase, peptidyl,
• Gene location: 5q21.1 (102754782: 103031104)     Exons: 29     NC_000005.10
• Gene summary(Entrez): This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PH
• OMIM: 170270

Protein Summary

• Protein general information: P19021  
  • Name: Peptidyl glycine alpha amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl alpha hydroxyglycine alpha amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)]
  • Length: 973  
  • Mass: 108332
• Sequence:

  MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSNECLGTTRPVVPIDSSDFALDIRMPGVTPKQSDTYF
  CMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLPKGVG
  FRVGGETGSKYFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYK
  NYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATH
  IGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHEHHKETEYKDKIPLLQ
  QPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESESDLVAEIANVVQKKDLGRSDAREGAEHERGN
  AILVRDRIHKFHRLVSTLRPPESRVFSLQQPPPGEGTWEPEHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNL
  VIFHRGDHVWDGNSFDSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALH
  QVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSG
  SSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREIKHSSFGRNVFAISYIPGLLFAVNGKPHF
  GDQEPVQGFVMNFSNGEIIDIFKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQ
  EIKEAEAVVETKMENKPTSSELQKMQEKQKLIKEPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEH
  KLETSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSESEEEYSAPLPALAPSSS

• Structural information:
  • Interpro: IPR011042  IPR014784  IPR020611  IPR014783  IPR000323   IPR036939  IPR024548  IPR001258  IPR013017  IPR000720  IPR008977  
  • Prosite: PS00084 PS00085 PS51125
  • STRING: ENSP00000306100
• Other Databases: GeneCards:  PAM  Malacards:  PAM

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005576	extracellular region	IBA	cellular component
GO:0004504	peptidylglycine monooxygenase activity	IBA	molecular function
GO:0062112	fatty acid primary amide biosynthetic process	ISS	biological process
GO:0005509	calcium ion binding	ISS	molecular function
GO:0005507	copper ion binding	ISS	molecular function
GO:0030667	secretory granule membrane	ISS	cellular component
GO:0004598	peptidylamidoglycolate lyase activity	ISS	molecular function
GO:0004497	monooxygenase activity	IEA	molecular function
GO:0005507	copper ion binding	IEA	molecular function
GO:0006518	peptide metabolic process	IEA	biological process
GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0031418	L-ascorbic acid binding	IEA	molecular function
GO:0016829	lyase activity	IEA	molecular function
GO:0004497	monooxygenase activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0008152	metabolic process	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0004504	peptidylglycine monooxygenase activity	IEA	molecular function
GO:0004598	peptidylamidoglycolate lyase activity	IEA	molecular function
GO:0001666	response to hypoxia	IEA	biological process
GO:0001676	long-chain fatty acid metabolic process	IEA	biological process
GO:0004504	peptidylglycine monooxygenase activity	IEA	molecular function
GO:0005507	copper ion binding	IEA	molecular function
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005615	extracellular space	IEA	cellular component
GO:0005802	trans-Golgi network	IEA	cellular component
GO:0006357	regulation of transcription by RNA polymerase II	IEA	biological process
GO:0006518	peptide metabolic process	IEA	biological process
GO:0007417	central nervous system development	IEA	biological process
GO:0007595	lactation	IEA	biological process
GO:0008270	zinc ion binding	IEA	molecular function
GO:0009268	response to pH	IEA	biological process
GO:0018032	protein amidation	IEA	biological process
GO:0019538	protein metabolic process	IEA	biological process
GO:0030141	secretory granule	IEA	cellular component
GO:0032355	response to estradiol	IEA	biological process
GO:0043005	neuron projection	IEA	cellular component
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0051384	response to glucocorticoid	IEA	biological process
GO:0060135	maternal process involved in female pregnancy	IEA	biological process
GO:0062112	fatty acid primary amide biosynthetic process	IEA	biological process
GO:0001519	peptide amidation	IEA	biological process
GO:0004598	peptidylamidoglycolate lyase activity	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0007507	heart development	IEA	biological process
GO:0009404	toxin metabolic process	IEA	biological process
GO:0009986	cell surface	IEA	cellular component
GO:0019901	protein kinase binding	IEA	molecular function
GO:0022602	ovulation cycle process	IEA	biological process
GO:0030667	secretory granule membrane	IEA	cellular component
GO:0032956	regulation of actin cytoskeleton organization	IEA	biological process
GO:0042476	odontogenesis	IEA	biological process
GO:0042493	response to drug	IEA	biological process
GO:0042802	identical protein binding	IEA	molecular function
GO:0043025	neuronal cell body	IEA	cellular component
GO:0043204	perikaryon	IEA	cellular component
GO:0046688	response to copper ion	IEA	biological process
GO:0050708	regulation of protein secretion	IEA	biological process
GO:0060173	limb development	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0030658	transport vesicle membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0008270	zinc ion binding	IDA	molecular function
GO:0004504	peptidylglycine monooxygenase activity	IDA	molecular function
GO:0004504	peptidylglycine monooxygenase activity	IDA	molecular function
GO:0001519	peptide amidation	IDA	biological process
GO:0004598	peptidylamidoglycolate lyase activity	IDA	molecular function
GO:0001519	peptide amidation	IDA	biological process
GO:0010043	response to zinc ion	IDA	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0016020	membrane	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
prostate adenocarcinoma	PMID:11221851
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray