• Gene id: 5063

Gene Summary

• Gene Symbol: PAK3   Gene   UCSC   Ensembl
• Aliases: ARA, MRX30, MRX47, OPHN3, PAK-3, PAK3beta, bPAK, beta-PAK
• Gene name: p21 (RAC1) activated kinase 3
• Alternate names: serine/threonine-protein kinase PAK 3, adriamycin resistance-associated, oligophrenin-3, p21 (CDKN1A)-activated kinase 3, p21 protein (Cdc42/Rac)-activated kinase 3,
• Gene location: Xq23 (110944240: 111227360)     Exons: 29     NC_000023.11
• Gene summary(Entrez): The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic s
• OMIM: 603814

Protein Summary

• Protein general information: O75914  
  • Name: Serine/threonine protein kinase PAK 3 (EC 2.7.11.1) (Beta PAK) (Oligophrenin 3) (p21 activated kinase 3) (PAK 3)
  • Length: 559  
  • Mass: 62310
  • Tissue specificity: Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. {ECO
• Sequence:

  MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSD
  FEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQ
  KYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESI
  ASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA
  LDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD
  EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT
  RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSA
  KELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR

• Structural information:
  • Protein Domains: (70..8-)
    (/note="CRIB-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00057-)
    (283..53-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR000095  IPR036936  IPR011009  IPR033923  IPR000719   IPR017441  IPR008271  IPR035063  
  • Prosite: PS50108 PS00107 PS50011 PS00108
  • CDD: cd01093 cd06656
  • PDB: 6FD3
  • PDBsum: 6FD3
  • STRING: ENSP00000353864
• Other Databases: GeneCards:  PAK3  Malacards:  PAK3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0050770	regulation of axonogenesis	IBA	biological process
GO:0031098	stress-activated protein kinase signaling cascade	IBA	biological process
GO:0023014	signal transduction by protein phosphorylation	IBA	biological process
GO:0032147	activation of protein kinase activity	IBA	biological process
GO:0007346	regulation of mitotic cell cycle	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0004674	protein serine/threonine kinase activity	IBA	molecular function
GO:0030833	regulation of actin filament polymerization	IDA	biological process
GO:0004708	MAP kinase kinase activity	IDA	molecular function
GO:0050808	synapse organization	TAS	biological process
GO:0016358	dendrite development	ISS	biological process
GO:0060997	dendritic spine morphogenesis	ISS	biological process
GO:0060997	dendritic spine morphogenesis	TAS	biological process
GO:0007409	axonogenesis	ISS	biological process
GO:0004672	protein kinase activity	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0017124	SH3 domain binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0008152	metabolic process	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0007275	multicellular organism development	IEA	biological process
GO:0016310	phosphorylation	IEA	biological process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	TAS	molecular function
GO:0004674	protein serine/threonine kinase activity	TAS	molecular function
GO:0004674	protein serine/threonine kinase activity	TAS	molecular function
GO:0004674	protein serine/threonine kinase activity	TAS	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0031295	T cell costimulation	TAS	biological process
GO:0048013	ephrin receptor signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:2000573	positive regulation of DNA biosynthetic process	IEA	biological process
GO:0051020	GTPase binding	IEA	molecular function
GO:0043525	positive regulation of neuron apoptotic process	IEA	biological process
GO:0032956	regulation of actin cytoskeleton organization	IEA	biological process
GO:0010763	positive regulation of fibroblast migration	IEA	biological process
GO:0006468	protein phosphorylation	IEA	biological process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0004672	protein kinase activity	IEA	molecular function
GO:0071407	cellular response to organic cyclic compound	IEA	biological process
GO:0060997	dendritic spine morphogenesis	IEA	biological process
GO:0014069	postsynaptic density	IEA	cellular component
GO:0007409	axonogenesis	IEA	biological process
GO:0004672	protein kinase activity	IEA	molecular function
GO:0061003	positive regulation of dendritic spine morphogenesis	IEA	biological process
GO:0010975	regulation of neuron projection development	IEA	biological process
GO:0005768	endosome	IEA	cellular component
GO:0098978	glutamatergic synapse	IEA	cellular component
GO:0060996	dendritic spine development	IEA	biological process
GO:0017048	Rho GTPase binding	IEA	molecular function
GO:0016358	dendrite development	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0000165	MAPK cascade	IEA	biological process
GO:0000187	activation of MAPK activity	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04014	Ras signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa05132	Salmonella infection
hsa04510	Focal adhesion
hsa05130	Pathogenic Escherichia coli infection
hsa04360	Axon guidance
hsa05170	Human immunodeficiency virus 1 infection
hsa04660	T cell receptor signaling pathway
hsa04012	ErbB signaling pathway
hsa05211	Renal cell carcinoma

Diseases

Associated diseases	References
X-linked mental retardation	KEGG:H00480
X-linked mental retardation	KEGG:H00480
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray